Articles tagged "Liver transplantation"

2018 American Transplant Congress
Ischemia-Free Liver Transplantation in Pigs: Ischemia Reperfusion Injury is Avoidable?
Z. Guo, X. He, Y. Tang, F. Ji, Z. Zhang, Q. Zhao, S. Huang, Z. Zhu, W. Ju, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: In organ transplantation, ischemia and reperfusion injury (IRI) is considered as an inevitable event and the major contributor of graft failure. Great efforts have…
2018 American Transplant Congress
Derivation and Prospective External Validation of Prediction Models for Acute Kidney Injury in Adult Liver Transplant Recipients
Q. Zhao,¹ Z. Guo,¹ M. Chen,¹ S. Ma,¹ J. Lin,⁴ C. Zhang,² M. Han,³ X. He.¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China; ²Department of Hepatobiliary Surgery, Guangdong General Hospital, Guangzhou, China; ³Organ Transplant Department, The Eastern Hospital of the First Affiliated Hospital of SYSU, Guangzhou, China; ⁴Department of Hepatobiliary Surgery, The Third People's Hospital of Shenzhen, Shenzhen, China.
BACKGROUND: Acute kidney injury (AKI) is common in patients after liver transplantation, and has a marked impact on the perioperative and long-term morbidity and mortality.…
2018 American Transplant Congress
The Effect of Donor-Recipient Gender Matches on Living Donor Liver Transplantation
J. Han, Y. You, H. Choi, B. Kwak, D. Kim.
Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea.
PurposeSome investigators reported that the donor-recipient gender mismatches influence on long-term graft survival after deceased donor liver transplantation. The aim of this study was to…
2018 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2a Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski,¹ H. Atkins,² M. Macarthur,¹ C. Anne Marie,² D. Grant,¹ C. Bredsen,² E. Renner,¹ L. Lilly,¹ N. Selzner,¹ O. Adeyi,¹ R. Smith,¹ S. Moshkelgosha,¹ A. Humar,¹ S. Juvet,¹ G. Levy.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
Background: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
2018 American Transplant Congress
mTOR Inhibition with Everolimus in De Novo Living Donor Liver Transplantation – 24-Months Results from the H2307 Pivotal Trial
L. Jeng,¹ S. Lee,¹ A. Soin,¹ S. Uemoto,¹ D. Maluf,¹ J. Emond,¹ M. Meier,² J. Kochuparampil,² C. Sips,² S. Kaneko,³ G. Levy.¹
¹H2307 Study Group, Taichung, Taiwan; ²Novartis Pharma AG, Basel, Switzerland; ³Novartis Pharma KK, Tokyo, Japan.
Purpose: Everolimus (EVR) with reduced-dose tacrolimus (rTAC) has been shown to be efficacious in preventing graft rejection and improving renal function in deceased-donor liver transplant…
2018 American Transplant Congress
Recipient HO-1 Deficiency Decreases Post-Transplant Graft HO-1 Expression and Exacerbates Liver Transplant Damage
S. Kageyama,¹ K. Nakamura,¹ T. Ito,¹ A. Aziz,¹ B. Ke,¹ R. Sossa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Many preclinical studies on protective functions of heme oxygenase-1 (HO-1; hsp32) in orthotopic liver transplantation (OLT) have encouraged application of HO-1 inducing regimens in clinical…
2018 American Transplant Congress
Direct-Acting Antiviral Therapy Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Hepatitis C
C. Chan,¹ E. Agudelo,² J. Haydek,³ M. Hoteit,⁴ M. Laurito,⁵ J. Norvell,³ T. Schiano,⁶ N. Terrault,² E. Verna,⁵ A. Yang,¹ J. Levitsky.¹
¹Northwestern University, Chicago, IL; ²UCSF, San Francisco, CA; ³Emory University, Atl, GA; ⁴University of Pennsylvania, Philadelphia, PA; ⁵Columbia University, NY, NY; ⁶Mount Sinai, NY, NY.
Background and Aims:Interferon (IFN) treatment of hepatitis C virus (HCV) infection after liver transplantation (LT) can result in severe immune-mediated graft dysfunction (IGD). The occurrence…
2018 American Transplant Congress
Medication Adherence: Does Where You Live Matter?
S. Wadhwani,¹ S. Taylor,¹ C. Brokamp,¹ W. Guo,¹ E. Shemesh,² J. Bucuvalas.¹
¹Cincinnati Children's Hospital Medical Center, Cincinnati; ²Mount Sinai School of Medicine, New York.
Background & Objectives: Medication non-adherence remains problematic in pediatric liver transplant (LT)[mdash]estimates suggest that up to 53% of adolescents are non-adherent. We leveraged data from…
2018 American Transplant Congress
Long-Term Medical, Financial, Psychosocial, and Overall Health-Related Quality of Life after Living Donation in Liver Transplantation
J. Emamaullee,¹ L. Sher,¹ T-.L. Fong,² K. Dhanireddy,¹ S. Zielsdorf,¹ C. Romero,¹ N. Wade,¹ Y. Genyk.¹
¹Surgery, University of Southern California, Los Angeles, CA; ²Keck School of Medicine at the University of Southern California, Los Angeles, CA.
Background: The long-term impact of living donation (LD) in liver transplantation on health-related quality of life (HRQOL) has not been well characterized. This study was…
2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
H. Zhou,¹ Z. Rao,¹ Y. Xia,¹ R. Liu,¹ S. Zhou,¹ X. Wang,¹ Y. Zhai,¹ L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…