Articles tagged "Liver transplantation"

2018 American Transplant Congress
Serelaxin-Notch1 Signaling Promotes Macrophage M2 Differentiation and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation: From Mouse-to-Human
S. Kageyama,¹ K. Nakamura,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Background/Aim: We have documented crucial role of macrophage Notch1 signaling in a mouse warm hepatic ischemia-reperfusion injury (IRI) model. However, its clinical relevance or therapeutic…
2018 American Transplant Congress
Examples of the Observer Effect in Transplantation- Unintended Consequences of Regulation and Selected Outcome Metrics
A. Rana, M. Kueht, N. Galvan, R. Cotton, C. O'Mahony, J. Goss.
Abdominal Transplantation, Baylor College of Medicine, Houston, TX.
Introduction: The influence of an observer on the phenomena being observed is designated as the observer effect. It is our aim to demonstrate that an…
2018 American Transplant Congress
Effect of HLA Antibodies on Graft Survival in Adult Live Donor Liver Transplantation
M. Simpson,¹ M. Akoad,¹ F. Gordon,¹ Y-.L. Cheah,¹ C. Simon,¹ J. Pomposelli,² E. Pomfret.²
¹Transplantation, Lahey Hospital & Medical Center, Burlington, MA; ²Transplantation, University of Colorado Medical Center, Aurora, CO.
The relevance of HLA antibodies in liver transplantation is currently being re-evaluated. While hyperacute rejections are not an issue, antibody effects on long-term outcomes are…
2018 American Transplant Congress
Liver Retransplantation and Renal Failure: The Benefit of Simultaneous Kidney Transplant
J. Berumen,¹ V. Irine,² S. Mita,² S. Gabriel,¹ M. Kristin.¹
¹Department of Surgery, University of California San Diego, San Diego, CA; ²Department of Medicine, University of California San Diego, San Diego, CA.
Liver retransplantation has poor survival compared to primary liver transplant. Renal failure is a proven negative risk factor for survival with retransplant. Our aim was…
2018 American Transplant Congress
Measuring and Monitoring Equity in Access to Deceased Donor Liver Transplants
D. Stewart, A. Robinson, A. Harper, D. Klassen.
UNOS, Richmond.
Background: In 2016, the Organ Procurement and Transplantation Network (OPTN) developed a methodology to measure equity in deceased donor kidney allocation and has adapted it…
2018 American Transplant Congress
Regional Variation in the Outcomes of MELD-Na Based Liver Allocation
L. Chau,¹ D. Moonka,² K. Collins,¹ M. Rizzari,¹ A. Yoshida,¹ M. Abouljoud,¹ S. Nagai.¹
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Gastroenterology, Henry Ford Hospital, Detroit, MI.
Introduction: While there is known geographic discrepancy in waitlist and transplant outcomes in the MELD era, there is a paucity in understanding of these variations…
2018 American Transplant Congress
Kidney after Liver Transplant: A Matched Pair Analysis
M. Eerhart, J. Reyes, J. Danobeitia, L. Zitur, P. Chlebeck, L. Fernandez.
Surgery, University of Wisconsin, Madison, WI.
Background: Kidney after liver (KAL) transplantation is the best therapeutic option for patients with ESRD after liver transplantation (OLT). Current allocation policies create a safety…
2018 American Transplant Congress
Predicting Pediatric Liver Transplant Rejection with Peripheral Blood Leukocyte (PBL) Transcripts-Considerations and Design Limitations
M. Ningappa, C. Ashokkumar, Q. Sun, B. Higgs, K. Soltys, G. Bond, G. Mazariegos, R. Sindhi.
Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: Optimizing immunosuppression requires individualized rejection-risk assessment in children with liver transplantation (LTx). PBL transcripts are a desirable non-invasive solution. Purpose: To characterize PBL transcriptome…
2018 American Transplant Congress
Rituximab Induction to Prevent the Recurrence of PSC after Liver Transplantation-The Lessons Learned from ABO-Incompatible Living Donor Liver Transplantation-
Y. Yamada,¹ K. Hoshino,¹ M. Shinoda,¹ H. Obara,¹ S. Uemoto,³ T. Kaido,³ H. Okajima,³ T. Yagi,⁴ T. Yoshizumi,⁵ Y. Inomata,⁶ T. Hibi,⁶ K. Kubota,⁷ T. Suzuki,⁸ Y. Kitagawa,¹ H. Egawa,² T. Kuroda.¹
¹Surgery, Keio University School of Medicine, Tokyo, Japan; ²Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan; ³Division of Hepato-Biliary-Pancreatic Surgery and Transplant Surgery, Kyoto University, Kyoto, Japan; ⁴Hepato-Biliary and Pancreatic Surgery, Okayama University, Okayama, Japan; ⁵Department of Surgery, Kyushu University, Fukuoka, Japan; ⁶Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; ⁷Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan; ⁸Department of Pediatric Surgery, Fujita Health University School of Medicine, Aichi, Japan.
Background: Multiple studies have failed to reveal an effective method for preventing the recurrence of primary sclerosing cholangitis (PSC) after liver transplantation (LTx). A national…
2018 American Transplant Congress
Surgical Categorization Improve Outcomes and Organ Utilization in Liver Transplant
H. Bohorquez,^1,2 H. Sharma,¹ D. Bruce,¹ A. Cohen,^1,2 C. Carmody,^1,2 J. Seal,¹ E. Bugeaud,¹ D. Sonnier,¹ A. Mathur,¹ D. Marroquin,¹ M. Voltz,¹ D. Lucia,¹ G. Loss.^1,2
¹Multi-Organ Transplant Institute, Ochsner Helath System, New Orleans, LA; ²School of Medicine, University of Queensland, New Orleans, LA.
Background: Liver transplant (LT) varies greatly in technical complexity due to factors such as prior surgery, obesity, and portal vein thrombosis (PVT). This must be…