Articles tagged "Liver transplantation"

2022 American Transplant Congress
The Paradox of Lifestyle – Related Liver Disease: ASH and NASH
N. Kemmer¹, J. Buggs²
¹Transplant Hepatology, Tampa General Hospital, Tampa, FL, ²Transplant Surgery, Tampa General Hospital, Tampa, FL
*Purpose: In the last decade, the burden of lifestyle-related chronic disease has been on the rise and is considered a growing serious public health concern.…
2022 American Transplant Congress
Oxygen Saturation During Donor Warm Ischemia Time and Outcome of Donation After Circulatory Death (DCD) Liver Transplantation: A Review of 1207 Cases
S. Duehren, S. J. Cotler, H. Dahari, Z. Shi, C. Joyce, L. Fernandez, D. Lee
Loyola Univ Chicago, Maywood, IL
*Purpose: Donation after circulatory death (DCD) liver transplantation (LT) is associated with increased risk of graft failure due to the donor warm ischemia time (DWIT)…
2022 American Transplant Congress
Variation in Immunosuppressive Regimen in Children Receiving Liver Transplants: An Analysis of the UNOS Database
V. K. Raghu¹, J. E. Squires¹, C. Confair², E. Katz-Eisenberg², G. V. Mazariegos³, E. R. Perito⁴
¹Pediatrics, University of Pittsburgh, Pittsburgh, PA, ²Starzl Network for Excellence in Pediatric Transplantation, Pittsburgh, PA, ³UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ⁴Pediatrics, University of California San Francisco, San Francisco, CA
*Purpose: Optimizing immunosuppression (IS) was identified as a priority for pediatric liver transplant (LT) families and providers in the Starzl Network, a multi-center learning health…
2022 American Transplant Congress
Use of Monoclonal Antibodies for Treatment of Solid Organ Transplant Recipients with COVID-19: A Single Center Experience
S. Anjan¹, C. Vu², A. Vega², M. Maxam², J. Bini Viotti³, Y. Natori¹, J. Simkins¹, A. Khatri³, A. Mattiazzi¹, R. Vianna¹, J. Cienki², L. Lee², G. Guerra¹, L. Abbo²
¹Miami Transplant Institute, Miami, FL, ²Jackson Health System, Miami, FL, ³University of Miami Miller School of Medicine, Miami, FL
*Purpose: The risk of severe COVID-19 requiring hospitalization and death is higher in solid organ transplant recipients (SOTr). There remains limited data on the use…
2022 American Transplant Congress
Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx)
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro¹⁰, J. Pawlowska¹¹, P. Czubkowski¹¹, R. Mikolajczyk¹², U. Baumann¹³, C. Falk¹⁴
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Hannover; Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hannover; Hôpital Necker-Enfants Malades, Paris, France, ⁷Hannover; Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Children's Hospital, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Ospedali Riuniti di Bergamo, Bergamo, Italy, ¹¹Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹²German Center for Infection Research, TTU-IICH Hannover; MHH; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, ¹³Birmingham Children’s Hospital, UK; Division of Pediatric Gastroenterology and Hepatology, MHH, Hannover, Germany, ¹⁴Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed for a deep characterisation of the longitudinal immune dynamics during the first year after pLTx.*Methods: Absolute…
2022 American Transplant Congress
Impact of Sarcopenia Using L3 and Thigh Skeletal Muscle Index on Clinical Outcomes in Liver Transplantation Recipient
M. Lim, J. Kim
Department of Surgery, Samsung Medical Cener, Seoul, Korea, Republic of
*Purpose: Sarcopenia is defined as loss of muscle mass and function. It has been reported as a significant risk factor for outcome after Liver transplantation…
2022 American Transplant Congress
Acute Cellular Rejection in Liver Transplant Recipients Following Vaccination Against Covid-19
R. Sarwar¹, O. Adeyi², N. Lim¹
¹Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, ²Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
*Purpose: The coronavirus disease 2019 (COVID-19) global pandemic has seen the development of effective vaccines in record time. We report a series of five liver…
2022 American Transplant Congress
Evaluating the Performance and External Validity of Machine Learning-Based Prediction Models in Liver Transplantation: An International Study
T. Ivanics¹, D. So², M. P. Claasen³, D. Wallace⁴, M. Patel⁵, A. Gravely⁶, K. Walker⁷, T. Cowling⁷, L. Erdman⁸, G. Sapisochin³
¹University of Toronto - University Health Network, Toronto, ON, Canada, ²The Centre for Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ³Multi-organ transplant program, University Health Network, Toronto, ON, Canada, ⁴Department of Health Services Research and policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁵Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Multi-organ transplant program, University of Toronto - University Health Network, Toronto, ON, Canada, ⁷Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁸The Centre of Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: National liver transplant (LT) registries are curated in many countries. We compared data from three national registries and developed machine learning algorithm (MLA)-based models…
2022 American Transplant Congress
Analytical Evaluation and Comparison to STR of an Accurate and Sensitive Microchimerism Monitoring Tool for Liver Transplant Recipients
A. S. Kothari¹, C. Egidio¹, J. Miles², N. Gulbahce¹, S. Dholakia³, M. Grskovic⁴
¹Clinical Development, CareDx, South San Francisco, CA, ²Medical Affairs, CareDx, Brooklyn, NY, ³Medical Affairs, CareDx, South San Francisco, CA, ⁴CareDx, Brisbane, CA
*Purpose: Peripheral blood chimerism is associated with clinically relevant events post liver transplantation (LT). Accurate quantification of donor chimerism in LT recipients with ultra-sensitive chimerism…
2022 American Transplant Congress
Steatosis Following Liver Transplantation for Nonalcoholic Steatohepatitis is Associated with a Higher Rate of Cardiovascular Complications
W. Alhamoudi¹, S. Alqahtani², K. Bzeizi², A. Albenmousa², Y. Saleh², D. Broering², S. Alghamdi²
¹Medicine, King Saud University, Riyadh, Saudi Arabia, ²Liver Transplantation, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
*Purpose: Cirrhosis secondary to Nonalcoholic Steatohepatitis (NASH) is projected to become the leading indication for liver transplantation (LT) worldwide. Objectives: to evaluate the prevalence of…