ATC Abstracts

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Articles tagged "Liver preservation"

  • 2016 American Transplant Congress

    Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.

    H. Zhou,1,2 J. Zhu,1 S. Yue,1 R. Busuttil,1 J. Kupiec-weglinski,1 L. Lu,2 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

    Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…
  • 2016 American Transplant Congress

    Amino Acid (AA) Metabolism During Liver Allograft Preservation Comparing Subnormothermic Machine Perfusion (MP) Against Cold Storage (CS).

    B. Banan, R. Lopez, C. Hughes, G. Michalopoulos, P. Fontes.

    University of Pittsburgh, Pittsburgh.

    Introduction: Liver is the major site for nitrogen metabolism. Most hepatic transcriptional activity is related to protein-specific synthesis. Liver preservation has a direct impact in…
  • 2015 American Transplant Congress

    Normothermic Machine Perfusion (NMP) on Discarded Human Livers: The First Model in the US

    Q. Liu, A. Nassar, G. Iuppa, D. Urcuyo-Llanes, D. Sexton, T. Okamoto, T. Uso, A. Bennett, W. Baldwin, K. Abu-Elmagd, J. Fung, C. Miller, C. Quintini.

    Cleveland Clinic, Cleveland, OH.

    The benefit of NMP preservation has been reported in a number of animal studies. Herein we describe safety, feasibility and effectiveness of NMP on discarded…
  • 2015 American Transplant Congress

    "In-House" Controlled Oxygenated Rewarming After Initial Static Cold Storage: First Clinical Application in Marginal Donor Livers

    D. Hoyer,1 Z. Mathé,1 A. Gallinat,1 A. Canbay,2 J. Treckmann,1 U. Rauen,3 A. Paul,1 T. Minor.4

    1General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; 2Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany; 3Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 4Surgical Research Division, University Hospital Bonn, Bonn, Germany.

    IntroductionControlled oxygenated rewarming of cold stored livers by machine perfusion demonstrated a strong protective effect in preclinical studies. Here we report on the first clinical…
  • 2015 American Transplant Congress

    Hypothermic Machine Preservation Reduces Inflammatory, Hypoxic and Apoptotic Injuries in Human Liver Transplantation

    J. Guarrera, C. Bae, S. Henry.

    Center for Liver Disease and Transplantation, Columbia University Medical Center, New York, NY.

    Introduction: Hypothermic machine perfusion (HMP) is in its infancy in Liver Transplantation. We analyzed all molecular samples from our cumulative clinical experience at Columbia University.Methods:…
  • 2015 American Transplant Congress

    Somatostatin (Eumedica®) Infusion Allows Modulating Graft Flows and Gradients in Liver Transplantation. Results of a Randomized, Double Blind, Placebo Controlled Trial

    R. Troisi,1 A. Croo,1 E. Codarin,3 E. De Wolf,1 J. Van Limmen,4 G. Antoniali,3 B. Heyse,4 L. De Baerdemaeker,4 I. Colle,5 G. Tell,3 M. Sainz-Barriga.1,2

    1General Hepatobiliary Surgery Liver Transplantation Service, Ghent University Hospital Medical School, Ghent, Belgium; 2Digestive Surgery & Liver Transplantation, University of Tours, Tours, France; 3Medical & Biological Sciences, University of Udine, Udine, Italy; 4Anesthesiology, Ghent University Hospital Medical School, Ghent, Belgium; 5Gastroenterology, Ghent University Hospital Medical School, Ghent, Belgium.

    Background: Somatostatin (SST) infusion decrease portal pressure in acute variceal bleeding in cirrhotic patients. Despite liver transplantation (LTx), recipients with portal hypertension (PHT) display different…
  • 2015 American Transplant Congress

    Is Ex Vivo Liver Perfusion a Safe Alternative to Cold Static Storage for the Preservation of Standard Criteria Grafts?

    N. Goldaracena, V. Spetzler, M. Kaths, J. Echeverri, M. Selzner.

    Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.

    Objective: Subnormothermic ex vivo liver perfusion (SNEVLP) has recently attracted great interest in the field of organ preservation for marginal grafts. However, data is lacking…
  • 2015 American Transplant Congress

    Evaluation of the Effects of N-Acetylcysteine Treatment in Adult Liver Transplant Recipients

    E. Aldag, S. Farrell, R. Pedersen, A. Sahajpal, J. Clendenon, V. Gunabushanam, D. Kramer.

    Aurora St Luke's Medical Center, Milwaukee, WI.

    Background: N-acetylcysteine (NAC) has been used in post-orthotopic liver transplant (OLT) patients for the proposed mechanism of preventing tissue damage of the newly transplanted organ…
  • 2015 American Transplant Congress

    The Effect of Systemic Catecholamine Application On the Microcirculation in Liver Procurement

    M. Strempel,1 M. Kaths,1 H. Lang,1 G. Otto,1 V. Weyer,2 O. Kempski,3 A. Heimann,3 A. Schad,4 D. Foltys.1

    1Department of Transplantation and Hepatobiliopancreatic Surgery, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; 2Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; 3Institute of Neurosurgical Pathophysiology, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; 4Institute of Pathology, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany.

    Introduction: The most vulnerable part in liver transplantation remains the biliary system. There is evidence, that insufficient perfusion during multi-organ procurement plays a major role…
  • 2015 American Transplant Congress

    Diabetes Exacerbates Liver Ischemia and Reperfusion Injury By Activating the AGE-RAGE Pathway in Kupffer Cells

    S. Yue, J. Zhu, J. Rao, J. Kupiec-Weglinski, R. Busuttil, Y. Zhai.

    Surgery, UCLA, Los Angeles, CA.

    Although pre-transplant diabetes has been documented as a risk factor for mortality post-liver transplant, the underlying mechanism remains obscure. In a murine liver partial warm…
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