2016 American Transplant Congress
Extreme Hyperoxia During Pre-Implant Normothermic Liver Perfusion (PINLiP) Is Associated with Post-Reperfusion Syndrome and Vasoplegia.
Cambridge Transplant Unit, Addenbrookes Hospital, Cambridge, United Kingdom.
In response to the increasing number of DCD and marginal DBD donor livers, we started a programme of pre-implant normothermic perfusion (PINLiP) to enable functional…2016 American Transplant Congress
Outcomes for Liver Transplantation Using Organs from Donation After Cardiac Death Donors: A Single Center Experience.
Transplantation, University of Tennessee/Methodist University Transplant Institute, Memphis, TN.
Purpose: The use of donation after cardiac death (DCD) donors provides opportunity to help meet the demand for allografts needed for liver transplantation. However, concern…2016 American Transplant Congress
Alterations in Central Carbohydrate Metabolism in Porcine Liver Allografts Preserved with a Subnormothermic Machine Perfusion (SNMP) System.
University of Pittsburgh, Pittsburgh.
Introduction: Combination of reduced temperature and oxygenation via machine perfusion during liver allograft preservation has the potential to induce profound effects on hepatocyte bioenergetics and…2016 American Transplant Congress
Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.
Background & AimsAlthough mechanisms of liver immune activation against ischemia reperfusion injury (IRI) have been studied extensively, cellular bases have yet to be fully defined…2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with a Hemoglobin Based Oxygen Carrier (HBOC) Solution Reprograms Dynamic Inflammation Networks When Compared to Cold Storage (CS) in a Porcine Liver Allograft Model.
University of Pittsburgh, Pittsburgh.
Introduction: Inflammatory markers have been mostly studied by standard statistical analysis focused on single component variations. This study aimed to compare SNMP with CS regarding…2016 American Transplant Congress
Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.
Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…2016 American Transplant Congress
Amino Acid (AA) Metabolism During Liver Allograft Preservation Comparing Subnormothermic Machine Perfusion (MP) Against Cold Storage (CS).
University of Pittsburgh, Pittsburgh.
Introduction: Liver is the major site for nitrogen metabolism. Most hepatic transcriptional activity is related to protein-specific synthesis. Liver preservation has a direct impact in…2016 American Transplant Congress
Metabolic Recovery and Ex Vivo Simulation of Early Liver Reperfusion.
Purpose. An urgent need for more liver grafts for transplantation has prompted the use of more suboptimal organs. Particularly in these more marginal livers adequate…2016 American Transplant Congress
Lipid Metabolism and Preservation of Discarded Steatotic Human Livers Using 24 Hours Ex-Vivo Normothermic Machine Perfusion.
Cleveland Clinic, Cleveland, OH.
One primary reason to discard donor livers after procurement is severe steatosis. The impact of normothermic machine perfusion (NMP) on lipid metabolism and preservation of…2016 American Transplant Congress
Normothermic Ex Vivo Liver Perfusion (NEVLP) Using Steen Solution as Preservation Technique for Liver Transplantation-First Clinical Results.
Surgery, Toronto General Hospital, Toronto, Canada.
The European trial investigating NEVLP as preservation technique for liver transplantation uses Gelafusine, a non-FDA approved bovine derived gelatin-based perfusion solution. In contrast, we report…
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