2017 American Transplant Congress
36 Hours of Ex-Vivo Warm Cellular Perfusion of Swine Liver Using the Organ Care System (OCS™) Liver with Excellent Functional, Metabolic and Histological Outcomes.
Cold storage preservation results in ischemia/reperfusion injury to the donor liver, it lacks any resuscitative or assessment capabilities. The OCS™ Liver maintains livers in a…2017 American Transplant Congress
Improved Outcomes After Liver Transplantation from Controlled DCD Donors with Normothermic Regional Perfusion.
Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
Background: Normothermic regional perfusion (NRP) is currently explored as a method to recover organs from Maastricht category I-III Donors after circulatory death (DCD). This study…2017 American Transplant Congress
Early Results of the UK REVIVE Trial for Ex-Vivo Liver Warm Blood Perfusion of DCD and DBD Livers Using the Portable Organ Care System (OCS™) Liver Technology.
Hepatobiliary and Transplant Surgery, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Purpose:TheOCS Liver REVIVE Trial is a single-arm prospective trial to evaluate the safety and performance of OCS™ Liver system to preserve and assess DCD and…2017 American Transplant Congress
GSK3β and VDAC in Endoplasmic Reticulum Stress and Apoptosis Modulation During Orthotropic Liver Transplantation.
Ischemia reperfusion injury(IRI) is a major cause of graft non-function following liver transplantation (LT). Mitochondrial dysfunction plays a central role in preventing liver IRI), associated…2017 American Transplant Congress
Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.
One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…2017 American Transplant Congress
The Use of an Haemoglobin Based Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion.
Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts in an environment that mimics physiological conditions and therefore enables…2017 American Transplant Congress
Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.
Recently we provided evidence for a possible protective role of proteasome inhibition during liver graft preservation. Although, several reported data confirmed that the proteolytic activity…2017 American Transplant Congress
Prolonged Liver Ischemia Triggers Necrotic Depletion of TIM4+ Kupffer Cells to Facilitate Tissue Inflammatory Immune Activation in Liver Ischemia-Reperfusion Injury.
Although mechanisms of immune activation against liver ischemia-reperfusion injury (IRI) have been studied extensively, questions regarding liver resident Kupffer cells vs. infiltrating macrophages (iM[Oslash]s) remain…2017 American Transplant Congress
Objective Assessment of Graft Metabolism and Function During Ex Vivo Liver Perfusion.
During EVLP no objective perfusion parameters have been found to predict outcome after transplantation.Methods: Livers with 4grades of injury were perfused for 4 hours and…2016 American Transplant Congress
Serelaxin Decreases the Severity of Cold Ischemia-Reperfusion Injury After Liver Transplantation in Mice.
The Dumont-UCLA Transplantation Center, UCLA, Los Angeles, CA.
Background. Extended cold preservation contributes to ischemia-reperfusion injury (IRI), which impairs graft function and leads to poor clinical outcomes. Serelaxin (SER), a recombinant form of…
- « Previous Page
- 1
- …
- 5
- 6
- 7
- 8
- 9
- Next Page »