Articles tagged "Liver preservation"

2017 American Transplant Congress
Prolonged Liver Ischemia Triggers Necrotic Depletion of TIM4+ Kupffer Cells to Facilitate Tissue Inflammatory Immune Activation in Liver Ischemia-Reperfusion Injury.
H. Wang,¹ S. Yue,¹ M. Ni,¹ R. Busittil,¹ J. Kupiec-Weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA; ²Liver Surgery, The First affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu Province, China
Although mechanisms of immune activation against liver ischemia-reperfusion injury (IRI) have been studied extensively, questions regarding liver resident Kupffer cells vs. infiltrating macrophages (iM[Oslash]s) remain…
2017 American Transplant Congress
Objective Assessment of Graft Metabolism and Function During Ex Vivo Liver Perfusion.
J. Echeverri,¹ S. Cleland,² M. Kaths,¹ I. Linares,¹ R. Roizales,¹ N. Goldaracena,¹ D. Kollmann,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,³ D. Grant,¹ N. Selzner,⁴ M. Wasowicz,² M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ²Multi-Organ Transplant Program, Department of Anesthesia, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ³Multi-Organ Transplant Program, Department of Pathology, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ⁴Multi-Organ Transplant Program, Department of Medicine, University of Toronto - Toronto General Hospital, Toronto, ON, Canada
During EVLP no objective perfusion parameters have been found to predict outcome after transplantation.Methods: Livers with 4grades of injury were perfused for 4 hours and…
2017 American Transplant Congress
Preliminary Results of Clinical Normothermic Ex Vivo Liver Perfusion in a North American Setting.
M. Bral,¹ B. Gala-Lopez,¹ D. Bigam,¹ N. Kneteman,¹ A. Malcolm,¹ S. Livingstone,¹ A. Andres,¹ J. Emamaullee,¹ L. West,¹ P. Friend,² A. Shapiro.¹
¹Department of Surgery, University of Alberta, Edmonton, AB, Canada; ²Department of Surgery, Nuffield Department of Surgical Sciences, Oxford, United Kingdom; ³Oxford Institute of Biomedical Engineering, Oxford, United Kingdom; ⁴OrganOx, Oxford, United Kingdom
Outcomes of a first clinical normothermic machine perfusion (NMP) UK liver trial demonstrated feasibility and clear safety, with improved liver function when compared to standard…
2017 American Transplant Congress
Normothermic Regional Perfusion of Donors Following Circulatory Death Improves Outcomes in Liver Transplantation.
E. Mowlem,¹ L. Randle,² C. Fear,¹ K. Crick,¹ S. Messer,⁴ S. Large,⁴ A. Butler,³ C. Watson.³
¹Cambridge Transplant Unit, Addenbrookes Hospital, Cambridge, United Kingdom; ²OrganOx Ltd, Oxford, United Kingdom; ³Dept of Surgery, University of Cambridge, Cambridge, United Kingdom; ⁴Papworth Hospital, Cambridge, United Kingdom
Introduction: Donation after Circulatory Death (DCD) provides 23% of UK livers for transplantation, but such transplants are associated with more primary graft function and early…
2017 American Transplant Congress
A Proof of Concept for Liver Graft Modification Using Warm Ex Vivo Perfusion – “It Is Not Just About Rescuing Marginal Grafts”.
N. Goldaracena, J. Echeverri, N. Selzner, D. Grant, J. Feld, M. Selzner.
Toronto General Hospital, University of Toronto, Toronto, Canada
Background: The active metabolism during normothermic ex vivo liver perfusion (NEVLP) offers a new opportunity to use the preservation time for graft modification and repair…
2017 American Transplant Congress
First Report of Human Liver Transplantation After Normothermic Machine Perfusion (NMP) in the United States.
Q. Liu, B. Soliman, G. Iuppa, A. Nassar, A. Hassan, T. Diago Uso, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, J. Cywinski, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.
Cleveland Clinic, Cleveland
NMP is a novel preservation method for liver grafts. We transplanted 10 human livers after NMP to test the safety and feasibility of NMP on…
2017 American Transplant Congress
36 Hours of Ex-Vivo Warm Cellular Perfusion of Swine Liver Using the Organ Care System (OCS™) Liver with Excellent Functional, Metabolic and Histological Outcomes.
J. Magliocca,¹ J. Markmann,² M. Abouljoud,³ M. Ghobrial,⁴ A. Demetris.⁵
¹Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; ²Department of Surgery Division of Transplantation, Massachusetts General Hospital, Boston, MA; ³Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ⁴Surgery - General, Houston Methodist Hospital, Houston, TX; ⁵Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
Cold storage preservation results in ischemia/reperfusion injury to the donor liver, it lacks any resuscitative or assessment capabilities. The OCS™ Liver maintains livers in a…
2017 American Transplant Congress
Improved Outcomes After Liver Transplantation from Controlled DCD Donors with Normothermic Regional Perfusion.
G. Oniscu, F. Hunt, W. Herries, I. Currie, A. Sutherland, C. Beattie, E. Thomson.
Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
Background: Normothermic regional perfusion (NRP) is currently explored as a method to recover organs from Maastricht category I-III Donors after circulatory death (DCD). This study…
2017 American Transplant Congress
Early Results of the UK REVIVE Trial for Ex-Vivo Liver Warm Blood Perfusion of DCD and DBD Livers Using the Portable Organ Care System (OCS™) Liver Technology.
D. Vijayanand, F. Zahreldeen, J. Kingston, S. Farid, T. Mdlongwa, A. Ramsden, S. Willis, C. Moriarty, M. Attia.
Hepatobiliary and Transplant Surgery, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Purpose:TheOCS Liver REVIVE Trial is a single-arm prospective trial to evaluate the safety and performance of OCS™ Liver system to preserve and assess DCD and…
2016 American Transplant Congress
Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.
S. Yue,¹ H. Zhou,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsAlthough mechanisms of liver immune activation against ischemia reperfusion injury (IRI) have been studied extensively, cellular bases have yet to be fully defined…