2018 American Transplant Congress
Gene Silencing with p53 si-RNA Downregulates Inflammatory Markers in the Liver: Potential Utilization during Normothermic Machine Preservation
Background: RNA interference (RNAi) is a process through which RNA induces the activation of endogenous cellular pathways of RNA degradation, resulting in selective and potent…2018 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with Human Hemoglobin(Hb)-Based Oxygen Carriers (HBOCs)perfusate Decreased Hepatocellular Reperfusion Injury of Donation after Cardiac Death (DCD) Donor in Pig Model
Subnormothermic machine perfusion (SNMP) alleviate hepatoceller injury during organ preservation. However more oxygen is required when perfusate SNMP. Some studies demonstrated that SNMP with hemoglobin-based…2018 American Transplant Congress
Human Atrial Natriuretic Peptide (hANP) in Cold Storage of Donation after Cardiac Death Livers: A New Tool for Protecting Vascular Endothelia?
Aim: Current critical shortage of donor organs has led to acceptance of donation after cardiac death (DCD) livers for transplantation. Human atrial natriuretic peptide (hANP)…2018 American Transplant Congress
Supercooling of Human Livers to Extend the Preservation Time for Transplantation
Introduction: Extending the maximum preservation time of donor organs could dramatically improve the outcome of organ transplantation. Static cold storage (SCS) at +5[deg]C is the…2018 American Transplant Congress
The Role of Ex Vivo Normothermic Preservation in Minimizing Postreperfusion Syndrome in Liver Transplantation
Transplant Surgery, Cleveland Clinic, Cleveland.
Background:Graft reperfusion holds a major challenge during liver transplantation. NMP may improve post-reperfusion hemodynamics, reduce vasopressor and blood product transfusion.Methods:15 patients with liver transplantation after…2018 American Transplant Congress
Assessment of Bile Production and Quality during Normothermic Ex Vivo Liver Perfusion to Predict Biliary Injury
Background. Liver transplantation (LT) with donation after circulatory death (DCD)-grafts is associated with higher risk for biliary strictures. We evaluated bile production and quality during…2017 American Transplant Congress
GSK3β and VDAC in Endoplasmic Reticulum Stress and Apoptosis Modulation During Orthotropic Liver Transplantation.
Ischemia reperfusion injury(IRI) is a major cause of graft non-function following liver transplantation (LT). Mitochondrial dysfunction plays a central role in preventing liver IRI), associated…2017 American Transplant Congress
Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.
One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…2017 American Transplant Congress
The Use of an Haemoglobin Based Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion.
Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts in an environment that mimics physiological conditions and therefore enables…2017 American Transplant Congress
Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.
Recently we provided evidence for a possible protective role of proteasome inhibition during liver graft preservation. Although, several reported data confirmed that the proteolytic activity…
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