Articles tagged "Liver preservation"

2018 American Transplant Congress
The Role of Ex Vivo Normothermic Preservation in Minimizing Postreperfusion Syndrome in Liver Transplantation
A. Hassan, J. Cywinski, Q. Liu, D. Pezzati, D. Yang, L. Liu, G. Iuppa, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.
Transplant Surgery, Cleveland Clinic, Cleveland.
Background:Graft reperfusion holds a major challenge during liver transplantation. NMP may improve post-reperfusion hemodynamics, reduce vasopressor and blood product transfusion.Methods:15 patients with liver transplantation after…
2018 American Transplant Congress
Assessment of Bile Production and Quality during Normothermic Ex Vivo Liver Perfusion to Predict Biliary Injury
D. Kollmann,¹ I. Linares,¹ S. Ganesh,¹ R. Rosales,¹ M. Hamar,¹ P. Urbanellis,¹ A. Wiebe,¹ P. Yip,² O. Adeyi,² M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, Canada; ²Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada.
Background. Liver transplantation (LT) with donation after circulatory death (DCD)-grafts is associated with higher risk for biliary strictures. We evaluated bile production and quality during…
2018 American Transplant Congress
A Cost Analysis on Normothermic Machine Perfusion at a Single Center
D. Pezzati, Q. Liu, H. Hassan, G. Iuppa, L. Hernandez, G. D'Amico, T. Diago Uso, B. Heghtsad, C. Miller, C. Quintini.
General Surgery, Cleveland Clinic, Cleveland, OH.
INTRODUCTION: Normothermic machine perfusion (NMP) for liver transplantation is a novel and promising technique.One of the concerns related to its usage is the high cost.The…
2018 American Transplant Congress
Normothermic Ex Vivo Liver Perfusion Prior to Liver Transplantation Can Prevent Platelet Aggregation and Platelet Induced Sinusoidal Cell Injury
D. Kollmann,¹ I. Linares,¹ S. Ganesh,¹ R. Rosales,¹ N. Tessandier,² E. Boilard,² M. Hamar,¹ P. Urbanellis,¹ P. Yip,³ O. Adeyi,³ M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant, UHN, Toronto, Canada; ²Centre Hospitalier de l'Université Laval (CHUL), Québec, Canada; ³Laboratory Medicine and Pathobiology, UHN, Toronto, Canada.
Background. Normothermic ex vivo liver perfusion (NEVLP) is a novel method for graft-preservation applied alternatively to static cold storage (SCS). We examined the impact of…
2018 American Transplant Congress
Improving DCD Livers Graft Function Using CD47 Blockade in the Setting of Normothermic Liver Perfusion
S. Garcia-Aroz,¹ M. Xu,¹ X. Wang,¹ J. Hollingshead,¹ A. Khan,¹ B. Banan,¹ L. Kang,² Z. Zhang,¹ G. Upadhya,¹ Y. Lin,¹ P. Manning,³ W. Chapman.¹
¹Surgery, Washington University, St. Louis; ²Pathology, Washington University, St. Louis; ³Arch Oncology, St. Louis.
Background: Towards the goal of utilizing more livers for transplantation, transplant centers are looking to increase the use of organs from marginal donors. Livers from…
2018 American Transplant Congress
The First Series of Ischemia-Free Liver Transplantation in Human
X. He,¹ Z. Guo,¹ S. Huang,¹ Q. Zhao,¹ Y. Tang,¹ Z. Zhang,¹ Z. Zhu,¹ W. Ju,¹ L. Yang,² G. Chen.¹
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: Ischemia and reperfusion injury (IRI) is known as an inevitable event leading to early and late graft failure. We have performed the first case…
2017 American Transplant Congress
Preliminary Results of Clinical Normothermic Ex Vivo Liver Perfusion in a North American Setting.
M. Bral,¹ B. Gala-Lopez,¹ D. Bigam,¹ N. Kneteman,¹ A. Malcolm,¹ S. Livingstone,¹ A. Andres,¹ J. Emamaullee,¹ L. West,¹ P. Friend,² A. Shapiro.¹
¹Department of Surgery, University of Alberta, Edmonton, AB, Canada; ²Department of Surgery, Nuffield Department of Surgical Sciences, Oxford, United Kingdom; ³Oxford Institute of Biomedical Engineering, Oxford, United Kingdom; ⁴OrganOx, Oxford, United Kingdom
Outcomes of a first clinical normothermic machine perfusion (NMP) UK liver trial demonstrated feasibility and clear safety, with improved liver function when compared to standard…
2017 American Transplant Congress
Normothermic Regional Perfusion of Donors Following Circulatory Death Improves Outcomes in Liver Transplantation.
E. Mowlem,¹ L. Randle,² C. Fear,¹ K. Crick,¹ S. Messer,⁴ S. Large,⁴ A. Butler,³ C. Watson.³
¹Cambridge Transplant Unit, Addenbrookes Hospital, Cambridge, United Kingdom; ²OrganOx Ltd, Oxford, United Kingdom; ³Dept of Surgery, University of Cambridge, Cambridge, United Kingdom; ⁴Papworth Hospital, Cambridge, United Kingdom
Introduction: Donation after Circulatory Death (DCD) provides 23% of UK livers for transplantation, but such transplants are associated with more primary graft function and early…
2017 American Transplant Congress
A Proof of Concept for Liver Graft Modification Using Warm Ex Vivo Perfusion – “It Is Not Just About Rescuing Marginal Grafts”.
N. Goldaracena, J. Echeverri, N. Selzner, D. Grant, J. Feld, M. Selzner.
Toronto General Hospital, University of Toronto, Toronto, Canada
Background: The active metabolism during normothermic ex vivo liver perfusion (NEVLP) offers a new opportunity to use the preservation time for graft modification and repair…
2017 American Transplant Congress
First Report of Human Liver Transplantation After Normothermic Machine Perfusion (NMP) in the United States.
Q. Liu, B. Soliman, G. Iuppa, A. Nassar, A. Hassan, T. Diago Uso, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, J. Cywinski, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.
Cleveland Clinic, Cleveland
NMP is a novel preservation method for liver grafts. We transplanted 10 human livers after NMP to test the safety and feasibility of NMP on…