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Articles tagged "Liver preservation"

  • 2020 American Transplant Congress

    Ex Vivo Pumping Through an OPO’s Eyes

    A. L. Friedman, E. Marquez

    LiveOnNY, New York, NY

    *Purpose: A single, large organ procurement organization (OPO) sought to document the use of extra-renal ex vivo pumping in the management of the deceased donor…
  • 2020 American Transplant Congress

    Ex-Vivo Perfusion with UW Cold Storage Solution Improves DCD Rat Liver Preservation

    R. Fyffe-Freil, N. Wickramaratne, J. Khoraki, H. Kang, C. Chmielewski, R. Li, M. J. Mangino

    Surgery, Virginia Commonwealth University, Richmond, VA

    *Purpose: The donor pool of livers can be expanded by the successful use of donor livers recovered under DCD conditions. It is assumed that perfusion…
  • 2020 American Transplant Congress

    Normothermic Machine Perfusion of Rat Liver: Comparing Two Perfusion Methods

    F. Zhou, M. Xu, O. Ahmed, G. A. Upadhya, Y. Lin, W. C. Chapman

    Surgery, Washington University in St. Louis, St. Louis, MO

    *Purpose: Isolated perfused rodent liver (IPRL) model has gained popularity in ex-vivo rat liver preservation and pharmacological intervention studies. Experimental conditions and system layouts vary…
  • 2020 American Transplant Congress

    DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions

    R. G. Bardallo1, R. G. Teixeira-Silva2, A. Panisello-Rosello3, E. Folch-Puy3, J. Rosello Catafau4, T. Carbonell5

    1Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain, 2Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, CSIC, Barcelona, Spain, 3Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain, 4Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, Spain, 5Cell Biology, Physiollogy and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain

    *Purpose: Preservation solutions (UW, HTK and IGL-1) are widely used in clinical liver transplantation. It is well known that the composition of the preservation solution…
  • 2020 American Transplant Congress

    TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury

    M. Ni1, J. Zhang1, R. Sosa2, S. Kageyama1, R. Busuttil1, R. Elaine2, J. Kupiec-Weglinski1, X. Wang3, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2Pathology, David Geffen School of Medicine-UCLA, Los Angeles, CA, 3Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…
  • 2019 American Transplant Congress

    Normothermic Regional Perfusion of Kidneys: A Single Non-Retrieval Centre Experience

    R. Pearson, C. Geddes, M. Clancy, J. Asher

    Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom

    *Purpose: With the aim of safely expanding the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional (NRP) perfusion…
  • 2019 American Transplant Congress

    Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function

    T. Goto, I. Linares, S. Ganesh, L. Mazilescu, P. Urbanellis, N. Selzner, M. Selzner

    Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada

    *Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…
  • 2019 American Transplant Congress

    Alpha-1 Antitrypsin Reduces Liver Ischemia Reperfusion Injury during Ex-Vivo Normothermic Machine Perfusion

    D. Detelich1, R. de Vries1, C. Carroll1, M. Stein2, K. Uygun1, H. Yeh1, J. Markmann1

    1Massachusetts General Hospital, Boston, MA, 2Kamada, Rehovot, Israel

    *Purpose: Normothermic machine perfusion is an emerging preservation method in liver transplantation with vast potential as a platform for ex-vivo graft reconditioning. Alpha-1 Antitrypsin (AAT)…
  • 2019 American Transplant Congress

    Multi-omic Analysis Of Hepatic Ischemia/reperfusion Injury Identifies Novel Targets To Mitigate Hepatocellular Damage

    S. Duarte1, V. Boominathan2, Z. Huo3, A. Kobayashi2, U. Kim2, Y. Lai2, A. Coito1, A. Zarrinpar2

    1Surgery, UCLA, Los Angeles, CA, 2Surgery, University of Florida, Gainesville, FL, 3Biostatistics, University of Florida, Gainesville, FL

    *Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major risk factor for acute rejection and early graft dysfunction in liver transplantation. The large and complex landscape…
  • 2019 American Transplant Congress

    ‘Back-to-Base’ Normothermic Clinical Liver Perfusion – Cold before NMP Does Not Compromise Protective Benefit

    K. Dajani, M. Bral, D. leon Izquierdo, D. Bigam, N. Kneteman, J. Shapiro

    University of Alberta Hospital, Edmonton, AB, Canada

    *Purpose: In previous clinical studies utilizing normothermic ex situ liver machine preservation, perfusion was initiated rapidly following organ procurement using a portable system transported to…
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