Articles tagged "Liver preservation"

2020 American Transplant Congress
Rouleaux Formation in Human Livers During Normothermic Machine Perfusion
M. Harris¹, S. Raigani², C. Albert³, M. Reschke³, C. Carroll², J. T. Langford¹, C. Edwards⁴, D. Mulligan⁴, D. Haakinson¹, K. Uygun², H. Yeh², G. Tietjen¹
¹Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, ²Division of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Yale School of Engineering and Applied Science, New Haven, CT, ⁴Surgery, Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT
*Purpose: We recently discovered that red blood cells form rouleaux plugs in human kidney vasculature during normothermic machine perfusion (NMP) and are associated with poor…
2020 American Transplant Congress
Bridging the Gap: Normothermic Perfusion of Discarded Livers Significantly Alleviates the Donor Shortage
S. Raigani, R. J. De Vries, C. Carroll, Y. Chen, D. C. Chang, K. Uygun, H. Yeh
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: European studies have shown that discarded liver grafts can be successfully transplanted if they meet viability criteria during normothermic machine perfusion (NMP). The potential…
2020 American Transplant Congress
Association of Perfusion Characteristics and Post-Transplant Liver Function in Ischemia-Free Liver Transplantation
Z. Zhang, Y. Tang, Q. Zhao, Z. Guo, X. He
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: It has been showed that normothermic machine perfusion (NMP), a novel preservation method, is able to assess and resuscitate liver grafts with risk factors.…
2020 American Transplant Congress
Ex Vivo Pumping Through an OPO’s Eyes
A. L. Friedman, E. Marquez
LiveOnNY, New York, NY
*Purpose: A single, large organ procurement organization (OPO) sought to document the use of extra-renal ex vivo pumping in the management of the deceased donor…
2020 American Transplant Congress
Ex-Vivo Perfusion with UW Cold Storage Solution Improves DCD Rat Liver Preservation
R. Fyffe-Freil, N. Wickramaratne, J. Khoraki, H. Kang, C. Chmielewski, R. Li, M. J. Mangino
Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: The donor pool of livers can be expanded by the successful use of donor livers recovered under DCD conditions. It is assumed that perfusion…
2019 American Transplant Congress
Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion
S. Raigani¹, N. Karimian², V. Huang², S. Geerts², S. Nagpal², K. Uygun¹, M. Yarmush¹, H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Center for Engineering in Medicine, Shriners Childrens Hospital, Boston, MA
*Purpose: Nearly 40-60% of discarded livers are due to steatosis because of poor recovery from ischemia-reperfusion injury and compromised post-transplant function. We evaluated steatotic (ST)…
2019 American Transplant Congress
Pharmacological Enhancement of Bile Duct Preservation and Function during Ex-Situ Normothermic Machine Perfusion
Y. L. Boteon, J. Attard, A. P. Boteon, L. Wallace, G. Reynolds, D. Mirza, H. Mergental, R. Bhogal, S. Afford
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
*Purpose: Whilst ex-situ normothermic machine perfusion (NMP) of the liver limits the ischaemic injury to the organ, benefits for biliary complications post-transplantation are not yet…
2019 American Transplant Congress
Combined Thoracic-Liver Transplants Using Normothermic Machine Perfusion for Liver Preservation: A Case Series
M. Rizzari, K. Crombez, S. Nagai, J. Stracke, A. Al-Kurd, K. Collins, A. Yoshida, M. Abouljoud
Henry Ford Transplant Institute, Detroit, MI
*Purpose: There is minimal data describing combined thoracic-liver transplants (tx) with normothermic machine perfusion (NMP) used for liver preservation as the thoracic tx is done.…
2019 American Transplant Congress
Normothermic Regional Perfusion of Kidneys: A Single Non-Retrieval Centre Experience
R. Pearson, C. Geddes, M. Clancy, J. Asher
Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom
*Purpose: With the aim of safely expanding the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional (NRP) perfusion…
2019 American Transplant Congress
Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function
T. Goto, I. Linares, S. Ganesh, L. Mazilescu, P. Urbanellis, N. Selzner, M. Selzner
Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…