Articles tagged "Liver preservation"

2022 American Transplant Congress
Organ Care System Use in Liver Transplantation Shifts Preservation-Reperfusion Injury in Time and Space
A. J. Demetris, M. A. Wood-Trageser, D. Lesniak, -. The PROTECT Investigators
Department of Transplant Pathology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Liver allograft ischemia-reperfusion injury (IRI) causes early allograft dysfunction (EAD). The TransMedics Organ Care System (OCS) PROTECT trial for liver transplantation (NCT02522871) revealed that…
2022 American Transplant Congress
Prolonged Preservation by Hypothermic Machine Perfusion Facilitates Logistics in Liver Transplantation: A European Observational Cohort Study
I. M. Brüggenwirth¹, M. Mueller², V. A. Lantinga¹, S. Camagni³, R. De Carlis⁴, L. De Carlis⁵, M. Colledan⁶, D. Dondossola⁷, M. Drefs⁸, J. Eden², D. Ghinolfi⁹, D. Koliogiannis¹⁰, G. Lurje¹¹, T. Manzia¹², D. Monbaliu¹³, P. Muisean¹⁴, D. Patrono¹⁵, J. Pratschke¹⁶, R. Romagnoli¹⁷, M. Rayar¹⁸, F. Roma¹⁴, A. Schlegel², P. Dutkowski², R. J. Porte¹, V. E. de Meijer¹
¹University Medical Center Groningen, Groningen, Netherlands, ²University Hospital Zurich, Zurich, Switzerland, ³ASST Papa Giovanni XXIII, Bergamo, Italy, ⁴ASST Grande Ospedale Metropolitano Niguarda, Niguarda, Italy, ⁵Niguarda Ca’ Granda Hospital, Niguarda, Italy, ⁶Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy, ⁷Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy, ⁸University of Munich, Munich, Germany, ⁹Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, ¹⁰Hospital of the University of Munich, Munich, Germany, ¹¹Charité Universitätsmedizin Berlin, Berlin, Germany, ¹²Tor Vergata University, Rome, Italy, ¹³KU Leuven University Hospitals Leuven, Leuven, Belgium, ¹⁴Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ¹⁵A. O. U. Città della Salute e della Scienza di Torino, Turin, Italy, ¹⁶Charite Universitatsmedizin Berlin, Berlin, Germany, ¹⁷AOU Città della Salute e della Scienza di Torino, Turin, Italy, ¹⁸CHU Pontchaillou, Rennes, France
*Purpose: A short period (1-2 hours) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver…
2022 American Transplant Congress
Ex Vivo End Ischemic Hypothermic Oxygenated Perfusion (hope) Versus Static Cold Storage Prior To Liver Transplantation – Preliminary Results Of The Bridge To Hope Pivotal Multicenter Randomized Controlled Clinical Trial On The Safety And Effectiveness Of The Vitasmart Liver Machine Perfusion System (clinicaltrials.gov: Nct05045794)
D. J. Reich¹, A. Schlegel², M. Rizzari³, D. Foley⁴, M. DeVera⁵, W. Chapman⁶, G. Roll⁷, A. Saharia⁸, C. Quintini⁹, S. Florman¹⁰, S. Merani¹¹, S. Mao¹², A. Pinna¹³, M. Akoad¹⁴, C. Kubal¹⁵, S. Alexopoulos¹⁶, H. Bohorquez¹⁷
¹Drexel University, Philadelphia, PA, ²Careggi U, Florence, Italy, ³Henry Ford, Detroit, MI, ⁴U Wisconsin, Madison, WI, ⁵Loma Linda, Loma Linda, CA, ⁶Washington U, Saint Louis, MO, ⁷UCSF, SF, CA, ⁸Methodist, Houston, TX, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Mount Sinai, NY, NY, ¹¹U Nebraska, Omaha, NE, ¹²Mayo, Jacksonville, FL, ¹³Cleveland Clinic, Weston, FL, ¹⁴Lahey, Burlington, MA, ¹⁵Indiana U, Indianapolis, IN, ¹⁶Vanderbilt, Nashville, TN, ¹⁷Ochsner, New Orleans, LA
*Purpose: Ex vivo end ischemic hypothermic oxygenated machine perfusion (HOPE) is a simple technique to improve liver transplant (LT) results and the donor shortage. HOPE…
2022 American Transplant Congress
Deceased Donor Organ Flush with Similar Volumes of HTK and UW at a Single U.S. Organ Procurement Organization: Adult and Pediatric Data
A. E. Mangus¹, C. Kubal², B. Ekser³, P. Mihaylov⁴, A. J. Lutz¹, J. Fridell⁵, R. Mangus⁶
¹Indiana University Purdue University of Indianapolis, Indianapolis, IN, ²Indiana University Hospital, Indianapolis, IN, ³Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, ⁴Indiana Univ School of Medicine, Indianapolis, IN, ⁵Indiana University School of Medicine, Indianapolis, IN, ⁶Indiana University, Indianapolis, IN
*Purpose: Histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solutions are the two primary solid-organ preservation solutions used in the United States (>95%), but flush volumes…
2022 American Transplant Congress
A Multicenter Randomized Controlled Trial To Compare The Efficacy Of Ex-vivo Machine Perfusion With Static Cold Storage In Human Liver Transplantation: The University Of Maryland Experience
J. Avruch¹, N. Goussous², S. Malik¹, M. Pinedo¹, R. Meier¹, C. Bhati¹, D. Maluf¹, R. Barth³, J. Alvarez-Casas¹
¹Transplant Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Transplant Surgery, University of California Davis Health, Davis, CA, ³University of Chicago, Chicago, IL
*Purpose: There is accumulating clinical evidence of the benefit of normothermic ex-vivo machine perfusion (NMP) compared with traditional static cold storage of liver allografts prior…
2022 American Transplant Congress
Characterization of Acute Kidney Injury in Fatty Liver Ischemia Reperfusion Injury
Z. P. Rokop, W. Zhang, N. Ghosh, A. Das, N. Biswas, C. Sen, C. Kubal
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
*Purpose: The association between hepatic ischemia reperfusion injury (hIRI) and acute kidney injury (AKI) has been well established. AKI is commonly observed following transplantation of…
2022 American Transplant Congress
HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels
C. OBrien¹, P. Hernandez¹, S. Concors², Z. Wang¹, G. Ge³, A. Kozikowski⁴, W. Hancock⁵, M. Levine²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Surgery, University of Pensylvania, Philadelphia, PA, ⁴College of Pharmacy, University of Illinois at Chicago, Chicago, IL, ⁵Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
2022 American Transplant Congress
Ultrasound Targeted Microbubble Cavitation During Ex Vivo Normothermic Machine Perfusion Reduces Peribiliary Vascular Plexus Thrombi and Graft Injury in a DCD Liver Transplant Model
Y. Nigmet¹, C. Hughes¹, X. Chen², A. Demetris³, D. Stolz⁴, J. Pacella², A. Humar⁵, F. Villanueva²
¹Transplant Surgery, University of Pittsburgh, Pittsburgh, PA, ²Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, PA, ³Transplant Pathology, University of Pittsburgh, Pittsburgh, PA, ⁴Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA, ⁵Thomas E Starzl Transplant Inst, Pittsburgh, PA
*Purpose: Thrombus formation in the peribiliary vascular plexus (PBP) is a proposed mechanism for ischemic cholangiopathy (IC) after liver transplantation from donors after circulatory death…
2021 American Transplant Congress
Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, J. Aziz¹, X. Li², J. W. Kupiec-Weglinski¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…
2021 American Transplant Congress
Cross-Circulation for Extracorporeal Liver Support in a Swine Model
W. K. Wu¹, A. Tumen¹, J. W. Stokes², R. Ukita², A. E. Hozain³, C. R. Flynn², M. J. Lee³, J. R. Talackine², N. L. Cardwell², J. A. Reimer³, M. Pinezich³, C. Benson², G. Vunjak-Novakovic³, S. P. Alexopoulos², M. Bacchetta²
¹co-first authors, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN, ³Columbia University Medical Center, New York, NY
*Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…

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