ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver preservation"

  • 2022 American Transplant Congress

    Ex Vivo End Ischemic Hypothermic Oxygenated Perfusion (hope) Versus Static Cold Storage Prior To Liver Transplantation – Preliminary Results Of The Bridge To Hope Pivotal Multicenter Randomized Controlled Clinical Trial On The Safety And Effectiveness Of The Vitasmart Liver Machine Perfusion System (clinicaltrials.gov: Nct05045794)

    D. J. Reich1, A. Schlegel2, M. Rizzari3, D. Foley4, M. DeVera5, W. Chapman6, G. Roll7, A. Saharia8, C. Quintini9, S. Florman10, S. Merani11, S. Mao12, A. Pinna13, M. Akoad14, C. Kubal15, S. Alexopoulos16, H. Bohorquez17

    1Drexel University, Philadelphia, PA, 2Careggi U, Florence, Italy, 3Henry Ford, Detroit, MI, 4U Wisconsin, Madison, WI, 5Loma Linda, Loma Linda, CA, 6Washington U, Saint Louis, MO, 7UCSF, SF, CA, 8Methodist, Houston, TX, 9Cleveland Clinic, Cleveland, OH, 10Mount Sinai, NY, NY, 11U Nebraska, Omaha, NE, 12Mayo, Jacksonville, FL, 13Cleveland Clinic, Weston, FL, 14Lahey, Burlington, MA, 15Indiana U, Indianapolis, IN, 16Vanderbilt, Nashville, TN, 17Ochsner, New Orleans, LA

    *Purpose: Ex vivo end ischemic hypothermic oxygenated machine perfusion (HOPE) is a simple technique to improve liver transplant (LT) results and the donor shortage. HOPE…
  • 2022 American Transplant Congress

    Deceased Donor Organ Flush with Similar Volumes of HTK and UW at a Single U.S. Organ Procurement Organization: Adult and Pediatric Data

    A. E. Mangus1, C. Kubal2, B. Ekser3, P. Mihaylov4, A. J. Lutz1, J. Fridell5, R. Mangus6

    1Indiana University Purdue University of Indianapolis, Indianapolis, IN, 2Indiana University Hospital, Indianapolis, IN, 3Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, 4Indiana Univ School of Medicine, Indianapolis, IN, 5Indiana University School of Medicine, Indianapolis, IN, 6Indiana University, Indianapolis, IN

    *Purpose: Histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solutions are the two primary solid-organ preservation solutions used in the United States (>95%), but flush volumes…
  • 2022 American Transplant Congress

    A Multicenter Randomized Controlled Trial To Compare The Efficacy Of Ex-vivo Machine Perfusion With Static Cold Storage In Human Liver Transplantation: The University Of Maryland Experience

    J. Avruch1, N. Goussous2, S. Malik1, M. Pinedo1, R. Meier1, C. Bhati1, D. Maluf1, R. Barth3, J. Alvarez-Casas1

    1Transplant Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Transplant Surgery, University of California Davis Health, Davis, CA, 3University of Chicago, Chicago, IL

    *Purpose: There is accumulating clinical evidence of the benefit of normothermic ex-vivo machine perfusion (NMP) compared with traditional static cold storage of liver allografts prior…
  • 2022 American Transplant Congress

    Characterization of Acute Kidney Injury in Fatty Liver Ischemia Reperfusion Injury

    Z. P. Rokop, W. Zhang, N. Ghosh, A. Das, N. Biswas, C. Sen, C. Kubal

    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN

    *Purpose: The association between hepatic ischemia reperfusion injury (hIRI) and acute kidney injury (AKI) has been well established. AKI is commonly observed following transplantation of…
  • 2022 American Transplant Congress

    HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels

    C. OBrien1, P. Hernandez1, S. Concors2, Z. Wang1, G. Ge3, A. Kozikowski4, W. Hancock5, M. Levine2

    1Surgery, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Surgery, University of Pensylvania, Philadelphia, PA, 4College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 5Childrens Hospital of Philadelphia, Philadelphia, PA

    *Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
  • 2022 American Transplant Congress

    Ultrasound Targeted Microbubble Cavitation During Ex Vivo Normothermic Machine Perfusion Reduces Peribiliary Vascular Plexus Thrombi and Graft Injury in a DCD Liver Transplant Model

    Y. Nigmet1, C. Hughes1, X. Chen2, A. Demetris3, D. Stolz4, J. Pacella2, A. Humar5, F. Villanueva2

    1Transplant Surgery, University of Pittsburgh, Pittsburgh, PA, 2Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, PA, 3Transplant Pathology, University of Pittsburgh, Pittsburgh, PA, 4Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA, 5Thomas E Starzl Transplant Inst, Pittsburgh, PA

    *Purpose: Thrombus formation in the peribiliary vascular plexus (PBP) is a proposed mechanism for ischemic cholangiopathy (IC) after liver transplantation from donors after circulatory death…
  • 2022 American Transplant Congress

    Organ Care System Use in Liver Transplantation Shifts Preservation-Reperfusion Injury in Time and Space

    A. J. Demetris, M. A. Wood-Trageser, D. Lesniak, -. The PROTECT Investigators

    Department of Transplant Pathology, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Liver allograft ischemia-reperfusion injury (IRI) causes early allograft dysfunction (EAD). The TransMedics Organ Care System (OCS) PROTECT trial for liver transplantation (NCT02522871) revealed that…
  • 2022 American Transplant Congress

    Prolonged Preservation by Hypothermic Machine Perfusion Facilitates Logistics in Liver Transplantation: A European Observational Cohort Study

    I. M. Brüggenwirth1, M. Mueller2, V. A. Lantinga1, S. Camagni3, R. De Carlis4, L. De Carlis5, M. Colledan6, D. Dondossola7, M. Drefs8, J. Eden2, D. Ghinolfi9, D. Koliogiannis10, G. Lurje11, T. Manzia12, D. Monbaliu13, P. Muisean14, D. Patrono15, J. Pratschke16, R. Romagnoli17, M. Rayar18, F. Roma14, A. Schlegel2, P. Dutkowski2, R. J. Porte1, V. E. de Meijer1

    1University Medical Center Groningen, Groningen, Netherlands, 2University Hospital Zurich, Zurich, Switzerland, 3ASST Papa Giovanni XXIII, Bergamo, Italy, 4ASST Grande Ospedale Metropolitano Niguarda, Niguarda, Italy, 5Niguarda Ca’ Granda Hospital, Niguarda, Italy, 6Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy, 7Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy, 8University of Munich, Munich, Germany, 9Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, 10Hospital of the University of Munich, Munich, Germany, 11Charité Universitätsmedizin Berlin, Berlin, Germany, 12Tor Vergata University, Rome, Italy, 13KU Leuven University Hospitals Leuven, Leuven, Belgium, 14Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, 15A. O. U. Città della Salute e della Scienza di Torino, Turin, Italy, 16Charite Universitatsmedizin Berlin, Berlin, Germany, 17AOU Città della Salute e della Scienza di Torino, Turin, Italy, 18CHU Pontchaillou, Rennes, France

    *Purpose: A short period (1-2 hours) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver…
  • 2021 American Transplant Congress

    The Harmful Effect of Retained Peripheral Cells During Flushing and Static Cold Storage in Rat Liver Normothermic Machine Perfusion

    O. Haque1, C. A. Pendexter2, J. F. Markmann2, K. Uygun2, H. Yeh2, S. N. Tessier2

    1Surgery, Beth Israel Deaconess Medical Center, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Retained donor blood in a liver graft can cause damage to resident cells that is exacerbated by static cold storage (SCS), leading to platelet…
  • 2021 American Transplant Congress

    Hepatic Ferroptosis in Cold Stress and Warm Ischemia-reperfusion: A Novel Therapeutic Target in Liver Transplantation

    H. Kojima1, H. Hirao1, K. Kadono1, T. Ito1, K. J. Dery1, S. Kageyama2, K. Nakamura3, F. M. Kaldas1, D. G. Farmer1, J. W. Kupiec-Weglinski1

    1UCLA Medical Center, Los Angeles, CA, 2Kyoto University, Kyoto, Japan, 3Nishi-Kobe Medical Center, Kyoto, Japan

    *Purpose: Ferroptosis, a newly discovered programmed cell death platform, due to iron-dependent accumulation of lipid peroxides, has been reported to aggravate ischemia-reperfusion (IR) injury in…
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