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Articles tagged "Liver failure"

  • 2020 American Transplant Congress

    Acute on Chronic Liver Failure (ACLF) Patients Have a Dynamic and Progressive Clinical Course Until Receiving a Liver Transplant: A 5-Year Study at the National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico

    E. Cervantes-Alvarez1, M. J. Lizardo-Thiebaud1, E. Alatorre-Arenas1, O. Mendez-Guerrero1, S. Yarza-Regalado1, A. Torre1, M. Vilatobá2, D. Kershenobich1, C. A. Huang3, N. Navarro-Alvarez1

    1Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 3Surgery, University of Colorado Anschutz Medical Campus, DENVER, CO

    *Purpose: To characterize the clinical course of patients diagnosed with acute on chronic liver failure (ACLF) before undergoing liver transplantation. ACLF is characterized by an…
  • 2020 American Transplant Congress

    Galectin-3 as a Biomarker of Disease Severity in Acute-on-Chronic Liver Failure

    E. Cervantes-Alvarez1, F. Tejeda-Dominguez2, M. Lizardo-Thiebaud2, E. Alatorre-Arenas3, O. Méndez-Guerrero1, S. Yarza-Regalado1, D. Kershenobich1, A. Torre1, M. Vilatobá4, C. A. Huang5, N. Navarro-Alvarez1

    1Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Molecular Biology, Panamerican University, School of Medicine, Mexico City, Mexico, 3University of the Americas Puebla, School of Medicine, Puebla, Mexico, 4Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 5Surgery, University of Colorado Anschutz Medical Campus, Denver, CO

    *Purpose: A matter of great importance is the discovery of alternative diagnostic measures that can detect liver disease at an early stage, especially when at…
  • 2020 American Transplant Congress

    Rare Genetic Mutation Triggering Acute Liver Failure in a Toddler Needing a Liver Transplant

    C. B. Chen1, N. Mistry Ambani1, A. Zeft1, R. Garcia-Naviero2, V. Hupertz1, K. Hashimoto1, K. Radhakrishnan1

    1Cleveland Clinic, Cleveland, OH, 2Akron Children's Hospital, Akron, OH

    *Purpose: The AIRE gene plays an important role in immune tolerance by driving negative selection of self-recognizing T-cells. Mutations in this gene are responsible for…
  • 2020 American Transplant Congress

    In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury

    C. S. OBrien1, P. T. Hernandez1, S. J. Concors1, L. N. Krumeich1, Z. Wang1, G. Ge1, T. Bhatti2, A. Kozikowski3, W. Hancock2, M. H. Levine1

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA, 2Department of Pathology, Children's Hospital of Pennsylvania, Philadelphia, PA, 3Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL

    *Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…
  • 2020 American Transplant Congress

    Ex-Vivo Perfusion with UW Cold Storage Solution Improves DCD Rat Liver Preservation

    R. Fyffe-Freil, N. Wickramaratne, J. Khoraki, H. Kang, C. Chmielewski, R. Li, M. J. Mangino

    Surgery, Virginia Commonwealth University, Richmond, VA

    *Purpose: The donor pool of livers can be expanded by the successful use of donor livers recovered under DCD conditions. It is assumed that perfusion…
  • 2019 American Transplant Congress

    Liver Transplantation for Acute Liver Failure: A 16 Year Experience with 214 Patients in the Post-MELD Era

    R. McMillan, T. Ito, A. Aziz, A. Amin, A. Murray, J. DiNorcia III, V. G. Agopian, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas

    Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Liver transplantation (LT) remains the gold standard treatment for acute liver failure (ALF). Our center has previously reported outcomes in the pre-Model for End…
  • 2019 American Transplant Congress

    Patterns Of Anti-retroviral Use Among U.s. Liver Transplant Candidates With Hiv

    A. A. Shaffer1, A. G. Thomas2, D. L. Segev3

    1Johns Hopkins University, Baltimore, MD, 2Epidemiology, University of North Carolina, Chapel Hill, NC, 3Surgery & Epidemiology, Johns Hopkins University, Baltimore, MD

    *Purpose: There is a high burden of liver disease among HIV-infected (HIV+) individuals, and the class of antiretroviral therapy (ART) used for their treatment may…
  • 2019 American Transplant Congress

    The Experience of Somatostatin to Prevent Small-for-Size Syndrome in Patients with Small Graft in Living Donor Liver Transplantation

    D. Kim, K. Yoon, H. Jo, W. Kang

    Korea University College of Medicine, Seoul, Korea, Republic of

    *Purpose: The small-for-size syndrome has to be overcome especially in living donor liver transplantation (LDLT) considering the graft and patient survival and morbidities. We introduce…
  • 2019 American Transplant Congress

    Higher Incidence of Coagulation Complications in Live Liver Donation

    B. Movahedi, p. Mahboub, N. Kim, P. Martins, A. Bozorgzadeh

    Surgery, UMass Memorial Medical Center, Worcester, MA

    *Purpose: Live donor liver and kidney donations are very effective procedures to increase the available organ pool and shorten waiting list for the patients listed…
  • 2019 American Transplant Congress

    Hyperglycemia Aggravates Acute Liver Injury by Promoting Macrophage NLRP3 Activation via AMPK/mTOR-Dependent Autophagy Inhibition

    H. ZHOU, Q. Wang, R. Liu, S. Zhou, F. Cheng, X. Wang, L. Lu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: The detrimental effects of diabetes mellitus/hyperglycemia include an increase in the oxidative stress response and an enhanced inflammatory response. Despite an increased understanding of…
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