ATC Abstracts

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Articles tagged "Lipids"

  • 2019 American Transplant Congress

    Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration

    Y. Xiong1, W. Piao1, C. Brinkman1, J. Kulinski2, A. Olivera2, A. Cartier3, T. Hla4, K. Hippen5, B. Blazar5, S. Schwab6, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2NIH, Bethesda, MD, 3Boston Children's hospital, Boston, MA, 4Boston Children's hospital, Boston, MD, 5U.Minnesota, Minneapolis, MN, 6NYU, NY, NY

    *Purpose: CCR7 plays critical roles in T cell migration to CCL21 across lymphatic endothelial cells from tissues to lymph nodes (LN). S1PR1 and S1PR4 are…
  • 2019 American Transplant Congress

    S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics

    Y. Xiong1, W. Piao1, C. Brinkman1, L. Li1, J. Kulinski2, A. Olivera2, A. Cartier3, T. Hla4, K. Hippen5, B. Blazar6, S. Schwab7, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2NIH, Bethesda, MD, 3Boston Children's hospital, Boston, MA, 4Boston Children's, Boston, MA, 5U.Minnesota, Minneapolis, MN, 6U.Minnesota, Minneapolis, MD, 7NYU, NY, NY

    *Purpose: T cells utilize S1PR1 to traffic from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether T cell S1PR1 and S1PR4 regulate…
  • 2019 American Transplant Congress

    Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion

    S. Raigani1, N. Karimian2, V. Huang2, S. Geerts2, S. Nagpal2, K. Uygun1, M. Yarmush1, H. Yeh1

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA, 2Center for Engineering in Medicine, Shriners Childrens Hospital, Boston, MA

    *Purpose: Nearly 40-60% of discarded livers are due to steatosis because of poor recovery from ischemia-reperfusion injury and compromised post-transplant function. We evaluated steatotic (ST)…
  • 2019 American Transplant Congress

    Transplant Provider Adherence to Cardiovascular Disease Primary Prevention Guidelines in Liver Transplant Recipients

    M. Kosirog1, P. T. Campbell1, S. Montag2, S. Connolly1, A. Daud3, A. Das1, S. Pine1, D. Finn3, J. Levitsky1, J. L. Holl4, D. M. Lloyd-Jones5, L. B. VanWagner6

    1Division of GI and Hepatology, Department of Medicine, Northwestern Medicine, Chicago, IL, 2Department of Preventative Medicine, Northwestern Medicine, Chicago, IL, 3Center for Healthcare Studies, Northwestern Medicine, Chicago, IL, 4Department of Pediatrics and Center for Healthcare Studies, Northwestern Medicine, Chicago, IL, 5Department of Preventive Medicine and Division of Cardiology, Department of Medicine, Northwestern Medicine, Chicago, IL, 6Division of GI and Hepatology, Department of Medicine and Department of Preventive Medicine, Northwestern Medicine, Chicago, IL

    *Purpose: Blood pressure (BP) control, aspirin, and statin use are modifiable risk factors for primary prevention of atherosclerotic cardiovascular disease (ASCVD), stroke, and heart failure…
  • 2017 American Transplant Congress

    CD4 T Cell Migration Across Lymphatic Endothelium Is Enhanced by Sphingosine 1-Phosphate (S1P) and Differentially Regulated by S1P Receptors (S1PR).

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1UMB, Baltimore; 2UM, Minneapolis

    Introduction: S1PR1 drives T cells to migrate from thymus to blood, and from lymph node (LN) to efferent lymphatics. Whether S1PR1 or other S!PRs regulate…
  • 2017 American Transplant Congress

    Evolution of Lipid Profile and Major Adverse Cardiac Events in Kidney Transplant Recipients Converted from Calcineurin Inhibitor to Everolimus: 24-Month Subanalysis from Elevate Study.

    M. van der Giet,1 J. de Fijter,1 F. Oppenheimer,1 G. Russ,1 P. Lopez,2 G. Bader,2 J. Cruzado,1 H. Holdaas.1

    1ELEVATE Study Group, Berlin, Germany; 2Novartis Pharma AG, Basel, Switzerland

    PURPOSE: Posttransplant (post-Tx) lipid abnormalities may increase risk of cardiovascular (CV) events in kidney transplant recipients (KTxR). Previous analysis from ELEVATE (NCT01114529) study confirmed that…
  • 2017 American Transplant Congress

    Lipid Catabolism Provides Alternative Energy Source and Compensates for Mitochondrial Dysfunction in Reperfused Rat Kidneys After Ischaemia.

    H. Huang,1,2 L. van Dullemen,3 M. Akhtar,1 M. Lo Faro,1,2 A. Dona,4 M. Kaisar,1,2 H. Leuvenink,3 B. Kessler,2 R. Ploeg.1

    1Oxford Transplant Centre, NDS, University of Oxford, Oxford, United Kingdom; 2Target Discovery Institute, NDM, University of Oxford, Oxford, United Kingdom; 3Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; 4Department of Surgery and Cancer, Imperial College London, London, United Kingdom

    Introduction: To reduce morbidity and mortality on the wait list for kidney transplantation, centres are required to use older and higher risk organs including unstable…
  • 2017 American Transplant Congress

    Lipid Abnormalities and Cardiovascular Events After Early Conversion to Everolimus in Kidney Transplant Recipients with Pretransplant Diabetes: 24-Month Analysis from Elevate Study.

    M. van der Giet,1 J. de Fijter,1 F. Oppenheimer,1 G. Russ,1 P. Lopez,2 G. Bader,2 J. Cruzado,1 H. Holdaas.1

    1ELEVATE Study Group, Berlin, Germany; 2Novartis Pharma AG, Basel, Switzerland

    PURPOSE: Pretransplant (preTx) diabetes is an independent risk factor for cardiovascular (CV) events, and posttransplant (post-Tx) hyperlipidemia further increases CV risk. To analyze the influence…
  • 2016 American Transplant Congress

    CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.

    J. Burg,1 T. Andoh,2 N. Haese,2 C. Kreklywich,2 K. Watters,3 T. Metz,3 S. Orloff,1 D. Streblow.2

    1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR; 3Biological Sciences Division, PNNL, Richland, WA.

    PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…
  • 2016 American Transplant Congress

    Higher Pre-Transplant HDL Levels Are Associated with Decreased Acute Rejection Following Kidney Transplant.

    J. Hagopian,1 D. Brennan,2 K. Lentine,3 T. Horwedel.1

    1Barnes Jewish Hospital, St. Louis; 2Washington University, St. Louis; 3Saint Louis University Center for Transplant Research, St. Louis.

    Purpose: Dyslipidemia is a common comorbidity in patients on the transplant waitlist and post-transplant, and hyperlipidemia has been associated with more robust immune response, possibly…
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