2018 American Transplant Congress
Targeting Lymphotoxin Signaling in Lymphatics Regulates Immune Sensitization, Elicitation, and Resolution
Background:Contact hypersensitivity (CHS) is a T cell-mediated cutaneous inflammatory response which includes three phases of priming/sensitization, elicitation, and resolution,mirroring many aspects of allogeneic responses. The…2017 American Transplant Congress
Novel Cell Intrinsic Role of the Adaptor Protein TSAd in Maintaining Alloimmune T Regulatory Cell Function.
TSAd is an SH2 domain containing intracellular adapter molecule that functions to elicit T cell receptor-mediated signals and cytokine production. TSAd knockout (KO) T cells…2017 American Transplant Congress
Role of Chemokines in Resolution of BK Virus-Associated Nephropathy and Chronicity of Pathology Changes in Kidney Transplant Recipients.
David Geffen School of Medicine at UCLA, Los Angeles, CA
BK virus-associated nephropathy (BKN) remains the most common infectious cause of allograft loss after kidney transplantation. We previously demonstrated increased frequency of polyfunctional T cells…2017 American Transplant Congress
IL-3 Contributes to Development of Basophil-Triggered Cardiac Allograft Fibrosis Development.
Introduction: Organ fibrosis and vasculopathy are major causes of chronic cardiac allograft failure. Resident (donor-derived) fibroblasts are thought to be mainly responsible for excessive production…2017 American Transplant Congress
Anti-HLA I Antibody Enhances Endothelial Cell-Induced Polarization of Human Monocytes to M2a/c-Like Macrophages.
HLA antibody (Ab)-mediated rejection (AMR) is often characterized by graft-infiltrating macrophages, which correlate with tissue fibrosis. Recent studies suggest they may mainly represent M2-polarized macrophages.…2017 American Transplant Congress
Low Level Light Laser Treatment Reduces Macrophage Retention and ROS Levels Following Tissue Injury.
1University of Illinois, Chicago; 2Rush University, Chicago
Following ischemia reperfusion injury, inflamed macrophages switch from oxidative phosphorylation to glycolysis; in contrast, macrophages associated with tissue repair rely on oxidative phosphorylation. The triggers…2016 American Transplant Congress
Microfluidics to Characterize Leukocyte Trafficking into Allografts and the Resolution of Inflammation.
1Transplant Research Program, Boston Children's Hospital, Boston; 2MGH, Boston.
Pro-resolution mediators such as resolvins and axonal guidance receptor-ligand interactions are increasingly recognized to regulate leukocyte trafficking into sites of inflammation. The implication of this…2016 American Transplant Congress
A Unique In Vitro Migration Model for Leukocyte Trans-Lymphatic Endothelial Migration.
1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.
Trans-endothelial migration (TEM) is an essential process for leukocyte circulation. While much is known about lymphocyte blood to tissue migration, far less is known about…2016 American Transplant Congress
Matrix Metalloproteinase-2 (MMP-2) Activity Protects Against Hepatic Ischemia Reperfusion Injury Through MMP-9-Dependent and MMP-9-Independent Mechanisms.
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix Metalloproteinases (MMPs) are a family of proteinases with key roles in tissue homeostasis, inflammation and repair. We have recently shown that MMP-9 and MMP-2,…2016 American Transplant Congress
Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Protects Against Loss of Hepatic Integrity After Ischemia-Reperfusion Injury.
Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation (OLT). Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix (ECM)-associated protein…
American Transplant Congress abstracts