2019 American Transplant Congress
Myeloid Derived Suppressor Cells (MDSC) Home to the Allograft and Can Control T Cell Responses
University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are a naturally occurring, heterogeneous population of highly immunosuppressive CD11b+GR-1+ myeloid cells that expand in response to inflammatory conditions. Although…2019 American Transplant Congress
Leukopenia in Older Kidney Transplant Recipients is Associated with Decreased Allograft Survival and Increased Patient Survival
Transplant Nephrology, Medical University of South Carolina, Charleston, SC
*Purpose: Older kidney transplant recipients are vulnerable to side effects of immunosuppression (IS) including leukopenia. Providers often reduce MMF dose in response to leukopenia. This…2019 American Transplant Congress
Leukopenia at the Time of Liver Transplantation: Medication Tolerance and Clinical Outcomes
*Purpose: Leukopenia post-orthotopic liver transplant (OLT) is associated with an increased incidence of infection and mortality. Prior to OLT, leukopenia may suggest innate immunosuppression and…2019 American Transplant Congress
ECDI-Treated Donor Leukocytes in Primate Cardiac Allograft Recipients
*Purpose: Ethyl carbodiimide (ECDI)-fixed donor leukocytes exhibit tolerogenic immunomodulation in murine models of autoimmunity and transplantation, and nonhuman primate islet transplantation. Here in pilot studies…2019 American Transplant Congress
Inhibition of Sialidase Activity and Galectin Binding Reduces Xenogeneic Neutrophil-Endothelial Adhesion
*Purpose: Immediate neutrophil sequestration occurs despite genetic modifications (Gal-a-1-3 galactosyl transferase knock out; human CD46 complement regulatory gene addition) to pig donor organs. Sialic acids…2019 American Transplant Congress
Recipient Myeloid Notch1 Disruption Shifts Neutrophil towards Anti-Inflammatory Phenotype and Protects Liver Grafts from Ischemia-Reperfusion Injury
*Purpose: Liver ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection crises in orthotopic liver transplantation (OLT). We…2019 American Transplant Congress
Donor Derived Cell Free DNA Initiates De-Novo Donor Specific Antibody (DSA) Responses
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury, may contribute to sensitization of the recipients’ immune system. Antigenic presentation of donor-derived nucleic acids,…2019 American Transplant Congress
Local IL-33 Regulates Heart Transplant Infiltrating Myeloid Cells Metabolism and Differentiation to Protect against Chronic Rejection
*Purpose: Self-molecules containing damage-associated molecular patterns stimulate the pro-inflammatory response of infiltrating innate immune cells after their release during tissue injury. Yet, if local endogenous…2019 American Transplant Congress
Timing and Donor-Specific Antibodies, but Not C4d Deposition, Determine Leukocyte Infiltration in Renal Allograft Biopsies with the Histological Picture of Antibody-Mediated Rejection
*Purpose: Diagnosis of antibody-mediated rejection following kidney transplantation can be challenging, given the limited specificity of individual histological parameters and time-dependent occurrence of histological confounders.…2018 American Transplant Congress
Elucidating Novel Signatures of Allograft Rejection through Cytometry by Time of Flight (CyTOF) in Kidney Transplant Recipients
Mass cytometry by time-of-flight (CyTOF) permits the simultaneous assessment of over 40 functional and phenotypic parameters at the single-cell level. This novel tool holds tremendous…
American Transplant Congress abstracts