2020 American Transplant Congress
Immune Cell Subset Profiles in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
*Purpose: IL-6, B cell growth factor, increases follicular T helper cell (Tfh) activity, promoting plasmablast (PB) and plasma cell (PC) differentiation, and antibody production. A…2020 American Transplant Congress
Pre- And Post-Transplant (Tx) Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Treatment Increased Regulatory T Cell (Treg) Percentage in CD4+ T Cells in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts)
*Purpose: IL-6 is a B cell growth factor and pro-inflammatory cytokine. Inhibition of IL-6 signaling modulates B cell activation and inflammatory process possibly through Treg…2020 American Transplant Congress
Mechanisms by Which Donor Bone-Marrow CXCR4+ Foxp3+ Tregs Promote Long-Term Survival of Murine Limb Allografts
*Purpose: Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance…2020 American Transplant Congress
Filgrastim Utilization Evaluation in Solid Organ Transplant Recipients
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Neutropenia occurs in up to 40% of kidney and liver transplant (txp) recipients and has been associated with higher mortality rates in liver txp.…2020 American Transplant Congress
Recipient Myeloid Cell Myeloperoxidase is Required for Nk Cell Activation During Antibody-Mediated Allograft Rejection
Immunology, Cleveland Clinic Lerner Research Institute, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…2020 American Transplant Congress
Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…2019 American Transplant Congress
Inhibition of Sialidase Activity and Galectin Binding Reduces Xenogeneic Neutrophil-Endothelial Adhesion
*Purpose: Immediate neutrophil sequestration occurs despite genetic modifications (Gal-a-1-3 galactosyl transferase knock out; human CD46 complement regulatory gene addition) to pig donor organs. Sialic acids…2019 American Transplant Congress
Recipient Myeloid Notch1 Disruption Shifts Neutrophil towards Anti-Inflammatory Phenotype and Protects Liver Grafts from Ischemia-Reperfusion Injury
*Purpose: Liver ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection crises in orthotopic liver transplantation (OLT). We…2019 American Transplant Congress
Donor Derived Cell Free DNA Initiates De-Novo Donor Specific Antibody (DSA) Responses
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury, may contribute to sensitization of the recipients’ immune system. Antigenic presentation of donor-derived nucleic acids,…2019 American Transplant Congress
Local IL-33 Regulates Heart Transplant Infiltrating Myeloid Cells Metabolism and Differentiation to Protect against Chronic Rejection
*Purpose: Self-molecules containing damage-associated molecular patterns stimulate the pro-inflammatory response of infiltrating innate immune cells after their release during tissue injury. Yet, if local endogenous…
American Transplant Congress abstracts