Articles tagged "Kidney/pancreas transplantation"

2017 American Transplant Congress
Outcome of Systemic Monitoring of DSA and Protocol Management to Optimize Renal Allograft Outcome in a Single Transplant Center.
S. Chang,¹ I. Mallawaarachchi,² C. Yip,¹ T. Shanahan,³ A. Gundroo,¹ A. Dwivedi,² S. Patel,⁴ M. Zachariah.¹
¹Internal Medicine, University of Buffalo, Buffalo, NY; ²Biomedical Sciences, Texas Tech University, El Paso, TX; ³IMMCO Diagnostics, Buffalo, NY; ⁴Surgery, University of Buffalo, Buffalo, NY
Denovo (dn) donor specific antibody (DSA) development has been shown to adversely affect long-term allograft survival. To improve graft outcome for kidney (K) transplant (Tx)…
2017 American Transplant Congress
Factors in Association with Sepsis Differ Between Simultaneous Pancreas/Kidney and Single Kidney Transplant Recipients.
T. Schachtner,^1,2,3 M. Zaks,¹ A. Kahl,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Charite and Max-Delbrück Center, Berlin Institute of Health BIH, Berlin, Germany
As immunosuppressive therapy and allograft survival have improved in simultaneous pancreas/kidney transplant recipients (SPKTRs), the increased incidence of infection has become a major hurdle of…
2017 American Transplant Congress
The Incidence and Outcomes of Fever of Unknown Origin After Pancreas Transplantation.
R. Klasek,¹ S. Kuten,¹ S. Patel,^1,3 D. Nguyen,¹ E. Graviss,¹ A. Gaber,¹ R. Knight.¹
¹Houston Methodist Hospital, Houston, TX; ²Veloxis Pharmaceuticals, Cary, NC
Previous studies have shown that approximately 20% of febrile episodes in transplant recipients are not associated with infection. At our center, fever of unknown origin…
2017 American Transplant Congress
Impact of Pancreas Transplant Failure in Quality of Life in Simultaneous Kidney Pancreas Transplantation.
B. Alharbi, S. Aquil, H. Sharma, O. Ali, P. Luke, A. Sener.
Departments of Surgery and Microbiology and Immunology, Matthew Mailing Center for Translational Transplant Studies, Western University, London, London, ON, Canada
BackgroundBoth kidney and pancreas transplantation have been shown to be associated with improved quality of life (QoL). In fact, one of the most important outcomes…
2017 American Transplant Congress
The Paradox in Pancreas After Kidney Transplantation (PAK): Better Results but Fewer Transplants Despite an Increase in High-Risk Patients.
O. Pankewycz,¹ A. Gruessner,² M. Laftavi,² V. Whittaker,² V. Aggarwal,¹ R. Gruessner.²
¹Medicine, Upstate Medical University, Syracuse, NY; ²Surgery, Upstate Medical University, Syracuse, NY
Background: The number of pancreas transplants performed in the United States peaked in 2004 at 1,483. Since then, pancreas transplant numbers have significantly decreased. Between…
2017 American Transplant Congress
Survival Benefit of Kidney and/or Pancreas Transplantation for Patients with Type 1 Diabetes in the United States.
R. Gruessner,¹ M. Laftavi,¹ O. Pankowycz,² V. Whittaker,¹ Z. Acun,¹ V. Aggarwal,² N. Ozden,² A. Gruessner.¹
¹Surgery, SUNY Upstate Medical University, Syracuse, NY; ²Internal Medicine, SUNY Upstate Medical University, Syracuse, NY
Study Purpose: The purpose of this study was to determine the survival benefit of pancreas and/or kidney transplants as reported over a 28-year time period…
2017 American Transplant Congress
Simultaneous Pancreas and Kidney Transplant (SPK) – The New Standard of Care for Uremic Patients with Type 2 Diabetes Mellitus (T2DM).
A. Gruessner, M. Laftavi, V. Whittaker, Z. Acun, O. Pankowycz, R. Gruessner.
Surgery, SUNY Upstate Medical University, Syracuse, NY
Introduction: While a SPK is now considered standard of care for uremic T1 DM patients, it is not for T2DM (despite similar medical issues). The…
2017 American Transplant Congress
Utility of Concomitant Biopsy in Simultaneous Pancreas Kidney Transplant Recipients in the Identification of Rejection of Pancreas and Kidney.
C. Johnson, K. Johnson, B. Kaplan, M. Temkit, R. Heilman, S. Sukumaran Nair, H. Khamash, J. Huskey, G. Mour, H. Chakkera.
Mayo Clinic Arizona, Phoenix, AZ
Background: In simultaneous pancreas and kidney transplant (SPKTx) recipients, animal studies suggest concordant rejection rates of 88% (ref: Gruessner et al,1994). Limited information is available…
2017 American Transplant Congress
Elevated Serum Lipase Levels in Simultaneous Pancreas and Kidney Transplantation May Indicate Anti-HLA Donor Specific Antibody Response.
B. Javaid, T. Raza, P. Abrams, S. Ghasemian, J. Moore, A. Gilbert, M. Grafals, J. Verbesey, M. Cooper.
Kidney and Pancreas Transplant Program, MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Georgetown University School of Medicine, Washington, DC
Background: Development of anti-HLA donor specific antibodies (DSAs) has been associated with inferior pancreas transplant outcomes. We analyzed data for pancreas and kidney transplant recipients…
2017 American Transplant Congress
Simultaneous Pancreas/Kidney Transplant Recipients Are Predisposed to Symptomatic CMV-Infection and Concomitant Infectious Complications.
T. Schachtner,^1,2,3 M. Zaks,¹ A. Kahl,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Berlin Institute of Health BIH, Berlin, Germany
Infections have increased in simultaneous pancreas/kidney transplant recipients (SPKTRs) with CMV-infection being the most important viral infection with adverse impact on patient and allograft outcomes.…