Articles tagged "Kidney/pancreas transplantation"

2016 American Transplant Congress
Everolimus in Combination with Reduced Dose Tacrolimus Is Effective as a Prophylaxis of Acute Rejection in Low-to-Moderate Immunologic Risk De Novo Kidney Transplantation Patients.
Y. Qazi, F. Shihab, S. Mulgaonkar, K. MaCague, D. Patel.
University of Southern California, Los Angeles; University of Utah, Salt Lake City; Barnabas Health, West Orange; Novartis Pharmaceuticals Corporation, East Hanover.
The US92 study determined whether, in de novo renal transplant patients (pts), concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®…
2016 American Transplant Congress
Is Delayed Graft Function in Simultaneous Kidney-Pancreas Transplant Recipients Associated with an Increased Risk of Pancreas Graft Failure?
S. Singh,^1,2 S. Kim.^1,2,3,4
¹Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Canada; ²Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada; ³Division of Nephrology and the Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, Canada; ⁴Division of Nephrology and the Kidney Transplant Program, St. Michael's Hospital, Toronto, Canada.
Background: Delayed graft function (DGF) in kidney transplant recipients is associated with adverse short and long-term outcomes. However, the impact of DGF of the kidney…
2016 American Transplant Congress
Simultaneous Pancreas and Kidney Transplantation for Type 2 Diabetes.
K. Wong, W. Bry, H. Mahanty, P. Patel.
Transplantation, California Pacific Medical Center, San Francisco, CA.
Introduction: Type 2 diabetes (T2DM) is characterized initially by insulin resistance and later by beta cell failure. Historically, T2DM has been a relative contraindication for…
2016 American Transplant Congress
Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation.
M. Khan,¹ H. El-Hennawy,¹ J. Rogers,¹ A. Farney,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC.
Proposed changes in pancreas transplant (PT) allocation may improve organ sharing but increase cold ischemia time (CIT). Methods: We performed a single center, retrospective study…
2016 American Transplant Congress
How Did the New Kidney and Pancreas Allocation Systems Effect Pancreas Utilization in the First Six-Months?
R. Carrico,¹ J. Fridell,² J. Odorico,³ Z. Stewart.⁴
¹UNOS, Richmond, VA; ²Indiana Univ School of Medicine, Indianapolis, IN; ³Univ of Wisconsin Hospital and Clinics, Madison, WI; ⁴Univ of Iowa Hospital and Clinics, Iowa City, IA.
Background: In 2010 a new pancreas allocation system (PAS) was approved by the OPTN and implemented in October 2014, shortly preceding the new kidney allocation…
2016 American Transplant Congress
Impact of Simultaneous Pancreas-Kidney Transplantation versus Kidney Transplant Alone on Patient and Graft Survival in Type 2 Diabetics with Elevated BMI.
S. Singh,^1,2 S. Kim.^1,2,3,4
¹Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Canada; ²Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada; ³Division of Nephrology and the Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, Canada; ⁴Division of Nephrology and the Kidney Transplant Program, St. Michael's Hospital, Toronto, Canada.
Background: Simultaneous Pancreas-Kidney transplantation (SPKT) is becoming increasingly common in patients with Type 2 diabetes (T2DM). The BMI threshold for listing for SPKT in this…
2016 American Transplant Congress
Is Facilitated Pancreas Allocation Effective?
R. Carrico,¹ J. Fridell,² J. Odorico,³ S. Niederhaus.⁴
¹UNOS, Richmond, VA; ²Indiana Univ School of Medicine, Indianapolis, IN; ³Univ of Wisconsin Hospital and Clinics, Madison, WI; ⁴Univ of Maryland Medical System, Baltimore, MD.
Background: OPTN policy exists that allows the UNOS Organ Center to facilitate the allocation of a pancreas within 1 hr. of donor surgery, permissible only…
2016 American Transplant Congress
The Impact of One Year Individual or Dual Organ Rejection in Simultaneous Pancreas-Kidney Transplant on Kidney Graft Survival – A UNOS Registry Analysis 2000-2013.
I. Moinuddin,¹ T. Taber,¹ M. Yaqub,¹ O. Adebiyi,¹ M. Mujtaba,¹ J. Chen,² M. Goble,² D. Mishler,¹ J. Fridell,² A. Sharfuddin.¹
¹Medicine/Nephrology, Indiana University, Indianapolis; ²Surgery/Transplant, Indiana University, Indianapolis.
Background: Early Rejection of either organ in Simultaneous Pancreas-Kidney transplants (SPK) is common within the first 1 year. We studied the impact of within 1…
2016 American Transplant Congress
Marked Alterations in Gene Expression in Peripheral Blood Leukocytes of Kidney Transplant (tx) Recipients Following Mycophenolic Acid (MPA) Treatment.
K. Sanghavi,¹ B. Wu,¹ C. Dorr,² A. Muthuswamy,² W. Guan,¹ D. Schladt,² R. Remmel,¹ D. Ilke,³ A. Matas,¹ A. Israni,² W. Oetting,¹ P. Jacobson.¹
¹University of Minnestoa, Minneapolis; ²MMRC, Hennepin County Medical Center, Minneapolis; ³Rho.
MPA exerts its immunosuppressive activity by inhibiting IMPDH2 enzyme, halting DNA synthesis in T and B lymphocytes. Cell culture models have shown MPA effects on…
2016 American Transplant Congress
BK Viremia Surveillance and Management in Simultaneous Pancreas-Kidney Transplants.
S. Westphal, C. Miles.
Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
BK virus nephropathy is an important cause of kidney allograft dysfunction, and the mainstay of management is reduction of immunosuppression. In recipients of multiorgan transplants,…