Articles tagged "Kidney"

2019 American Transplant Congress
Racial Disparity in Pre-Kidney Transplant Work-Up
J. Buggs¹, H. Mohamed², C. Myer³, S. Lloyd⁴, E. Rogers¹, H. Pearson¹, J. Clement¹, D. Zunick¹, A. Kumar², V. Bowers¹
¹Tampa General Hospital, Tampa, FL, ²University of South Florida, Tampa, FL, ³University of Tampa, Tampa, FL, ⁴University of Florida, Gainesville, FL
*Purpose: The purpose of this study was to evaluate the disparity, by race, for pre-kidney transplant work-up completion rates of referred patients.*Methods: We conducted a…
2019 American Transplant Congress
Clazakizumab (CLZ, Anti-IL-6 Monoclonal Antibody) Treatment of Patients (Pts) with Chronic Antibody-Mediated Rejection (cABMR) Reduces Total Immunoglobulin (Ig) and Anti-HLA IgG Antibody Levels
B. Shin, N. F. Ammerman, A. A. Vo, X. Zhang, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: We have recently reported successful use of Tocilizumab (TCZ), an anti-IL-6 receptor (R) monoclonal antibody, for cABMR treatment in HLA-sensitized kidney transplant (KTx) Pts.…
2019 American Transplant Congress
Intrinsic Organ Quality Assessment Using Integrative Short Outcome Prediction Composite Scores
K. Archer¹, V. Bontha², Y. Zhang¹, J. Eason³, A. Bajwa², L. Gallon⁴, E. Akalin⁵, D. Maluf², V. Mas⁶
¹OSU, Columbus, OH, ²UTHSC, Memphis, TN, ³UTHSC Director of Transplant Institute, Memphis, TN, ⁴NWU, Chicago, IL, ⁵Albert Einstein College of Medicine, NYC, NY, ⁶UTHSC Director of Transplant Research Institute, Memphis, TN
*Purpose: Organs discards continue to be high due to lack of accurate tools to assess donor quality and predict organ function.To identify characteristics associated with…
2019 American Transplant Congress
Qualitative Recovery Outcomes of Living Kidney Donors
J. Huang¹, M. Mahoney², J. Buggs¹, E. Rogers¹, A. Kumar³
¹Tampa General Hospital, Tampa, FL, ²University of Florida, Gainesville, FL, ³University of South Florida, Tampa, FL
*Purpose: The purpose of this study was to evaluate the qualitative outcomes of living kidney donors by gender.*Methods: We conducted a retrospective cohort study of…
2019 American Transplant Congress
Clinical Importance of the Updated Oxford Classification in Allograft IgA Nephropathy
S. Park¹, H. Go², C. Baek², J. Jeong¹, Y. Kim¹, Y. Kim¹, Y. Kim², J. Lee³, S. Min¹, J. Ha¹, E. Song¹, Y. Kim¹, S. Park², K. Moon¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Asan Medical Center, Seoul, Korea, Republic of, ³Seoul National University Hospital, Boramae Medical Center, Seoul, Korea, Republic of
*Purpose: An additional investigation on the clinical significance of the updated Oxford classification in allograft IgA nephropathy (IgAN) is warranted.*Methods: We performed a retrospective cohort…
2019 American Transplant Congress
Subclinical Rejection is Common on Surveillance Biopsies in Children with Kidney Transplant
S. Gattis¹, R. Liverman¹, A. Serluco¹, J. Yin¹, J. Hogan², S. Jernigan², R. George², P. D. Winterberg², R. Garro²
¹Children's Healthcare of Atlanta, Atlanta, GA, ²Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
*Purpose: Surveillance biopsies provide the opportunity to identify subclinical rejection and other pathologic changes, yet their utilization varies across pediatric kidney transplant centers. The purpose…
2019 American Transplant Congress
Post-Transplant Lymphoproliferative Disorders in Pediatric Renal Transplant Recipients: Case Series of 5 Patients
M. E. Araujo¹, C. Metran¹, R. Cardoso¹, G. Araujo¹, T. De Paula¹, L. Cristofani², M. F. Pereira³, D. David⁴, A. Watanabe¹
¹Pediatric Nephrology, ICr HC FMUSP, São Paulo, Brazil, ²Pediatric Oncology, ICr HC FMUSP, São Paulo, Brazil, ³Pediatric Infectology, ICr HC FMUSP, São Paulo, Brazil, ⁴Anatomopathology, HC FMUSP, São Paulo, Brazil
*Purpose: Post-transplant Lymphoproliferative Disorders (PTLD) after solid organ transplantation is a complication of chronic immunosuppression (IS) and is generally associated with Epstein Barr virus (EBV)…
2019 American Transplant Congress
Urine Recirculation Maintains Hemodynamics and Enhances Function in Normothermic Kidney Perfusion
A. Weissenbacher¹, C. D. Ceresa², D. Voyce³, J. Hunter², R. Ploeg², C. C. Coussios⁴, P. Friend²
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³OrganOx Limited, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
*Purpose: The purpose was to compare urine recirculation (URC) and urine replacement with Ringer’s lactate in a porcine normothermic kidney perfusion (NKP) model using a…
2019 American Transplant Congress
Minimizing Kidney Ischemia Reperfusion Injury by Transferring Exogenous Mitochondria
A. Bajwa¹, V. Bontha¹, J. Eason², D. Maluf³, V. Mas⁴
¹UT, Memphis, TN, ²Director of Transplant Institute. UTHSC, Memphis, TN, ³UTHSC, Memphis, TN, ⁴Director of Transplant Research Institute. UTHSC, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics with increased mitochondrial swelling and reactive oxygen species (ROS) and ultimately degradation of cellular function. Ischemia followed by reperfusion (IRI)…
2019 American Transplant Congress
Using Ensembles of Machine Learning Classifiers to Maximize the Accuracy and Stability of Molecular Biopsy Interpretation
J. Reeve¹, K. S. Madill-Thomsen², P. F. Halloran and the INTERCOMEX Study Group³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ³University of Alberta, Edmonton AB, AB, Canada
*Purpose: The Molecular Microscope diagnostic system (MMDx), based on microarray gene expression, uses ensembles of machine learning classifiers rather than single genes, gene sets, or…