Articles tagged "Kidney"

2020 American Transplant Congress
Intraoperative Oxygen Delivery and Acute Kidney Injury after Liver Transplantation
W. Kim, H. Lee, H. Yoon, K. Suh
Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Although intraoperative hemodynamic variables were reported to be associated with acute kidney injury (AKI) after liver transplantation, the time-dependent association between intraoperative oxygen delivery…
2020 American Transplant Congress
Introduction of Preemptive Pharmacogenomic Testing in Kidney Transplant Recipients: Early Evaluation of the Clinical Impact of Genomic Guided Tacrolimus Dosing
G. Girone¹, V. Do¹, K. Belfield¹, R. Pulk¹, E. Cohen¹, E. Marin²
¹Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Department of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: Tacrolimus is widely accepted as the mainstay of immunosuppression in solid organ transplant. Inherited differences in CYP3A activity are known to contribute to dosing…
2020 American Transplant Congress
Associations of Chronic Kidney Disease with Temperature, Ancestry and Employment
A. A. Connor, B. I. Shaw, K. V. Ravindra
Surgery, Duke University, Durham, NC
*Purpose: We sought to assess the suggested associations of chronic kidney disease (CKD) of unknown origin, also known as Mesoamerican Nephropathy, with temperature, ancestry and…
2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
A. Angeletti¹, C. Donadei¹, G. Donati¹, G. Di Certo¹, D. Conte¹, L. Gasperoni¹, E. Pelizzaro¹, C. Guglielmo¹, G. Comai¹, P. Cravedi², G. La Manna¹
¹DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, ²DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
2020 American Transplant Congress
Activated CD27⁺CD21^– Subset Dominate the Memory B Cell Response During Antibody-Mediated Rejection of Kidney Allografts
K. Louis¹, E. Bailly¹, C. Macedo¹, M. Marrari¹, M. Yamada¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: The role of alloreactive memory B (mB) cells in the pathogenesis of antibody-mediated rejection (ABMR) is increasingly recognized. Yet, a comprehensive characterization of mB…
2020 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies are Associated with Younger Age and Renal Dysfunction in Pediatric Kidney Transplantation
M. Pearl¹, E. T. Chambers², A. Kirk², R. Garro³, B. L. Warshaw³, P. Grimm⁴, R. Ettenger¹, E. Reed¹
¹UCLA, Los Angeles, CA, ²Duke, Durham, NC, ³Emory, Atlanta, GA, ⁴Stanford, Stanford, CA
*Purpose: The significance of non-HLA antibodies in renal transplantation remains unclear. In small single center retrospective studies, angiotensin II type 1 receptor antibody (AT1R-Ab) has…
2020 American Transplant Congress
Single Cell Analysis of Living Donor Kidneys Characterizes Resident Parenchymal and Immune Populations in Male and Female Donors
C. McEvoy¹, J. Szusz², S. Clotet-Freixas¹, J. An², S. Crome², A. Konvalinka¹
¹Toronto General Hospital Research Institute and UHN Transplant Centre, UHN, Toronto, ON, Canada, ²Toronto General Hospital Research Institute, Dept. of Immunology, UHN Transplant, Toronto, ON, Canada
*Purpose:Understanding the molecular profiles and individual contributions of kidney parenchymal and resident/infiltrating immune cells during homeostasis would facilitate development of treatments for kidney graft disease.…
2020 American Transplant Congress
Incidence of Antibody Mediated Rejection in Living Kidney Transplant Recipients with Sensitizing History
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Regulation, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: A donor-reactive alloimmune memory response can arise from prior exposure to foreign human leukocyte antigen by sensitization history in transplant recipients. Assessing risk levels…
2020 American Transplant Congress
Twice Weekly Valganciclovir for Cytomegalovirus Infection Prophylaxis in Kidney Transplant Recipients with Delayed Graft Function on Hemodialysis
S. A. Mehta¹, A. Katz², R. Dieter², P. Jen², J. Siegfried², J. Papadopoulos², T. Lewis²
¹Infectious Diseases, NYU Langone Health, New York, NY, ²Pharmacy, NYU Langone Health, New York, NY
*Purpose: The incidence of cytomegalovirus (CMV) remains high in the first year following kidney transplantation. Valganciclovir (VGC) is commonly prescribed in the early post-operative period…
2020 American Transplant Congress
XBP1 Modulates Endoplasmic Reticulum and Mitochondria Crosstalk via Regulating NLRP3 Inflammasome in Renal Ischemia/Reperfusion Injury
H. Ni¹, Y. Liu¹, W. Deng¹, J. Zhang², J. Xu¹, W. Zeng¹, N. Gong², Y. Miao¹
¹Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Institute of Organ Transplantation, Key Laboratory of the Ministry of Health and the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: This study aims to investigate the molecular mechanism and function of X-box binding protein 1 (XBP1)- NLR family pyrin domain-containing 3 (NLRP3) signaling which…