Articles tagged "Kidney"

2021 American Transplant Congress
Renal Tubular-cell-specific Urinary Extracellular Vesicles: A Novel Biomarker for Diabetic Nephropathy After Kidney Transplantation
N. Eguchi¹, H. Lau¹, F. Zaldivar², U. G. Reddy³, E. Tantisattamo³, A. Ferrey³, D. Dafoe¹, H. Ichii¹
¹Surgery, University of California Irvine, Orange, CA, ²Pediatric Execise and Genomics Research Center, University of California Irvine, Irvine, CA, ³Medicine, University of California Irvine, Orange, CA
*Purpose: Diabetes(DM) is a leading cause of ESRD among renal transplant recipients(RTRs). However, the kinetics of diabetic nephropathy recurrence after renal transplantation(RT) remains unclear. Currently,…
2021 American Transplant Congress
An Unusual Viral Tropism in a Solid Organ Transplant Recipient
P. Singh, A. Bentall, C. Langstraat, A. Swanson, P. Deziel, Y. Huang, R. Razonable
Mayo Clinic, Rochester, MN
*Purpose: Cytomegalovirus (CMV) tissue-invasive disease occurs in higher proportion in CMV-mismatched kidney transplant recipients (KTxR) with no pre-existing immunity and those who are markedly immunologically-impaired.…
2021 American Transplant Congress
Dosing Weight of Rabbit Antithymocyte Globulin and Outcomes Among Kidney Transplant Patients Treated for Rejection
C. Patton, K. Cunningham, C. D'Agostino, A. Novak, M. Kapugi, K. Lang, C. Kane
Pharmacy, Northwestern Memorial Hospital, Chicago, IL
*Purpose: Rabbit antithymocyte globulin (rATG) is FDA approved for kidney transplant induction therapy and treatment of T-cell mediated rejection (TCMR). While prior studies comparing dosing…
2021 American Transplant Congress
Is There a Role for Pre-Operative Angiographic Kidney Embolization Prior to Allograft Nephrectomy?
M. Jacobs¹, R. Stratta¹, D. Harriman², A. Farney¹, J. Rogers¹, G. Orlando¹, A. Reeves-Daniel¹, C. Jay¹
¹Wake Forest Baptist Health, Winston Salem, NC, ²University of British Columbia, Vancouver, BC, Canada
*Purpose: To determine if morbidity associated with allograft nephrectomy (AN) of a failed or diseased kidney transplant (KT) is improved by pre-operative angiographic kidney embolization…
2021 American Transplant Congress
Obesity is a Risk Factor for Progression to Kidney Transplant Waitlisting After Liver Transplantation
B. Shelton¹, B. Orandi¹, K. Olthoff², E. Pomfret³, K. Forde², D. Sawinski², M. Gray¹, N. Ascher⁴, J. Locke¹
¹University of Alabama at Birmingham, Birmingham, AL, ²University of Pennsylvania, Philadelphia, PA, ³University of Colorado School of Medicine, Aurora, CO, ⁴University of California San Francisco, San Francisco, CA
*Purpose: Non-alcoholic steatohepatitis (NASH) has emerged as a leading cause of cirrhosis, and obesity-associated comorbid conditions, including renal disease have become more prevalent. Obesity predisposes…
2021 American Transplant Congress
Short Term Outcomes in Previously Covid Positive Kidney Transplant Recipients in Pre-vaccine Era
R. Prashar, N. J. Khoury, M. Ramesh, A. K. Patel
Henry Ford Transplant Institute, Detroit, MI
*Purpose: To study clinical characteristics and short-term outcomes in kidney transplant recipients who were previously infected with SARS-CoV-2*Methods: In this retrospective, single-center case-series, we identified…
2021 American Transplant Congress
Impact of Donor Kidney Biopsy on Kidney Yield and Post-Transplant Outcomes
C. Wang¹, J. Wetmore¹, A. Wey², N. Salkowski², J. Snyder², A. Israni¹
¹Nephrology, Hennepin County Medical Center, Minneapolis, MN, ²Scientific Registry of Transplant Recipients, Minneapolis, MN
*Purpose: Kidney procurement biopsy findings, such as Glomerulosclerosis (GS) is frequently used to determine kidney quality, but it remains unclear the degree of GS in…
2021 American Transplant Congress
Long Term Outcomes of Kidney Donors with Fibromuscular Dysplasia
H. N. Adrogue¹, A. Evans¹, S. A. Hebert¹, H. E. Adrogue¹, D. T. Nguyen², D. Murad¹, E. A. Graviss²
¹Medicine, Houston Methodist Hospital, Houston, TX, ²Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: Fibromuscular dysplasia (FMD) is not an infrequent finding during kidney donor evaluation. Current guidelines do not provide any recommendations regarding the use of kidneys…
2021 American Transplant Congress
Urinary Exosome Mrna Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, J. Hurley², V. Tadigotla², A. Alghamdi³, A. Srivastava⁴, C. Coticchia², J. Choi¹, H. Allos⁵, k. yatim⁵, J. Alhaddad⁵, S. Eskandari⁵, P. Chu⁵, A. Mihali⁵, I. Lape⁵, M. Lima Filho⁵, B. Ayoma⁵, A. Chandraker⁵, K. Safa⁶, J. Markmann⁶, L. Riella⁶, R. Formica⁷, J. Skog², J. Azzi⁵
¹Medecine, Brigham and Women Hospital, Boston, MA, ²Exosome Diagnostics, Boston, MA, ³Boston Children Hospital, Boston, MA, ⁴Center for Translational Metabolism and Health, Chicago, IL, ⁵Transplantation Research Center, Boston, MA, ⁶Massachusetts General Hospital, Boston, MA, ⁷Yale School of Medicine, New Haven, CT
*Purpose: Traditional biomarkers currently used to monitor the kidney allograft, such as creatinine and proteinuria, are late markers of injury and lack sensitivity, specificity and…
2021 American Transplant Congress
Real-world Treatment Patterns of Antiviral Agents for Cytomegalovirus Among Adult Kidney Transplant Recipients: A USRDS-Medicare Linked Database Study
A. D. Raval¹, M. Ganz², P. Saravanan², Y. Tang¹, C. A. Santos³
¹Merck & Co., Inc., Kenilworth, NJ, ²Evidera, Inc., Waltham, MA, ³Rush University Medical Center, Chicago, IL
*Purpose: Cytomegalovirus (CMV) is a common viral pathogen among kidney transplant recipients (KTRs). Although guidelines recommend the use of prophylaxis or pre-emptive antiviral (AV) therapy…