Articles tagged "Kidney"

2021 American Transplant Congress
Clazakizumab (clz, Anti-il-6 Antibody) Treatment Affects Il-6/il-6r Signaling by Increasing Soluble Gp130 (sgp130) in Hla-sensitized Kidney Transplant Patients (hs Ktx Pts) Treated for Chronic Antibody-mediated Rejection (cabmr)
B. Shin, S. Ge, A. Jimenez, N. Ammerman, A. Vo, R. Zhang, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Cerritos, CA
*Purpose: IL-6 is a pro-inflammatory cytokine responsible for chronic vascular inflammation and a promising target for cABMR modulation. IL-6/sIL-6R complex initiates more pathogenic trans-signaling pathways…
2021 American Transplant Congress
Wound Infection After Kidney Transplantation: A Single Center Study
A. Demirag, J. Oberholzer, A. Agarwal, B. Rawashdeh, E. McCraken, K. Brayman
Transplantation, University of Virginia Medical Cener, Charlottesville, VA
*Purpose: Wound complications (WC) following kidney transplantation (KTx) consume valuable resources and may be associated with inferior short and long term graft outcomes. Known risk…
2021 American Transplant Congress
The Impact of 4-weeks of Supervised Exercise on Frailty and Lower Extremity (LE) Function in Patients with Advanced Chronic Kidney Disease (CKD)
E. Lorenz, L. Hickson, R. Weatherly, K. Thompson, M. Hogan, C. Kennedy
Mayo Clinic, Rochester, MN
*Purpose: Although frailty is a modifiable risk factor for morbidity and mortality among kidney transplant (KT) candidates, the optimal duration of effective prehabilitation interventions is…
2021 American Transplant Congress
Efficacy of MAU868, a Novel BKV Neutralizing Monoclonal Antibody (mAb), for the Treatment of Severe BK Virus Nephropathy (BKVN) After Kidney Transplant
S. C. Jordan¹, N. Ammerman², M. Toyoda³, K. Lim², J. R. Abend⁴, A. Patick⁵, M. R. Hodges⁵, A. Vo², S. J. Kovacs⁶
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Cedars Sinai Medical Ctr, Los Angeles, CA, ⁴Novartis Institutes for BioMedical Research, Virology Research, Emeryville, CA, ⁵Amplyx Pharmaceuticals, San Diego, CA, ⁶Novartis Institutes for BioMedical Research, Translational Medicine, East Hanover, NJ
*Purpose: BKV reactivation leading to nephropathy and allograft loss in kidney transplant (KT) recipients remains a clinical significant concern. No specific or effective anti-BKV therapies…
2021 American Transplant Congress
Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells
C. Albert¹, L. G. Bracaglia¹, A. Koide², J. DiRito¹, T. Lysyy¹, C. Edwards¹, J. T. Langford¹, D. Haakinson¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober¹, W. M. Saltzman¹, S. Kiode², G. Tietjen¹
¹Yale University, new haven, CT, ²Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, ³University of Cambridge, Cambridge, United Kingdom
*Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
2021 American Transplant Congress
Covid vs Non Covid Pneumonia in Kidney Transplant Recipients
R. Prashar, N. Khoury, P. Shrivastava, S. Yeddula, T. Kitajima, E. Ulrich, M. Ramesh, A. Patel, S. Nagai, M. Samaniego-Picota
Henry Ford Hospital, Detroit, MI
*Purpose: Compare clinical characteristics and outcomes in kidney transplant recipients (KTRs) hospitalized with COVID vs Non COVID Pneumonia.*Methods: This is a retrospective case‐control study examining…
2021 American Transplant Congress
Long Term Outcomes of Kidney Transplantation from Deceased Donors with Terminal Acute Kidney Injury
J. Rogers¹, R. Stratta², A. Farney², G. Orlando², C. Jay², A. Reeves-Daniel³, A. Mena-Gutierrez³, N. Sakhovskaya³, K. Gurung², B. Sharda², J. Rogers²
¹Surgery, Wake Forest School of Medicine, Winston Salem, NC, ²Surgery, Wake Forest Baptist Medical Center, Winston Salem, NC, ³Internal Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC
*Purpose: Long term outcomes of kidney transplantation from deceased donors with terminal acute kidney injury (AKI) are not well defined.*Methods: Single center retrospective review of…
2021 American Transplant Congress
Preempting Misconceptions: An Educational Initiative for Preemptive Kidney Transplant Candidates
T. Menser¹, M. Hobeika², H. Ibrahim², A. Khan¹, B. Cruz², J. Sharp², A. Gaber²
¹Houston Methodist Research Institute, Houston, TX, ²Houston Methodist Hospital, Houston, TX
*Purpose: reemptive living donor kidney transplantation (pLDKT) offers many advantages for patients with advanced chronic kidney disease. However, pLDKT represents less than 1 out of…
2021 American Transplant Congress
De Novo Atypical Hemolytic Uremic Syndrome (aHUS) in Kidney Transplant Recipients from the Same Donor: Possible Role of Two Genetic Hits
C. Crane¹, J. Sherbotie², S. Anand³
¹University of California at San Diego, San Diego, CA, ²University of Utah School of Medicine, Salt Lake City, UT, ³Nephrology Associates of Utah, Salt Lake City, UT
*Purpose: Thrombotic microangiopathy (TMA) is an uncommon and potentially serious complication of kidney transplantation. Atypical hemolytic uremic syndrome (aHUS) is a type of TMA most…
2021 American Transplant Congress
Dynamic Forecasting of Patient-Specific Kidney Transplant Function with a Sequence-to-Sequence Deep-Learning Model
E. Van Loon¹, W. Zhang², A. Van Craenenbroeck¹, B. De Moor², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: Alike other clinical biomarkers, eGFR trajectories are characterized by intra-individual variability, related to biological fluctuations and analytical error. These fluctuations hamper the distinction between…