Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Single Cell Rna-Sequencing of Urinary Cells and Defining the Immune Landscape of Rejection in Human Kidney Allografts
T. Muthukumar¹, H. Yang¹, A. Belkadi², G. Thareja², C. Li¹, C. Snopkowski¹, K. Chen¹, T. Salinas¹, M. Lubetzky¹, J. Lee¹, D. Dadhania¹, K. Suhre², M. Suthanthiran¹
¹Nephrology, NY Presbyterian- Weill Cornell Medical College, New York, NY, ²Physiology and Biophysics, Weill Cornell Medicine-Qatar, Doha, Qatar
*Purpose: Transcriptome-based clustering of urinary cells in kidney transplant recipients may help identify cell-type specific injury and develop cell-type specific biomarkers for the noninvasive assessment…
2021 American Transplant Congress
Successful Long-Term TMA- and Rejection-Free Survival of a Kidney Xenograft With Triple Xenoantigen Knockout Plus Insertion of Multiple Human Transgenes
T. Hirose¹, D. Ma¹, G. Lassiter¹, H. Sasaki¹, I. Rosales², T. Coe¹, C. Rickert¹, R. Matheson¹, R. Colvin², W. Qin³, Y. Kan³, J. Layer³, K. Stiede³, K. Hall³, M. Youd³, W. Westlin³, M. Curtis³, J. F. Markmann¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³eGenesis Inc, Cambridge, MA
*Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. However, anti-porcine natural antibodies of…
2021 American Transplant Congress
Athena – Effect of Primary Immunosuppression on Development of De Novo Donor Specific Antibodies within First Year After Kidney Transplantation
W. Arns¹, A. Philippe¹, V. Ditt¹, I. A. Hauser¹, F. Thaiss¹, C. Sommerer¹, B. Suwelack¹, A. Finkel², C. Schiedel², D. Dragun¹, B. Nashan¹
¹ATHENA, Study Group, Germany, ²Novartis Pharma GmbH, Nuremberg, Germany
*Purpose: The ATHENA trial [NCT01843348] investigated safety and efficacy of everolimus combined with cyclosporine A [EVR/CsA] or tacrolimus [EVR/TAC] vs. tacrolimus plus mycophenolic acid [MPA/TAC]…
2021 American Transplant Congress
Association Between Donor-Recipient Genetic Matching and Acute Rejection in Kidney Transplantation
R. Cao¹, V. Arthur², J. Chen², B. Keating², C. Dorr³, D. Schladt³, G. Onyeaghala³, R. Mannon⁴, A. Matas¹, R. Remmel¹, N. Pankratz¹, B. Wu¹, W. Oetting¹, P. Jacobson¹, A. Israni³, W. Guan¹
¹University of Minnesota, Minneapolis, MN, ²University of Pennsylvania, Philadelphia, PA, ³Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴University of Nebraska, Omaha, NE
*Purpose: In this study we carried out a genome-wide association study (GWAS) between donor-recipient matching scores at individual SNP level and Acute rejection (AR) in…
2021 American Transplant Congress
Sampling Renal Biopsies in Pre-Clinical Research for Comprehensive Assessment
C. M. Edwards¹, C. Albert², D. Stern¹, J. Langford¹, W. Day², J. R. DiRito¹, W. M. Saltzman², M. Kashgarian³, J. S. Pober⁴, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale School of Medicine, New Haven, CT, ³Pathology, Yale School of Medicine, New Haven, CT, ⁴Immunobiology, Yale School of Medicine, New Haven, CT
*Purpose: Previous literature has demonstrated that single biopsies are not representative of a whole kidney in clinical assessments. In this study we aimed to design…
2021 American Transplant Congress
Initial Experience with Trugraf^Tm Gene Expression Profile and Trac^Tm Dd-cfdna Testing in Kidney Transplant Recipients Suggests Synergy and Enhanced Management within the First Year Post-transplant and Beyond
V. Paramasivam, B. Greco, M. Germain
Nephrology, Baystate Medical Center, Springfield, MA
*Purpose: Non-invasive validated rejection biomarkers are now available to monitor kidney transplant patients (KTRs). Two such biomarkers are; TruGrafTM (TG) gene expression profile validated to…
2021 American Transplant Congress
Torque Teno Virus Load Predicts Allograft Rejection but Not Viral Infection After Kidney Transplantation; A Cohort Joint Modelling Study
A. L. van Rijn¹, H. F. Wunderink², I. A. Sidorov¹, C. S. de Brouwer¹, A. C. Kroes¹, H. Putter³, A. P. de Vries⁴, J. I. Rotmans⁴, M. C. Feltkamp¹
¹Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands, ²Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands, ³Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, ⁴Internal Medicine, Leiden University Medical Center, Leiden, Netherlands
*Purpose: The main challenge of immunosuppressive therapy after solid organ transplantation is to find the optimal dose regimen, and prevent allograft rejection as well as…
2021 American Transplant Congress
Covid-19 in a Kidney Transplant Patient Associated with Collapsing Glomerulopathy
W. Hninn, M. Merzkani, H. Murad, A. Malone, A. Java, G. Rajashekar, R. Delos Santos, T. Alhamad
Washington University School of Medicine, St. Louis, MO
*Purpose: Coronavirus- 19 is a novel virus with various clinical presentations ranging from a cold to severe acute respiratory syndrome. However, little is known about…
2021 American Transplant Congress
Evaluation of Low Dose Famciclovir as Herpes Simplex Virus and Varicella Zoster Virus Prophylaxis in Cytomegalovirus Low Risk Solid Organ Transplant Recipients
M. Cote, A. Cubley, C. Rogers, S. Shao, C. N. Kotton
Massachusetts General Hospital, Boston, MA
*Purpose: Famciclovir is recommended for herpes simplex virus (HSV) and varicella-zoster virus (VZV) prophylaxis in cytomegalovirus (CMV) low risk (both donor and recipient CMV seronegative)…
2021 American Transplant Congress
Cytomegalovirus Infection Among Adult Kidney Transplant Recipients: Findings From the USRDS-medicare Linked Database Study
A. Raval¹, M. Ganz², S. Alam², Y. Tang¹, C. Santos³
¹Merck & Co., Inc., Rahway, NJ, ²Evidera-PPD, Waltham, MA, ³Rush University Medical Center, Chicago, IL
*Purpose: Cytomegalovirus infection (CMVi) is a frequent complication and significant cause of morbidity and mortality after kidney transplantation (KT). However, there are limited recent national…