Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Attitudes Regarding Transplantation During the Pandemic: Give Me My Kidney Now!
T. Menser¹, M. Hobeika², A. Gaber², H. Ibrahim²
¹Houston Methodist Research Institute, Houston, TX, ²Houston Methodist Hospital, Houston, TX
*Purpose: The transplant community faces ongoing challenges regarding the conduct of organ transplantation during the COVID-19 pandemic, and patient treatment preferences during the pandemic require…
2021 American Transplant Congress
Integrative Analyses of Circulating Small Rnas and Paired Kidney Graft Transcriptome in Transplant Glomerulopathy
C. Kuscu¹, K. Manjari², M. Akram³, C. Kuscu⁴, A. Wolen,⁴, A. Bajwa⁴, J. Eason⁴, D. G. Maluf⁵, V. Mas⁶, E. Akalin⁷
¹Surgery, James D Eason Transplant Institute, UTHSC, Memphis, TN, ²Department of Systems and Computational Biology, School of Life Sciences, University of Hyderabad,, Hyderabad,, India, ³Center for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN, ⁴Surgery, James D Eason Transplant Institute, Memphis, TN, ⁵Surgery, Program in Transplantation, University of Maryland, Baltimore, MD, ⁶Surgery, Division Surgical Science, University of Maryland, Baltimore, MD, ⁷Medicine, Montefiore Medical Center, Abdominal Transplant Program, Albert Einstein College of Medicine,, NYC, NY
*Purpose: Transplant glomerulopathy (TG) develops through multiple mechanisms including donor-specific antibodies, T cells and innate immunity. We investigate the role of circulating small RNAs (sRNAs)…
2021 American Transplant Congress
Growth Differentiation Factor 15 Predictor Value is Superior to Troponin I in the Evaluation of Kidney Transplant Candidates
M. de Cos Gomez¹, M. Garcia Unzueta², A. Benito Hernandez¹, J. Mazon Ruiz¹, M. Perez Arnedo¹, A. Aguilera Fernandez¹, R. Valero San Cecilio¹, J. Ruiz San Millan¹, E. Rodrigo Calabia¹
¹Nephrology, Marques de Valdecilla University Hospital - IDIVAL, Santander, Spain, ²Clinical Analysis, Marques de Valdecilla University Hospital - IDIVAL, Santander, Spain
*Purpose: Pretransplant cardiac troponin I (cTNI) has demonstrated its predictor value of survival after kidney transplant in previous studies. Growth differentiation factor 15 (GDF-15) is…
2021 American Transplant Congress
The Effect of the Affordable Care Act on Insurance Status, Waitlist, and Transplant Outcomes in Liver Transplantation
B. I. Shaw¹, M. L. Samoylova¹, V. Wang², T. Risoli Jr³, S. Peskoe³, K. Caddell³, L. M. McElroy¹
¹Surgery, Duke University, Durham, NC, ²Population Health Sciences, Duke University, Durham, NC, ³Biostatistics, Duke University, Durham, NC
*Purpose: The Affordable Care Act (ACA) intended to expand Medicaid to cover all adults with income below 138% of federal poverty level. We describe the…
2021 American Transplant Congress
Infectious Complications After Belatacept Conversion in Kidney Transplant
J. E. Marvin¹, D. Amenyedor¹, M. M. Azar², K. Belfield¹, V. Do¹, R. Formica³, E. Cohen¹
¹Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, ³Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: Tacrolimus (tac), a calcineurin inhibitor, is associated with multiple adverse effects when used for immunosuppression following kidney transplant (KT). Belatacept (bela) is a monoclonal…
2021 American Transplant Congress
Tacrolimus Therapeutic Exposure is Not Consistently Predicted by Target Troughs or CYP3A5 Variants in Stable Renal Transplant Recipients
K. Tornatore¹, K. Attwood², D. Brazeau³, B. Murray⁴
¹Pharmacy Practice, School of Pharmacy; University at Buffalo, Buffalo, NY, ²Biostatistics, School of Public Health; University at Buffalo, Buffalo, NY, ³Pharmacy Practice, School of Pharmacy; Marshall University, Huntington, WV, ⁴Medicine, Erie County Medical Center Corp., Buffalo, NY
*Purpose: Tacrolimus (TAC) immunosuppression requires therapeutic trough monitoring post-transplant due to notable interpatient pharmacokinetic(PK) variability which may be attributed to CYP3A5 polymorphisms. We investigated the…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
2021 American Transplant Congress
Disparities in Access to Listing in Rural Populations Post-KAS Implementation
S. H. Nguyen¹, R. R. Redfield², N. Neidlinger¹, D. P. Foley¹, D. B. Kaufman¹, J. T. Adler³
¹Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²Department of Surgery, University of Pennsylvania, Philadelphia, PA, ³Department of Surgery, Brigham and Women’s Hospital, Boston, MA
*Purpose: One major goal of the Kidney Allocation System (KAS) was to improve access to transplantation. The impact of KAS on rural populations has been…
2021 American Transplant Congress
The Trifecta Study: Calibrating Circulating Donor-Derived Cell-Free DNA at the Time of Indication Biopsies Against the Molecular Phenotype of the Biopsy Reveals a Prominent Association with NK Cell Genes
P. Halloran¹, Z. Demko², A. Prewett², J. Reeve¹, P. Billings²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Natera Inc., San Carlos, CA
*Purpose: The international, multicenter, prospective Trifecta study was designed to calibrate dd-cfDNA% measurements in blood at the time of indication biopsy against the molecular characteristics…
2021 American Transplant Congress
Use of Donor Blood Expedites HCV Genotyping and Allows Earlier DAA Initiation for Recipients of HCV+ Kidneys
B. Lonze, N. Ali, R. Montgomery, Z. Stewart Lewis
Tranplant Institute, NYU Langone Health, New York, NY
*Purpose: Utilization of HCV viremic donor kidneys for transplant into HCV naïve recipients has become more widespread, yet best practices governing the initiation, timing or…