Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Treatment of Refractory Chronic Active Antibody-Mediated Rejection: Improvement in Histopathology are Delayed Compared to the Reduction in Donor Specific Antibodies
K. R. Degner¹, S. Parajuli¹, F. Aziz¹, N. Garg¹, M. Mohamed¹, D. A. Mandelbrot¹, S. E. Panzer¹, L. Hidalgo¹, N. A. Wilson¹, S. R. Reese¹, K. Van Hyfte¹, W. Zhong¹, P. Nickerson², A. Djamali¹
¹University of Wisconsin, Madison, WI, ²University of Manitoba, Winnipeg, MB, Canada
*Purpose: There are limited options for the treatment and management of refractory chronic active antibody-mediated rejection (cABMR) after kidney transplantation. Longitudinal histologic data in patients…
2021 American Transplant Congress
Intermediate Outcomes Following Early Inflammatory Changes on Surveillance Biopsies
I. Melgarejo¹, V. Viswanathan², A. Sharma¹, P. Sood¹, C. Puttarajappa¹, N. Shah¹, M. Molinari¹, A. Tevar¹, C. Wu¹, S. Hariharan¹, R. Mehta¹
¹Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Department of Renal-electrolyte, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: The implications on early inflammatory changes on surveillance biopsies on intermediate and long-term outcomes is unclear.*Methods: Of the 1000 kidney transplant (live donor and…
2021 American Transplant Congress
Dialysis Staff-Reported Impact of the Early Covid-19 Pandemic on Kidney Transplant Referrals and Evaluations
A. Perez¹, S. Retzloff¹, T. Browne², A. Cruz³, S. Wright³, S. Pastan⁴, R. Patzer¹
¹Department of Surgery, Emory University School of Medicine, Atlanta, GA, ²College of Social Work, University of South Carolina, Columbia, SC, ³IPRO ESRD Network of the South Atlantic, Morrisville, NC, ⁴Department of Medicine, Emory University School of Medicine, Atlanta, GA
*Purpose: COVID-19 has drastically impacted healthcare systems since its declaration as a pandemic in March 2020. Evidence of this impact persists among solid organ transplant…
2021 American Transplant Congress
Characterization of SGLT2 Inhibitor Use After Abdominal Transplant
F. Hailemariam¹, S. Yeager², J. Schulte³, P. Singh¹, A. Yadav¹
¹Transplant Nephrology, Thomas Jefferson University Hospital, Philadelphia, PA, ²Abdominal Transplant Pharmacist, Thomas Jefferson University Hospital, Philadelphia, PA, ³Abdominal Transplant, Clinical Pharmacist, Thomas Jefferson University Hospital, Philadelphia, PA
*Purpose: Post solid organ transplantation, diabetic kidney disease (DKD) can progress due to recurrent pre-transplantation diabetes or the development of post-transplantation diabetes mellitus (PTDM). This…
2021 American Transplant Congress
Prevalence and Dynamics of SARS-COV-2 IgG in Kidney Transplant Recipients
Y. Al Azzi, P. Loarte, C. Pynadath, O. Alani, L. Liriano-Ward, M. Ajaimy, R. Bartash, J. Graham, M. Le, H. Yaffe, S. Greenstein, J. Rocca, M. Kinkhabwala, E. Akalin
Montefiore Medical Center, New York, NY
*Purpose: We aimed to investigate the prevalence and dynamics of SARS-CoV-2 IgG in kidney transplant recipients in the Bronx, New York, one of the epicenters…
2021 American Transplant Congress
Can Procurement Biopsy Data Tell Us Anything? The Influence of Glomerulosclerosis on Long-term Kidney Graft Survival
D. Stewart¹, L. Kamal², J. Foutz³, H. McGehee³, P. Saravanane², S. Yu², R. Yousfi², G. Gupta²
¹United Network for Organ Sharing, Richmond, VA, ²Virginia Commonwealth University Health, Richmond, VA, ³Research, United Network for Organ Sharing, Richmond, VA
*Purpose: Biopsy findings, particularly % glomerulosclerosis, have been shown to have a profound impact on kidney utilization decisions. Most studies of the association between procurement…
2021 American Transplant Congress
Economic and Clinical Benefit of Cmv Matching in Kidney Transplantation
D. Axelrod¹, S. Chang², A. Olyaei³, D. Malinoski³, D. Norman³, K. Lentine⁴, M. Schnitzler⁴, D. Segev⁵, J. Lockridge³
¹Univ of Iowa, Iowa City, IA, ²Washington Univ, Seattle, WA, ³Oregon Health Sciences Univ, Portland, OR, ⁴Saint Louis Univ, Saint Louis, MO, ⁵Johns Hopkins, Baltimore, MD
*Purpose: Recently, kidney transplant (KTx) centers in Oregon collaborated to preferentially allocate cytomegalovirus-seronegative (CMV D-) kidneys to seronegative recipients (CMV R-), successfully reducing high-risk CMV…
2021 American Transplant Congress
Worsening Impact of Acute Kidney Rejection on Long Term Graft Survival from 2000 to 2014
D. Leeser¹, W. Irish¹, K. Ravindra², V. Villani², A. Connor², J. Tuttle¹
¹Surgery, East Carolina University, Greenville, NC, ²Surgery, Duke University, Durham, NC
*Purpose: Acute rejection (AR) has been shown to impact graft survival after kidney transplant (KTx), however there is limited data on its impact on long…
2021 American Transplant Congress
The Role of Donor-derived Cell-free DNA to Detect Subclinical Acute Rejection in Kidney Allograft
S. Park¹, K. Guo², R. Heilman³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁹, J. Holman¹⁰, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹¹, J. Friedewald¹
¹Transplant nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Transplant nephrology, Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Eurofins US Clinical Diagnostics, Lee’s Summit, MO, ¹⁰Transplant Genomics, Inc, Mansfield, MA, ¹¹University of Arizona College of Medicine, Northwestern University, Tucson, AZ
*Purpose: We hypothesized that donor-derived cell-free DNA (dd-cfDNA) could detect subclinical acute rejection (subAR).*Methods: 429 blood samples paired with surveillance kidney biopsies from 208 patients…
2021 American Transplant Congress
Single-Dose Basiliximab Induction Therapy in Low-Immunologic Risk Kidney Transplant Recipients
A. Hutchins, J. Schoen, J. S. McMullen
Pharmacy, Nebraska Medicine, Omaha, NE
*Purpose: The purpose of this study is to examine the outcomes associated with single-dose basiliximab in low-immunologic risk kidney transplant recipients following a revision to…