Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Desensitization Using Clazakizumab® (anti-il-6) in Highly-hla Sensitized Patients Awaiting Kidney Transplant (nct03380962)
A. A. Vo¹, N. Ammerman¹, E. Huang¹, M. Toyoda², S. Ge², A. Peng¹, R. Najjar¹, S. Sethi¹, S. Williamson¹, C. Myers¹, K. Lim¹, M. Gillespie¹, S. Jordan¹
¹Kidney Transplant, Cedars Sinai Medical Ctr, Los Angeles, CA, ²Transplant Immunology Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 is a critical cytokine for plasma cell IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6. Here…
2021 American Transplant Congress
Response to a Pandemic: The Fall and Rise of Kidney Transplantation in the US
S. Bisen¹, B. Boyarsky¹, W. Werbel¹, J. Snyder², J. Garonzik-Wang¹, D. Segev¹, A. Massie¹
¹JHU, Baltimore, MD, ²SRTR, Minneapolis, MN
*Purpose: During the first wave of the COVID-19 epidemic in March-April 2020, waitlist registrations and living/deceased donor kidney transplants (LDKT/DDKT) dropped substantially. A second wave…
2021 American Transplant Congress
Inflammation in Scarred Cortex (i-IFTA) is Significantly Associated with T Cell-mediated Rejection (TCMR), but Not Antibody-mediated Rejection (ABMR), in Renal Allograft Biopsies (Bx)
H. Zhang
Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: I-IFTA in renal allograft Bx has been found to be associated with decreased death-censored graft survival. Moderate to severe i-IFTA (2 or 3) is…
2021 American Transplant Congress
Extracellular Matrix Injury of Kidney Allografts in Antibody-mediated Rejection
S. Clotet Freixas¹, C. McEvoy¹, I. Batruch², C. Pastrello³, M. Kotlyar³, J. Van¹, M. Arambewela¹, A. Boshart¹, S. Farkona¹, Y. Niu³, Y. Li¹, O. Famure¹, A. Bozovic⁴, V. Kulasingam⁴, P. Chen¹, J. S. Kim¹, E. Chan⁵, S. Moshkelgosha¹, S. A. Rahman⁶, J. Das⁶, T. Martinu¹, S. Juvet¹, I. Jurisica³, A. Chruscinski¹, R. John¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada, ⁶Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Antibody-mediated rejection (AMR) accounts for >50% of kidney graft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in glomeruli…
2021 American Transplant Congress
Journey to Transplant: A Pilot Feasibility Trial of a Virtual Counseling Intervention for Patients and Their Social Support Networks to Improve Access to Kidney Transplant
A. Hart¹, R. Edpuganti², H. D'Cunha², S. Kurschner², W. T. McKinney¹, A. Matas¹, R. Patzer¹, S. Chu¹, M. Bruin¹, M. Partin¹
¹Hennepin Healthcare, University of Minnesota, Minneaplis, MN, ²Hennepin Healthcare Research Institute, Minneaplis, MN
*Purpose: Home counseling interventions have shown promise in increasing rates of kidney transplant, but are challenging to implement. We piloted a structured but individualized virtual…
2021 American Transplant Congress
Primary Uretero-ureterostomy in Renal Transplantation
H. Shokouh-Amiri¹, M. S. Naseer¹, D. Aultman¹, R. McMillan¹, S. Tandukar², F. T. Siskron³, N. Singh², G. Zibari¹
¹Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²Transplant Nephrology, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ³Urology, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Uretero-neocystostomy (UN) is routinely performed in renal transplantation. Few studies of primary uretero-ureterostomy (UU) have been reported, showing its safety and feasibility. If the…
2021 American Transplant Congress
Tacrolimus Shortage and the Rush to Convert: An Unexpected Burden on the System During the Covid-19 Pandemic?
N. Pilch, L. Johnson, M. Aldoughaim, N. Patel, F. Bartlett
Medical University of South Carolina, Charleston, SC
*Purpose: A national shortage of immediate release (IR) tacrolimus (FK) fully impacted our center in May 2020. The conversion process was immediately challenging during the…
2021 American Transplant Congress
CD40/40L Pathway is Critical in Controlling CMV Transmission Following Kidney Transplantation in Immunocompromised Mice
X. Lai¹, L. Qiu², J. Wang¹, L. VanOsdol¹, S. Yan³, M. Kandpal⁴, M. Abecassis⁵, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University, Chicago, IL, ²University of California,, San Francisco, CA, ³Northwestern University, Chicago, IL, ⁴Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁵University of Arizona, Tucson, AZ
*Purpose: We have previously shown that transplant of kidneys from donor mice latently infected with murine cytomegalovirus (CMV) into naïve recipients treated with clinically relevant…
2021 American Transplant Congress
Intraoperative Fluid Management and Kidney Transplantation Outcomes: A Retrospective Review
M. W. Harbell¹, M. B. Kraus¹, S. A. Buckner Petty², J. W. Harbell³
¹Anesthesiology and Perioperative Medicine, Mayo Clinic, Phoenix, AZ, ²Biostatistics, Mayo Clinic, Phoenix, AZ, ³Transplant Surgery, Mayo Clinic, Phoenix, AZ
*Purpose: Patients undergoing kidney transplantation have traditionally received liberal amounts of fluid during surgery to ensure adequate fluid volume and flow to the transplanted kidney.…
2021 American Transplant Congress
Nonadherence Post-kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay
N. Singh¹, A. Palermini¹, M. S. Naseer¹, T. Le¹, S. Tandukar¹, D. Aultman², H. Shokouh-Amiri², G. Zibari²
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Nonadherence to immunosuppression medications is common post-transplantation. We hypothesize that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs) which in…