Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Augmented Responses of Donor Kidney Tubular Cells to TLR Signaling Correlate with Ameliorated Ischemia/reperfusion Injury and Long-term Allograft Protection
X. Lai¹, J. Wang¹, L. Qiu², S. Han¹, K. Shen¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University, Chicago, IL, ²University of California, San Francisco, San Francisco, CA
*Purpose: We have previously demonstrated that donor genetic background and kidney-intrinsic innate immunity were key determinants of delayed graft function in kidney transplantation. However, the…
2021 American Transplant Congress
Blood Gene Expression and Donor-derived Cell Free DNA for Diagnosing Subclinical Acute Rejection in Stable Kidney Transplant Recipients
S. Park¹, K. Guo², H. Raymond³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁸, J. Holman⁹, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹⁰, J. Friedewald¹
¹Transplant Nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Transplant Genomics, Inc, Mansfield, MA, ¹⁰University of Arizona College of Medicine, Tucson, AZ
*Purpose: A blood gene expression profile (GEP) has been established as a non-invasive screen for subclinical acute rejection (subAR). For patients with allograft dysfunction, donor-derived…
2021 American Transplant Congress
Cellular and Genetic Signatures of Operational Tolerance in Kidney Transplant Recipients Through Single Cell R N A Sequencing Analysis
H. BAE¹, H. Lee², J. Ryu³, B. Chung², E. Oh³
¹Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, ²Department of Internal Medicine, Division of Nephrology, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, Seoul, Korea, Republic of, ³Department of Laboratory Medicine, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of
*Purpose: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results. We analyzed differently expressed mRNAs and proteins…
2021 American Transplant Congress
Relationship Between Tacrolimus Blood Levels and Covid-19 Pandemic in Kidney Transplant Recipients
T. Inoue¹, K. Unagami,², A. Ishiwatari³, T. Kanzawa³, T. Shimizu³, K. Omoto³, M. Inui³, T. Suzuki¹, H. Ishida⁴, K. Tanabe³
¹Department of Nephrology, Kameda Medical Center, Chiba Kamogawa, Japan, ²Department of Organ Transplant Medicine, Tokyo Women’s Medical University, Tokyo, Japan, ³Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Department of Organ transplant medicine, Tokyo Women’s Medical University, Tokyo, Japan
*Purpose: The novel coronavirus 2019 infection (COVID-19) caused a pandemic, prompting Tokyo, Japan, to restrict on the free movement of people in March 2020. Kidney…
2021 American Transplant Congress
Management of Asymptomatic Bacteriuria in Kidney Transplant Recipients
A. Diamond
Pharmacy, Temple University Hospital, Philadelphia, PA
*Purpose: Asymptomatic bacteriuria (ASB) is the presence of bacteriuria with no symptoms. Recent guidelines recommend against treatment of ASB in kidney transplant (KT) recipients more…
2021 American Transplant Congress
Impact of Cytomegalovirus Prophylaxis on Herpes Simplex and Varicella Zoster Virus Infections in Kidney Transplant Recipients
K. Ridgely¹, B. Crowther², P. Klem², K. Schoeppler¹, K. Schwarz¹, A. Nadrash², V. Lewis¹, E. Benamu³
¹Department of Pharmacy Services, UCHealth University of Colorado Hospital, Aurora, CO, ²Ambulatory Care Pharmacy Services, UCHealth University of Colorado Hospital, Aurora, CO, ³Department of Medicine, UCHealth University of Colorado Hospital, Aurora, CO
*Purpose: To assess the impact of cytomegalovirus (CMV) targeted antiviral prophylaxis on the development of herpes simplex (HSV) and varicella zoster (VZV) infections after kidney…
2021 American Transplant Congress
Impact of the Kidney Allocation System on Kidney Transplant Outcomes in Patients with Long Dialysis Treatment (> 10 Years)
M. Kadatz, S. Vaishnav, S. Brar, D. Chang, J. Lan, J. Gill
Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada
*Purpose: Prior to the new kidney allocation system (KAS), patients treated with dialysis for > 10 years before transplantation were shown to derive a survival…
2021 American Transplant Congress
Outcomes in Older Recipients Receiving Kidneys from Donors with Acute Kidney Injury (AKI)
S. Nair, K. Reddy, L. Kodali, P. Budhiraja, J. Ninan, C. Jadlowiec, A. Mathur, J. Harbell, H. Khamash, M. Smith, R. Heilman
Mayo Clinic, Phoenix, AZ
*Purpose: Older patients are perceived to tolerate delayed graft function (DGF) poorly and there is a reluctance to transplant a kidney from an AKI donor…
2021 American Transplant Congress
Attitudes of Obese Kidney Transplant Candidates Towards Bariatric Surgery
C. LaVerne, V. Thompson, G. Aguiluz, P. DiCocco, J. Almario Alvarez, M. Spaggiari, I. Tang, I. Tzvetanov, E. Benedetti
Surgery, University of Illinois Hospital & Health Sciences System, Chicago, IL
*Purpose: Obesity is an epidemic in the US and increasingly prevalent in kidney transplant candidates. Surgical weight-loss interventions are effective and reduce transplant-related complications. They…
2021 American Transplant Congress
Screening, Management and Acceptance of Patients with Aortoiliac Vascular Disease for Kidney Transplantation: An International Survey Among Transplant Surgeons
E. Rijkse¹, H. J. Kimenai¹, F. J. Dor², J. N. IJzermans³, R. C. Minnee¹
¹HPB/Transplant Surgery, Erasmus Medical Center, Rotterdam, Netherlands, ²Imperial College Transplant Centre, Hammersmith Hospital, London, United Kingdom, ³HPB/Transplant surgery, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: Aortoiliac vascular disease (AVD) is frequently observed during the work-up for kidney transplantation, but recommendations on its screening and management are lacking. We aimed…