Articles tagged "Kidney transplantation"

2021 American Transplant Congress
SARS-CoV-2 Antibody Response After Induction Therapy in Kidney Transplant Recipients
M. Lubetzky¹, S. Sultan², Z. Zhao³, M. Cushing³, Z. Kapur¹, S. Albakry¹, N. Hauser¹, J. Marku-Podvorica¹, R. Craig-Schapiro², J. Lee¹, T. Salinas¹, M. Aull², S. Kapur², M. Suthanthiran¹, D. Dadhania¹
¹Nephrology, Weill Cornell-NYPresbyterian, New York, NY, ²Transplant Surgery, Weill Cornell-NYPresbyterian, New York, NY, ³Pathology, Weill Cornell-NYPresbyterian, New York, NY
*Purpose: SARS-CoV-2 antibody prevalence in kidney transplant recipients is beginning to be reported, although little is known about the humoral immune response in the immediate…
2021 American Transplant Congress
Characterizing the Early Impact of the Kidney Accelerated Placement Project on Hard-to-place Kidneys
J. D. Motter, A. Kernodle, M. Levan, D. Segev, J. Garonzik-Wang, A. Massie
Johns Hopkins University, Baltimore, MD
*Purpose: In 2019, the OPTN implemented the Kidney Accelerated Placement Project (KAPP) in an effort to increase the utilization of kidneys with a high Kidney…
2021 American Transplant Congress
How Long is the Wait Worthwhile: Cost-Effectiveness of Accepting a Kidney from a Donor with Apolipoprotein L1 High-Risk Genotype
K. Lentine¹, D. Brennan², M. Wang³, M. Schnitzler⁴, H. Xiao⁴, D. Axelrod⁵, J. Snyder⁶, K. Lentine⁴
¹Saint Louis University, St. Louis, MO, ²Johns Hopkins, Baltimore, MD, ³Washington Univ, Saint Louis, MO, ⁴Saint Louis Univ, Saint Louis, MO, ⁵Univ of Iowa, Iowa City, IA, ⁶SRTR, Minneapolis, MN
*Purpose: The Apolipoprotein L1 (APOL1) Long-Term Outcomes (APOLLO) study is underway to define the impact of kidney donor renal risk variants (RRVs) on the survival…
2021 American Transplant Congress
The Effect of Delayed Graft Function on Early versus Late Mortality Following Kidney Transplantation
W. Irish¹, Y. Fu², D. B. Leeser¹, K. V. Ravindra³, C. Haisch¹, J. Tuttle¹
¹Surgery, East Carolina University, Greenville, NC, ²Mathematics, East Carolina University, Greenville, NC, ³Surgery, Duke University, Durham, NC
*Purpose: Delayed graft function (DGF) is associated with increased risk of long-term graft survival but it’s impact on patient survival has not been studied. Using…
2021 American Transplant Congress
Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, T. Alhamad⁵, V. Bowers⁶, I. Moinuddin⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹, G. Gupta⁷
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷Virginia Commonwealth University, Richmond, VA, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
2021 American Transplant Congress
Conversion to Belatacept Based Immunosuppression Regimen in Kidney Transplant Patients: Lessons Learned
R. Saidi, N. Huang, C. Yang, I. Movileanu, K. Ecal, A. Senay, O. Pankewycz, R. Dvorai, R. Shahbazov, M. Laftavi
SUNY Upstate, Syracuse, NY
*Purpose: The costimulatory inhibitor, belatacept (Bela) has been shown to be an effective alternative in several clinical situations including calcineurin toxicity, de novo alloantibody formation…
2021 American Transplant Congress
A Machine Learning-Based Predictive Model for Outcome of Covid-19 in Kidney Transplant Recipients
I. Revuelta¹, F. Santos-Arteaga², D. Di Caprio³, E. Montagud-Marrahi¹, F. Cofan¹, J. Torregrosa¹, M. Bodro⁴, A. Moreno⁴, P. Ventura-Aguiar¹, D. Cucchiari¹, N. Esforzado¹, G. Piñeiro¹, J. Ugalde-Altamirano¹, J. Campistol¹, A. Alcaraz⁵, B. Bayès¹, E. Poch¹, F. Oppenheimer¹, F. Diekmann¹
¹Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, ²Faculty of Economics and Management, Free University of Bolzano, Bolzano, Italy, ³Department of Economics and Management, University of Trento, Trento, Italy, ⁴Department of Infectious Diseases, Hospital Clinic, Barcelona, Spain, ⁵Department of Urology, Hospital Clinic, Barcelona, Spain
*Purpose: Health systems need tools to deal with COVID-19, especially for high-risk population,such as transplant recipients. Predictive models are necessary to improve management of patients…
2021 American Transplant Congress
Impact of Allosensitization on Xenotransplantation
D. Olaso¹, M. Manook¹, J. Yoon¹, Y. Bae¹, A. Barbas¹, A. Adams², S. Knechtle¹, J. Kwun¹
¹Department of Surgery, Duke Transplantation Center, Durham, NC, ²Department of Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…
2021 American Transplant Congress
Complement Blockade Improves Renal Xenograft Survival in Primates in the Absence of Transgenic Complement Regulatory Proteins
D. A. Faber¹, B. Lovasik¹, A. Matar¹, C. Breeden¹, A. B. Farris², M. Tector³, A. Tector³, A. Adams⁴
¹Surgery, Emory University School of Medicine, Atlanta, GA, ²Pathology, Emory University School of Medicine, Atlanta, GA, ³Surgery, University of Miami, Miami, FL, ⁴Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Complement activation is a major contributor to xenograft rejection. To minimize xenograft injury, complement suppression via insertion of human complement-regulatory transgenes into the donor…
2021 American Transplant Congress
Murine Cytomegalovirus Induces Kidney Allograft Injury via Th17 Cells Recruited by Both Viral Antigen-Specific and Cytokine/chemokine Mediated Pathways
R. Dhital¹, V. Velazquez¹, Q. Zeng², B. Graber¹, K. Flint¹, M. Shimamura¹
¹Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, ²Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH
*Purpose: Cytomegalovirus infection in transplant recipients has been associated with renal allograft rejection and graft failure. We have previously shown that murine CMV (MCMV) infected…