Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Early Outcome of Heart-Kidney Transplantation in the Current Heart Allocation System in the United States
S. Rao¹, A. Doyle¹, D. Brennan², S. Constantinescu³
¹University of Virginia, Charlottesville, VA, ²Johns Hopkins Medical Institute, Baltimore, MD, ³Lewis Katz School of Medicine at Temple University, Philadelphia, PA
*Purpose: In the United States, heart allograft allocation is a primary determinant for heart-kidney transplantation (HKT). We analyzed the OPTN dataset and compared the outcomes…
2021 American Transplant Congress
Kidney Transplant Rejection Can Be Diagnosed or Even Predicted by Tracking Donor Reactive T Cell Clones in Post-transplant Samples
Y. Sambandam¹, M. Kandpal¹, J. He¹, X. Huang¹, T. S. Taylor¹, A. A. Shetty², J. M. Mathew¹, J. R. Leventhal¹
¹Surgery-Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine, Nephrology Division, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: To test if kidney transplant (KTx) rejection can be diagnosed by monitoring for donor reactive T-cell (DRTC) clones in post-transplant (post-tx) biopsy and non-invasively…
2021 American Transplant Congress
Obesity is Associated with Greater Gender Disparity in Access to Kidney Transplantation
S. S. Sheikh, B. Orandi, P. MacLennan, H. Qu, R. M. Cannon, D. Anderson, M. Hanaway, S. Mehta, V. Kumar, R. Reed, J. Locke
Surgery, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Obesity and female gender have been associated with decreased access to kidney transplant. We sought to use contemporary data to examine the likelihood of…
2021 American Transplant Congress
High Donor-Derived Cell-Free DNA Levels Predict Development of De Novo HLA Donor-Specific Antibodies After Kidney Transplantation – Data from the ADMIRAL Study
G. Gupta¹, T. Alhamad², V. Bowers³, I. Moinuddin¹, S. Ghosh⁴, J. Zeng⁴, E. Stites⁵, A. Pai⁶, J. S. Bromberg⁷, S. Anand⁸
¹Virginia Commonwealth University, Richmond, VA, ²Washington University in St. Louis, St. Louis, MO, ³Tampa General Hospital, Tampa, FL, ⁴CareDx, Brisbane, CA, ⁵University of Colorado, Aurora, CO, ⁶University of Texas McGovern Medical School, Houston, TX, ⁷University of Maryland School of Medicine, Baltimore, MD, ⁸Intermountain Medical Center, Murray, UT
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) as a marker of injury can serve to quantify subclinical inflammation and molecular injury. As the release of graft genomic…
2021 American Transplant Congress
Cost-Effectiveness Analysis of Short-Duration Anti-Viral Prophylaxis for Hepatitis C Positive Donor Kidney Transplants
I. Yakubu, Y. Zhang, S. Ijioma, N. V. Carroll, J. Patterson, R. Sterling, G. Gupta
Virginia Commonwealth University Health System, Richmond, VA
*Purpose: Trials describing 4-12 week courses of direct-acting anti-viral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant…
2021 American Transplant Congress
High Interest, Low Payoff: Understanding Opportunities for Intervention for Those Exploring but Not Pursuing Paired Kidney Donation
A. D. Waterman¹, E. H. Wood¹, A. Thomas²
¹UCLA David Geffen School of Medicine, Los Angeles, CA, ²Johns Hopkins, Baltimore, MD
*Purpose: In 2016, the National Kidney Registry (NKR) established an online donor screening portal (DASH) to manage and track individuals interested in kidney paired donation…
2021 American Transplant Congress
Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-mediated Rejection
S. Clotet-Freixas¹, M. Kotlyar², C. M. McEvoy¹, C. Pastrello², S. Rodríguez-Ramírez¹, S. Farkona¹, H. Cardinal³, M. Dieudé³, M. Hébert³, Y. Li¹, O. Famure¹, P. Chen¹, S. Kim¹, E. Chan⁴, I. Jurisica², R. John¹, A. Chruscinski¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ⁴Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) causes >50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also…
2021 American Transplant Congress
Cardiac Outcomes in Isolated Heart and Simultaneous Kidney and Heart Transplants in the US
K. A. Agarwal¹, H. Patel¹, N. Agrawal¹, F. Cardarelli¹, N. Goyal²
¹Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, ²Nephrology, Tufts Medical Center, Boston, MA
*Purpose: Kidney dysfunction is not uncommon in patients with advanced heart failure. Simultaneous kidney and heart transplants (SKHT) have gained acceptance as treatment for patients…
2021 American Transplant Congress
The Role of the B2 Microglobulin Trend in Patients with Delayed Graft Function After Kidney Transplant
A. Perez-Gutierrez, P. J. Bachul, B. Juengel, P. Witkowski, D. DiSabato, R. Barth, J. Fung, Y. Becker
Surgery, University of Chicago, Chicago, IL
*Purpose: Delayed graft function (DGF) is associated with worse short and long-term outcomes after kidney transplantation. There is a lack of biomarkers to predict outcomes…
2021 American Transplant Congress
The Lived Experience of Older Adult Kidney Transplant Recipients: Reflections on Embodied Selfhood in Later Life
L. Kimberly
New York University Langone Health, New York, NY
*Purpose: Although the number of older adults who might benefit from kidney transplantation continues to increase in the United states, little is known about older…