Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, T. Alhamad⁵, V. Bowers⁶, I. Moinuddin⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹, G. Gupta⁷
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷Virginia Commonwealth University, Richmond, VA, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
2021 American Transplant Congress
Conversion to Belatacept Based Immunosuppression Regimen in Kidney Transplant Patients: Lessons Learned
R. Saidi, N. Huang, C. Yang, I. Movileanu, K. Ecal, A. Senay, O. Pankewycz, R. Dvorai, R. Shahbazov, M. Laftavi
SUNY Upstate, Syracuse, NY
*Purpose: The costimulatory inhibitor, belatacept (Bela) has been shown to be an effective alternative in several clinical situations including calcineurin toxicity, de novo alloantibody formation…
2021 American Transplant Congress
A Machine Learning-Based Predictive Model for Outcome of Covid-19 in Kidney Transplant Recipients
I. Revuelta¹, F. Santos-Arteaga², D. Di Caprio³, E. Montagud-Marrahi¹, F. Cofan¹, J. Torregrosa¹, M. Bodro⁴, A. Moreno⁴, P. Ventura-Aguiar¹, D. Cucchiari¹, N. Esforzado¹, G. Piñeiro¹, J. Ugalde-Altamirano¹, J. Campistol¹, A. Alcaraz⁵, B. Bayès¹, E. Poch¹, F. Oppenheimer¹, F. Diekmann¹
¹Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, ²Faculty of Economics and Management, Free University of Bolzano, Bolzano, Italy, ³Department of Economics and Management, University of Trento, Trento, Italy, ⁴Department of Infectious Diseases, Hospital Clinic, Barcelona, Spain, ⁵Department of Urology, Hospital Clinic, Barcelona, Spain
*Purpose: Health systems need tools to deal with COVID-19, especially for high-risk population,such as transplant recipients. Predictive models are necessary to improve management of patients…
2021 American Transplant Congress
Impact of Allosensitization on Xenotransplantation
D. Olaso¹, M. Manook¹, J. Yoon¹, Y. Bae¹, A. Barbas¹, A. Adams², S. Knechtle¹, J. Kwun¹
¹Department of Surgery, Duke Transplantation Center, Durham, NC, ²Department of Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…
2021 American Transplant Congress
Complement Blockade Improves Renal Xenograft Survival in Primates in the Absence of Transgenic Complement Regulatory Proteins
D. A. Faber¹, B. Lovasik¹, A. Matar¹, C. Breeden¹, A. B. Farris², M. Tector³, A. Tector³, A. Adams⁴
¹Surgery, Emory University School of Medicine, Atlanta, GA, ²Pathology, Emory University School of Medicine, Atlanta, GA, ³Surgery, University of Miami, Miami, FL, ⁴Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Complement activation is a major contributor to xenograft rejection. To minimize xenograft injury, complement suppression via insertion of human complement-regulatory transgenes into the donor…
2021 American Transplant Congress
Murine Cytomegalovirus Induces Kidney Allograft Injury via Th17 Cells Recruited by Both Viral Antigen-Specific and Cytokine/chemokine Mediated Pathways
R. Dhital¹, V. Velazquez¹, Q. Zeng², B. Graber¹, K. Flint¹, M. Shimamura¹
¹Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, ²Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH
*Purpose: Cytomegalovirus infection in transplant recipients has been associated with renal allograft rejection and graft failure. We have previously shown that murine CMV (MCMV) infected…
2021 American Transplant Congress
Augmented Responses of Donor Kidney Tubular Cells to TLR Signaling Correlate with Ameliorated Ischemia/reperfusion Injury and Long-term Allograft Protection
X. Lai¹, J. Wang¹, L. Qiu², S. Han¹, K. Shen¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University, Chicago, IL, ²University of California, San Francisco, San Francisco, CA
*Purpose: We have previously demonstrated that donor genetic background and kidney-intrinsic innate immunity were key determinants of delayed graft function in kidney transplantation. However, the…
2021 American Transplant Congress
Blood Gene Expression and Donor-derived Cell Free DNA for Diagnosing Subclinical Acute Rejection in Stable Kidney Transplant Recipients
S. Park¹, K. Guo², H. Raymond³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁸, J. Holman⁹, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹⁰, J. Friedewald¹
¹Transplant Nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Transplant Genomics, Inc, Mansfield, MA, ¹⁰University of Arizona College of Medicine, Tucson, AZ
*Purpose: A blood gene expression profile (GEP) has been established as a non-invasive screen for subclinical acute rejection (subAR). For patients with allograft dysfunction, donor-derived…
2021 American Transplant Congress
Cellular and Genetic Signatures of Operational Tolerance in Kidney Transplant Recipients Through Single Cell R N A Sequencing Analysis
H. BAE¹, H. Lee², J. Ryu³, B. Chung², E. Oh³
¹Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, ²Department of Internal Medicine, Division of Nephrology, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, Seoul, Korea, Republic of, ³Department of Laboratory Medicine, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of
*Purpose: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results. We analyzed differently expressed mRNAs and proteins…
2021 American Transplant Congress
Relationship Between Tacrolimus Blood Levels and Covid-19 Pandemic in Kidney Transplant Recipients
T. Inoue¹, K. Unagami,², A. Ishiwatari³, T. Kanzawa³, T. Shimizu³, K. Omoto³, M. Inui³, T. Suzuki¹, H. Ishida⁴, K. Tanabe³
¹Department of Nephrology, Kameda Medical Center, Chiba Kamogawa, Japan, ²Department of Organ Transplant Medicine, Tokyo Women’s Medical University, Tokyo, Japan, ³Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Department of Organ transplant medicine, Tokyo Women’s Medical University, Tokyo, Japan
*Purpose: The novel coronavirus 2019 infection (COVID-19) caused a pandemic, prompting Tokyo, Japan, to restrict on the free movement of people in March 2020. Kidney…