Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Iguratimod Alleviates Endothelial to Mesenchymal Transition by Inducing AMBRA1/PARKIN-Dependent Mitophagy and Inhibiting NLRP3 Activation During Renal Allograft Interstitial Fibrosis
Z. Gui¹, W. Zijie², M. Zheng³, R. Tan³, M. Gu⁴
¹Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²Jiangsu Province Hospital, Nanjing, China, ³Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China, ⁴Department of Urology, the Second Affiliated Hospital with Nanjing Medical University, Nanjing, China
*Purpose: Chronic renal graft dysfunction (CAD) is caused by multiple factors, including glomerular sclerosis, inflammation, interstitial fibrosis and tubular atrophy (IF/TA). However, the most prominent…
2022 American Transplant Congress
Delayed Graft Function in Kidney Transplant Recipients is Associated with an Increased Risk f Post-Transplant Infections
V. Manchala, B. Muth, E. Yousif, J. Turk, J. Blazel, M. Bloom, N. Garg, F. Aziz, M. Mohamed, A. Djamali, D. Mandelbrot, B. Astor, S. Parajuli
UWSMPH, Madison, WI
*Purpose: Delayed graft function (DGF) is a known complication among kidney transplant recipients (KTRs) and is associated with decreased graft survival, increased rejection, and increased…
2022 American Transplant Congress
RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy
W. Yicun, W. Yuxuan, H. Xiaopeng
Department of Urology, Beijing Chaoyang Hospital, Beijing, China
*Purpose: BK virus-associated nephropathy (BKVN) remains a major infectious complication of kidney transplantation, and its histologic appearance can mimic rejection, leading to a diagnostic dilemma…
2022 American Transplant Congress
Glomerular Filtration Rates (GFR) Reference Values for Living Kidney Donors Using the 2021 CKD-EPI Equation without the Race Factor
A. Liaqat, L. Cholin, H. Sawaf, S. Arrigain, J. Augustine, J. Schold, E. Poggio
Cleveland Clinic, Cleveland, OH
*Purpose: Kidney function is central to donor evaluation and KDIGO guidelines recommend using estimated GFR (eGFR) for initial screening. A new creatinine-based CKD-EPI equation ('21…
2022 American Transplant Congress
Differential Impact of Subclinical Kidney Transplant Rejection in Young Adults
S. Raza¹, G. Agarwal¹, H. Fatima¹, R. Gaston¹, V. Hauptfeld-Dolesjek¹, B. Julian¹, C. Kew¹, V. Kumar¹, S. Mehta¹, S. Ong¹, F. Rosenblum¹, G. Towns¹, R. Mannon², M. Seifert¹
¹School of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²College of Medicine, University of Nebraska, Omaha, NE
*Purpose: Serum creatinine, while an insensitive biomarker of allograft injury, is the current standard for assessing the stability of allograft function and guiding kidney transplant…
2022 American Transplant Congress
Elevated Donor-Derived Cell-Free DNA (dd-cfDNA) in the Early Post-Transplant Period is Associated with an Increased Incidence of Adverse Clinical Outcomes in Kidney Transplant Recipients
D. Wojciechowski¹, A. Patel², S. Anand³, J. Klein⁴, A. Paramesh⁵, P. Sood⁶, G. Shekhtman⁷, N. Agrawal⁷, M. Fei⁷, K. Qu⁷, D. C. Brennan⁸
¹University of Texas, Southwestern, Dallas, TX, ²Saint Barnabas Medical Center, Livingston, NJ, ³Intermountain Healthcare, Murray, UT, ⁴University of Kansas Medical Center, Kansas City, KS, ⁵Tulane University School of Medicine, New Orleans, LA, ⁶University of Pittsburgh Medical Center, Pittsburgh, PA, ⁷CareDx, Brisbane, CA, ⁸Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Early post-transplant elevations in dd-cfDNA, even in the absence of histologic rejection or other overt pathology, have been suggested to carry a risk of…
2021 American Transplant Congress
Systematic Screening of Kidney Transplant Patients Points Towards Deficits in Neutralizing Antibody Capacity Against Sars-cov-2
V. Wijtvliet¹, K. K. Ariën², J. Mariën², B. Peeters³, R. Hellemans⁴, A. Massart⁴, S. Van Hees¹, P. Moons⁵, H. Theeten⁶, P. Van Damme⁶, H. Goossens⁷, B. Y. De Winter¹, K. J. Ledeganck¹, D. Abramowicz⁴
¹Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium, ²Department of Biomedical Sciences, Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium, ³Department of Laboratory Medicine, Antwerp University Hospital, Antwerp, Belgium, ⁴Department of Nephrology and Hypertension, Antwerp University Hospital, Antwerp, Belgium, ⁵Biobank, Antwerp University Hospital, Antwerp, Belgium, ⁶Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium, ⁷Department of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
*Purpose: The majority of kidney transplant recipients (KTR) is able to develop SARS-CoV-2 antibodies (Abs). Little is known about the virus neutralizing capacity of these…
2021 American Transplant Congress
Outcomes of Kidney Transplantation in Patients with Prosthetic Heart Valves
H. Ouahmi
Nephrology, Dialysis, Transplantation, Nice University Hospital, Nice, France
*Purpose: Due to the aging of the population, a growing number of patients with end-stage kidney disease (ESKD) require cardiac valve replacement. As a consequence,…
2021 American Transplant Congress
Mortality, Risk Factors, and Treatment of Covid-19 Infection in Solid Organ Transplants: A Systematic Review and Meta-analysis
S. Yin, T. Song, Q. Zhong, T. Lin
Urology Institute and Organ Transplantation Center, West China Hospital, Chengdu, China
*Purpose: Outcomes for solid organ transplants (SOT) with COVID-19 have not been summarized, and prognostic factors for COVID-19 in SOT patients are not well established…
2021 American Transplant Congress
Impact of High-Risk EBV Discordance Status on Survival Outcomes in Kidney Transplant Recipients: A Multivariable Analysis
A. Dinesh¹, S. Jackson², T. L. Pruett¹, S. Riad³
¹Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, ²Biostatistics, Analytics Consulting Services- Solid Organ Transplant, M Health Fairview, Minneapolis, MN, ³Department of Medicine, University of Minnesota, Minneapolis, MN
*Purpose: High-risk EBV discordance has been linked to Post-Transplant Lymphoproliferative Disorder (PTLD) after kidney transplantation; however, the impact on recipient and graft survival is under-reported.…