Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts
X. Lai¹, J. Wang¹, S. Han¹, C. Chunlei¹, L. VanOsdol¹, L. Gallon², J. Leventhal², M. Kandpal¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
2022 American Transplant Congress
Kidney Nonprocurement in Deceased Donors with Acute Kidney Injury
K. Yu¹, K. King¹, S. Husain¹, J. Stevens¹, C. Parikh², S. Mohan¹
¹Division of Nephrology, Columbia University Medical Center, New York, NY, ²Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Deceased donor acute kidney injury (AKI) is associated with high rates of kidney discard by transplant centers, despite evidence of excellent post-transplant outcomes. High…
2022 American Transplant Congress
Differences in Medication Adherence Between Preemptive and Post-Dialysis Young Kidney Transplant Recipients
Y. Vaisbourd¹, E. Samson², A. De Simone², M. Dahhou², B. Foster³
¹Pediatrics, McGill University, Montréal, QC, Canada, ²McGill University, Montréal, QC, Canada, ³Montreal Children's Hospital, Montreal, QC, Canada
*Purpose: The mechanisms underlying the superior graft survival associated with pre-emptive kidney transplantation, compared with transplantation following a period of dialysis, are unknown. Selection for…
2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Cell Profile in Kidney Allografts with Recurrent Focal Segmental Glomerular Sclerosis (FSGS)
L. Gallon¹, E. Bardhi², J. McDaniels², A. Shetty², P. Hallack¹, C. Kuscu³, C. Kuscu³, T. Rousselle², J. Eason³, D. Maluf², V. Mas²
¹NWU, Chicago, IL, ²University of Maryland, Baltimore, MD, ³UTHSC, Memphis, TN
*Purpose: Strong evidence suggests that primary FSGS is due to a plasma factor that results in general podocyte dysfunction and risk of recurrence after kidney…
2022 American Transplant Congress
Kidney Transplantation Utilizing SARS-CoV-2 Rt-PCR Positive Donor Kidneys with Immediate Post Exposure Casirivimab /Imdevimab Followed by Thymoglobulin Induction
S. K. Patel¹, E. Siskind¹, M. Laftavi¹, J. Splinter¹, E. Shipman², S. Shah¹, S. Nijim¹, A. Adekile¹, S. Asad¹
¹Center for Transplantation, University Medical Center of Southern Nevada, Las Vegas, NV, ²Nevada Donor Network, Las Vegas, NV
*Purpose: At the beginning of the pandemic, kidneys from SARS-CoV-2 (COVID) RT-PCR positive donors were not utilized for transplantation, due to the risk of viral…
2022 American Transplant Congress
Alloreactive Human Regulatory T Cell-Derived Extracellular Vesicles Exhibit Adenosinergic Mediated Suppression and Potential for Infectious Tolerance
B. Schreiber, S. Tripathi, A. Chandraker
Brigham and Women's Hospital, Boston, MA
*Purpose: Regulatory T cells (Tregs) suppress the immune response through both contact dependent and independent mechanisms. Extracellular vesicles (EVs) are emerging as novel contact independent…
2022 American Transplant Congress
Cortex Recipient Weight Ratio is a Predictor for Short-Term Renal Function After Living Donor Kidney Transplant
K. Takahashi¹, K. Furuya¹, J. Usui², T. Kimura³, S. Fukuda⁴, A. Hoshi³, T. Yoshino³, H. Nishiyama³, T. Oda¹, K. Yamagata²
¹Gastrointestinal and Hepatobiliary Pancreatic Surgery, University of Tsukuba, Tsukuba, Japan, ²Nephrology, University of Tsukuba, Tsukuba, Japan, ³Urology, University of Tsukuba, Tsukuba, Japan, ⁴Nursing, University of Tsukuba, Tsukuba, Japan
*Purpose: Renal function early after living donor kidney transplant (LDKT) depends on “nephron mass” in the renal graft, and “nephron mass” can be quantified as…
2022 American Transplant Congress
Impact of Donor-Recipient Age Discrepancy in Living Donor Kidney Transplantation – The Need for Better Matching
N. K. Prabhu¹, V. Villani¹, K. P. Samy¹, D. Sudan¹, K. Ravindra¹, W. Irish²
¹Surgery, Duke University Medical Center, Durham, NC, ²Surgery, East Carolina University, Greenville, NC
*Purpose: The Kidney Allocation System (KAS) was implemented in 2014 to address donor-recipient matching in deceased donor kidney transplantation, with the goal of maximizing life-years…
2022 American Transplant Congress
Viral-Specific Cytotoxic T-Cell Responses in Hla-Sensitized Kidney Transplant Patients Maintained on Everolimus and Low Dose Tacrolimus
R. Zhang¹, S. Ge¹, M. Chu¹, J. Kahwaji², A. Karasyov¹, D. Lovato¹, A. Vo², J. Choi², M. Toyoda¹, S. Jordan²
¹Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Post-transplant immunosuppression with “everolimus + reduced dose tacrolimus” (Ev + Taclow) is reported to reduce the risk of viral infections compared to standard doses…
2022 American Transplant Congress
Center Volume and Transplant Outcomes in Adult Kidney Transplant Recipients; A Competing Risk Analysis
A. Azhar¹, E. Defor¹, L. Kamal¹, D. Bandyopadhyay¹, B. Tanriover², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²University of Arizona, Tuscon, AZ
*Purpose: The precise effect of center volume is a much-debated topic in the field of transplantation. Several studies have shown better post-transplant outcomes in higher…