ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Kidney transplantation"

  • 2015 American Transplant Congress

    Low Vitamin D Exposure Is Associated With Higher Risk of Infection in Renal Transplant Recipients

    L. Sacha,1 H. Kalluri,2 A. Ingemi,3 H. Johnson,4 D. Landsittel,5 M. Shullo,4 R. Venkataramanan.2,6

    1Department of Pharmacy, Saint Barnabas Medical Center, Livingston, NJ; 2Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA; 3Department of Pharmacy, Sentara Norfolk General Hospital, Norfolk, VA; 4Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA; 5Department of Medicine, University of Pittsburgh, Pittsburgh, PA; 6Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA.

    PURPOSE: Vitamin D has multiple vital functions within the immune system. This study aims to assess the relationship between vitamin D exposure and the incidence…
  • 2015 American Transplant Congress

    Calcineurin (CNI) Exposure Reduces the Risk of Post-Transplant DSA After Deceased Donor Kidney Transplantation

    R. Pelletier, A. Rajab, G. Bumgardner, M. Henry.

    General Surgery, The Ohio State University, Columbus, OH.

    We use ATG induction with immediate rapamune (Rapa) and delayed CNI immunosuppression following kidney transplantation. Mycophenolic acid (MPA) is substituted for CNI to avoid renal…
  • 2015 American Transplant Congress

    The Impact of Cytokine Release Caused By Induction Immunosupression On Nitric Oxide in Renal transplantation

    R. Johns,1,2 M. Laftsidis,2 E. Burrows,2 F. Edwards,2 E. Ablorsu,2 P. James,1 A. Phillips,1,2 A. Asderakis.2

    1University of Cardiff, Cardiff, United Kingdom; 2University Hospital of Wales, Cardiff, United Kingdom.

    IntroductionVarying induction immunosuppression regimens have a differential impact on the pattern of cytokine release. Pro-inflammatory cytokines stimulate endothelial cells causing secretion of NO. Serum nitrite…
  • 2015 American Transplant Congress

    "What's the Mileage?" Determining the Length of Time in Which Renal Function Returns to Pre-Calcineurin Discontinuation Levels in Patients With Interstitial Fibrosis

    A. Diez, J. Von Visger, U. Nori, T. Pesavento, M. Henry, E. Davies, R. Pelletier.

    The Ohio State University, Columbus.

    Calcineurin Inhibitors (CNI) use may be associated with progressive renal dysfunction. Clinical trials have shown that CNI minimization or discontinuation may aid in improvement in…
  • 2015 American Transplant Congress

    Intra-Lymphocyte Concentrations of Mycophenolic Acid Correlate With the Incidence of Early Graft Rejection in Renal Transplant Recipients

    Z. Md Dom,2 J. Coller,2 R. Carroll,3 A. Somogyi,2 B. Sallustio.1

    1Clinical Pharmacology, The Queen Elizabeth Hospital, Adelaide, Australia; 2Discipline of Pharmacology, Univeristy of Adelaide, Adelaide, Australia; 3Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia.

    Introduction: Although routine therapeutic drug monitoring of mycophenolic acid (MPA) concentrations in plasma has been recommended to individualize MPA doses in transplant recipients, little is…
  • 2015 American Transplant Congress

    Arterial Hypertension and the Use of Antihypertensive Medication in Pediatric Renal Transplant Patients: An Analysis of the CERTAIN Registry

    R. Sugianto,1 E. Wühl,2 B. Schmidt,1 S. Geyer,3 K. Krupka,2 B. Höcker,2 B. Tönshoff,2 A. Melk.1

    1Department of Pediatric Nephrology, Hannover Medical School, Hanover, Germany; 2Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany; 3Department of Medical Sociology, Hannover Medical School, Hanover, Germany.

    BackgroundOur study aimed to describe the prevalence of hypertension, blood pressure (BP) control and the use of antihypertensive (AH) drugs in pediatric renal transplant patients.MethodsCasual…
  • 2015 American Transplant Congress

    Low Dose Valganciclovir Prophylaxis Following Renal Transplantation With Steroid Free Immunosuppression

    J. Chen,1 A. Shah,2 M. Sauer,1 T. Taber,3 A. Sharfuddin,3 M. Yaqub,3 D. Mishler,3 J. Powelson,4 W. Goggins.4

    1Pharmacy, IU Health, Indianapolis; 2Surgery, Thomas Jefferson University, Philadelphia; 3Nephrology, Indiana University School of Medicine, Indianapolis; 4Surgery, Indiana University School of Medicine, Indianapolis.

    AST ID guidelines recommend a valganciclovir (VGCV) prophylaxis dose of 900 mg daily for patients with CrCL > 60 mL/min with reduced dose for renal…
  • 2015 American Transplant Congress

    Does a History of Diabetes in Deceased Donors Modify the Outcomes of Kidney Transplant Recipients With Diabetes?

    T. Rajan, J. Kim.

    Division of Nephrology and the Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada.

    Background: The outcomes of kidneys from deceased donors with diabetes mellitus (dDM+) transplanted into recipients with DM (rDM+) have not been well studied.Methods: A cohort…
  • 2015 American Transplant Congress

    De Novo DSA Would Not Necessarily Cause Graft Rejection After Renal Transplantation: Characteristics of DSA Developing Biopsy-Proven Chronic Antibody-Mediated Rejection

    T. Yamamoto, Y. Watarai, A. Takeda, M. Okada, M. Tsujita, H. Takahisa, N. Goto, S. Narumi, T. Kobayashi.

    Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan.

    Introduction:De novo donor-specific HLA antibodies (dn DSA) production after renal transplantation has been reported to be associated with chronic antibody mediated rejection (CAMR), which leads…
  • 2015 American Transplant Congress

    Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure

    J. Lan, D. Gjertson, Y. Zheng, DeKAF Investigators, E. Reed, M. Cecka.

    Path, UCLA, LA, CA.

    Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…
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