2015 American Transplant Congress
Selective Blockade of the CD28/B7/CTLA4 Pathway With Monovalent Anti-CD28 Antibodies Versus Targeting of B7 With CTLA4-Ig, in Non-Human Primate Kidney Allograft
1INSERM, UMR1064, ITUN, Nantes, France; 2Effimune SAS, Nantes, France.
B7 molecules on antigen-presenting cells interact with CD28 and CTLA4 on T lymphocytes to control TCR-mediated signals. Whereas it is highly efficient to block T…2015 American Transplant Congress
Glucose Chemical Exchange Saturation Transfer MRI of Acute Renal Allograft Rejection
Purpose: During acute rejection episodes large amounts of immune cells infiltrate renal grafts, leading to inflammation accompanied by an increased glucose metabolism.Given these circumstances we…2015 American Transplant Congress
hTERT, BICD1 and Chromosome 18 Polymorphisms Affecting Telomere Length Are Associated With Kidney Transplantation Outcome
Telomere length (TL) has been analyzed in regard to cell senescence and ageing of animals and humans, including age-related diseases. There have been also attempts…2015 American Transplant Congress
Low Dose Valganciclovir Is an Effective Prophylaxis Against Cytomegalovirus in High Risk (Donor+/ Recipient-) Kidney Transplants Recipients
Introduction: Universal prophylaxis against Cytomegalovirus (CMV) disease is endorsed in high risk seronegative kidney (K) transplant (TX) recipients of organs from seropositive donors (D+/R-) using…2015 American Transplant Congress
Kidney Transplantation (KTx) With Positive Crossmatch (XM) but No Donor Specific Antibody (DSA)
MedStar Georgetown Transplant Institute, Washington, DC.
Purpose: Prior to KTx, a XM is performed between the intended recipient and donor. This XM can be positive despite no DSA. It can be…2015 American Transplant Congress
Outcomes in Kidney Transplant Recipients Over Age of 55 by Donor Source: LD, SCD, ECD
University of Minnesota, Mpls.
Background: Outcomes in older kidney transplant recipients from SCD and ECD have been studied; however, comparative outcomes between older recipients of LD, SCD and ECD…2015 American Transplant Congress
Predictive Value of Cardiovascular Risk Assessment Tools in Kidney Transplantation
Surgery, Albert Einstein College of Medicine, Bronx, NY.
Cardiovascular disease is a major cause of morbidity and mortality following kidney transplantation. Many cardiovascular risk screening tools have been developed, but they have never…2015 American Transplant Congress
Factors Influencing Cost Among Kidney, Liver, and Heart Transplant Patients in a Private Payer Setting
1Optum, Minneapolis; 2Saint Louis University, St. Louis.
The factors influencing cost in solid organ transplantation have been evaluated by many individual centers, as well as nationally for Medicare patients. However, the majority…2015 American Transplant Congress
Mesenchymal Stromal Cells (MSCs) Given Post-Transplant Together With C3a and C5a Receptor Antagonists Prevent Engraftment Syndrome and Induce a Mild Not-Significant Prolongation of Graft Survival
Bone marrow (BM)-derived MSC given the day before kidney allografts localize into lymphoid organs and induce significant prolongation of graft survival in mice. By contrast,…2015 American Transplant Congress
Mitochondrial Feedback Mechanisms in Kidney Cell Senescence
BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…
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