Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Reassessing Tubulitis and Interstitial Infiltrate: Creating a New Probabilistic Definition of TCMR
P. Halloran, I. Salazar, M. Lopez, J. Chang.
Alberta Transplant Applied Genomics Centre, Edmonton, Canada.
Conventional diagnosis of T cell-mediated rejection (TCMR) in kidney transplant biopsies relies on interstitial inflammation (i-lesions), tubulitis (t-lesions), vasculitis (v-lesions) and experience-derived interpretation rules. The…
2015 American Transplant Congress
The Effects of Dialysis Vintage and Hypertensive Renal Failure on Colonoscopy Findings During Kidney Transplant Evaluation
Y. Zheng,¹ K. Chaung,¹ P. Park,¹ J. Augustine,² N. Sarabu,² J. Schulak,² E. Sanchez,² V. Humphreville,² J. Ammori,² K. Woodside.²
¹School of Medicine, Case Western Reserve University, Cleveland, OH; ²Department of Surgery, University Hospitals Case Medical Center, Cleveland, OH.
Colonoscopy as a screening modality starting at age 50 has recently undergone scrutiny due to concerns over the risks and benefits. We sought to identify…
2015 American Transplant Congress
HLA-Cw Mismatches Are Not Associated With Worse Graft Outcomes After Kidney Transplantation Even in High Levels of Antigen Expression
M. Askar,¹ N. Elfadawy,^1,2 S. Flechner,¹ K. Abu-Elmagd,¹ J. Fung,¹ J. Schold.¹
¹Cleveland Clinic, Cleveland; ²University of Alexandria, Alexandria, Egypt.
The HLA-Cw antigens are distinct in having relatively lower expression on the cell surface compared to the other HLA class I loci. Higher HLA Cw…
2015 American Transplant Congress
No Significant Outcome Benefit for Brand-Name Versus Generic Tacrolimus in Kidney Transplant Recipients: SRTR Analysis
D. Goldfarb,¹ E. Poggio,¹ S. Flechner,¹ R. Fatica,¹ J. Schold.²
¹Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
IntroGeneric formulations of tacrolimus have been available for maintenance immunosuppression since 2009. Our aim was to evaluate the frequency of use of generic tacrolimus and…
2015 American Transplant Congress
Long-Term Efficacy and Safety of an EVR- Vs. an MMF-Based Regimen After Pediatric Kidney Transplantation (KTX): A Case-Control Study Within the CERTAIN Registry
L. Pape,¹ T. Ahlenstiel-Grunow,¹ B. Hoecker,² M. Bald,³ K. Kruppka,² B. Toenshoff,² L. Brunkhorst.¹
¹Pediatric Nephrology, Hannover Medical School, Hannover, NDS, Germany; ²Pediatric Nephrology, University Children's Hospital, Heidelberg, BW, Germany; ³Pediatric Nephrology, Olgahospital, Stuttgart, BW, Germany.
Background: Only short-term trials using everolimus (EVR) in children after KTX have been published. Hereby we present 4 year data on low-dose ciclosporin A (CsA),…
2015 American Transplant Congress
Intra-Renal Cytokine Measurement Detected During Kidney Allograft Biopsies Portend Severity of Histological Injury
N. Leca, S. Anderson, K. Muczynski.
Division of Nephrology, University of Washington, Seattle, WA.
Histological changes observed on renal allograft biopsies, although considered the current standard for evaluation of allograft injury, lack specificity and disease activity assessment. We devised…
2015 American Transplant Congress
Monitoring Intracellular Tacrolimus Concentration in Kidney Transplant Recipients With Stable Graft Function
E. Bae,¹ S. Han,¹ S. Yang,² J. Park,¹ H. Lee,¹ J. Lee,³ D. Kim,¹ Y. Kim.¹
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Kidney Research Institute, Seoul National University, Seoul, Korea; ³Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Background: Monitoring the intracellular concentration of immunosuppressive agents can be promising to improve and individualize clinical practice in patients receiving transplantation. However, this issue remains…
2015 American Transplant Congress
Dialysis Facility Kidney Transplant Referral in Georgia: 2005-2012
S. Pastan,¹ J. Gander,¹ L. Plantinga,¹ L. Sauls,² E. Gibney,³ L. Mulloy,⁴ J. Krisher,² R. Patzer.¹
¹Emory University, Atlanta; ²Southeastern Kidney Council, Raleigh, NC; ³Piedmont Hospital, Atlanta, GA; ⁴Georgia Regents University, Augusta, GA.
Purpose: Significant variation exists in Standardized Transplantation Ratios (STR) at the dialysis facility level, and GA has the lowest kidney transplant (KTx) rate in the…
2015 American Transplant Congress
Risk of Cause-Specific ESRD in Live Kidney Donors
S. Anjum, A. Muzaale, A. Massie, S. Bae, D. Segev.
Johns Hopkins, Baltimore.
The purpose of this study is to investigate the risk of developing cause-specific ESRD in live kidney donors over time.METHODS: We studied a cohort of…
2015 American Transplant Congress
Center-Level Experience and Kidney Transplant Outcomes in HIV-Infected Recipients
J. Locke,¹ R. Reed,¹ S. Mehta,¹ C. Durand,² R. Mannon,¹ P. MacLennan,¹ B. Shelton,¹ M. Martin,¹ H. Qu,¹ R. Shewchuk,¹ D. Segev.²
¹Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham; ²Comprehensive Transplant Center, Johns Hopkins Medical Institutions, Baltimore.
Background: Excellent outcomes among HIV+ kidney transplant (KT) recipients have been reported by the NIH consortium, but it is unclear if experience with HIV+ KT…