2015 American Transplant Congress
Effect of Everolimus on Cardiovascular Parameters in De Novo Kidney Transplant Recipients: 12-Month Results from the ELEVATE Study
Background: Long-term exposure to calcineurin inhibitors (CNIs) contributes to an unfavorable cardiovascular (CV) risk profile, including inferior renal allograft function and premature graft loss with…2015 American Transplant Congress
Clinical Outcome of Patients With De Novo C1q Binding Donor-Specific HLA Antibodies After Renal Transplantation
A. Not all de novo donor-specific HLA antibodies (dnDSA) are causing immediate graft loss. The importance of complement-binding DSA was recently shown with a commercial…2015 American Transplant Congress
Renal Allografts Demonstrate Improved Pathology After Belatacept Therapy
1University of Maryland School of Medicine, Baltimore; 2Johns Hopkins University, Baltimore.
Belatacept provides immunosuppression via costimulation blockade and has been associated with improved renal function compared to calcineurin inhibitor based therapies. We developed the Maryland Aggregate…2015 American Transplant Congress
A Distinct Glomerular Complement Deposition Pattern in Transplant Glomerulopathy
University of Minnesota, Minneapolis.
While many patients with transplant glomerulopathy (TG) have donor-specific antibodies, the lack of C4d deposition in the peritubular capillaries (ptc-C4d) in some cases has caused…2015 American Transplant Congress
Acute Kidney Injury in Kidney Transplant Patients According to the KDIGO Criteria
Kidney Transplantation, Albert Einstein Hospital, Sao Paulo, Brazil.
Purpose.To assess the incidence, risk factors and outcomes associated with acute kidney injury (AKI) in kidney transplant in patients using KDIGO classification. Methods- Retrospective cohort…2015 American Transplant Congress
A Comparative Analysis of Histological Scoring in Living Donor Renal Transplants from Donors Above and Below 60 Years of Age
BACKGROUND AND OBJECTIVES: World Health Organisation estimates that the absolute number of people aged 60yrs and over will increase from 605-million to 2-billion over the…2015 American Transplant Congress
Impact of Donor Age on Longterm Outcomes in Asian Kidney Transplant Recipients: A Multicenter Cohort Study
Background The living donor kidney transplantation (LDKT) is well known for best treatment of end-stage renal disease. Recently, kidney transplantation from elderly living donor has…2015 American Transplant Congress
The Association Between Donor & Recipient Gene Variants and Tacrolimus Safety & Efficacy in a Diverse Cohort of Kidney Transplant Recipients
Medical University of South Carolina, Charleston, SC.
Previous studies have associated donor P-glycoprotein (PGP) gene variants (ABCB1) with risk of developing CNI-toxicity, while also establishing recipient CYP3A5*1 and ABCB1 gene variants are…2015 American Transplant Congress
Single Cell Phospho-Protein Analysis Demonstrates That Immunosuppressive Drugs Inhibit MAPK and mTOR Signaling Molecules in Primary Monocytes After Transplantation
Nephrology and Transplantation, Dept. of Internal Medicine, Erasmus MC, Rotterdam, Netherlands.
Monocytes have been identified as key players driving rejection processes. It is therefore surprising that there are almost no data available about the impact of…2015 American Transplant Congress
Emerging Strategies to Screen Kidney Offers Based on the Kidney Donor Profile Index (KDPI)
Background: In the Organ Procurement and Transplantation Network's (OPTN) new kidney allocation system, kidney offers are screened by setting for each candidate a maximum acceptable…
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