Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Cyclophosphamide as a Salvage Therapy for Combined Intravenous Immunoglobulins and Plasmapheresis Refractory Antibody-Mediated Rejection
W. Habhab,¹ A. Dada,² M. Alwassia,¹ N. Baz,² N. Zabani,¹ A. Fahmy,¹ A. Abdul Malik.¹
¹Nephrology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; ²Pathlogy, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Acute antibody-mediated rejection (AMR) poses a significant risk to graft survival. Current or standard treatment (ST) of AMR currently consists of plasmapheresis (PP), intravenous immunoglobulin…
2015 American Transplant Congress
IL-17 Production Influenced by Induction Therapy With ATG
D. Abendroth,¹ M. Marzinzig,¹ J. Kaden.²
¹Center of Surgery, University of Ulm, Ulm, Germany; ²Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany.
Introduction Immune-mediated rejection remains the most important cause of graft failure. Recently, a newly identified CD4+ T cell subset, Th17, distinct from Th1 or Th2,…
2015 American Transplant Congress
Diabetes Mellitus and Prediabetes On Kidney Transplant Waiting List – Prevalence, Metabolic Phenotyping and Risk Stratification Approach
M. Guthoff,¹ D. Vosseler,¹ J. Langanke,¹ S. Nadalin,² A. Königsrainer,² H.-U. Häring,¹ A. Fritsche,¹ N. Heyne.¹
¹Dept. of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany; ²Dept. of General, Visceral and Transplant Surgery, University of Tübingen, Tübingen, Germany.
Purpose: Diabetes mellitus (DM), the most common cause of ESRD, limits access to transplantation and impairs patient and allograft outcome. Prediabetes is an independent risk…
2015 American Transplant Congress
Burden of Early Antibody-Mediated Rejection (AMR): Complications, Resource Utilization and Cost-Differential in Treatment of AMR
R. Banga,¹ C. Schinstock,¹ A. Boscoe,⁴ M. Hathcock,³ W. Kremers,³ M. Stegall.²
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; ³Division of Biostatistics, Mayo Clinic, Rochester, MN; ⁴Health Outcomes Research, Alexion Pharmaceuticals, Cheshire, CT.
Early antibody-mediated rejection (AMR) is common in positive crossmatch kidney transplants (+XMKTx). The current study determined the complications, resource utilization and cost associated with early,…
2015 American Transplant Congress
Is the Pulsatile Kidney Preservation Machine a Vaulable Tool in Evaluating Kidney Suitability from Older Donors After Brain Death?
D. Paredes Zapata,¹ A. Ruiz Arranz,¹ C. Rodriguez Villar,¹ L. Peri Cussi,² A. Alcaraz Asensio,² R. Adalia Bartolome,¹ F. Oppenheimer Salinas.³
¹Donation and Transplant Coordination Section, Hospital Clinic, University of Barcelona, Barcelona, Spain; ²Urology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain; ³Renal Transplant Unit, Hospital Clinic, Barcelona, Spain.
Introduction: Donors after Brain Death (DBD) older than 60 years old, have become 46.8% of our donor activity, with higher Discard Rate (DR). Assessment of…
2015 American Transplant Congress
MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ A. Perkowska Ptasińska,¹ A. Sadowska,¹ M. Nowaczyk,⁵ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.
MYH9 encoding a non-muscle myosin heavy chain IIA is expressed in podocytes, mesangial, tubular, capillary endothelial cells and vascular wall. Intronic variants of MYH9 associate…
2015 American Transplant Congress
Kidney Transplant Outcomes in Patients With Amyloidosis
J. Verbesey, M. Cooper, P. Weems, A. Gilbert, M. Grafals, C. Nilubol, J. Moore, S. Ghasemian, B. Javaid.
Kidney and Pancreas Transplant Program, MedStar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC.
Objective: Analyze kidney allograft outcomes in patients with kidney failure due to amyloidosis, and compare kidney transplant survival to patients with other causes of kidney…
2015 American Transplant Congress
Center Volume Is Associated With Early Graft Failure After Living Donor Kidney Transplantation
B. Shelton, P. MacLennan, R. Reed, D. Sonnier, M. Hanaway, J. Goodman, C. Young, M. Deierhoi, J. Locke.
Surgery/Transplantation, University of Alabama at Birmingham, Birmingham, AL.
Introduction: The correlation between center volume and outcomes has been established within general surgery and is most pronounced within the context of high-risk, low-volume procedures.…
2015 American Transplant Congress
Change in Physical Function Following Kidney Transplantation
E. Lorenz, A. Cheville, B. Kotajarvi, F. Cosio, N. LeBrasseur.
Mayo Clinic, Rochester, MN.
Introduction: Improved physical function is associated with increased survival in the general population. Little is known about whether physical function improves following kidney transplant. The…
2015 American Transplant Congress
Differentially Expressed Genes in Immunosuppressed Kidney Transplant Recipients
C. Dorr,¹ B. Wu,² W. Guan,² A. Muthusamy,¹ K. Sanghavi,³ P. Jacobson,³ W. Oetting,³ D. Schladt,¹ R. Remmel,³ J. Maltzman,⁵ A. Matas,⁴ For DeKAF Genomics Investigators,¹ A. Israni.¹
¹Medicine, MMRF, HCMC, Minneapolis, MN; ²Biostatistics, University of MN, Minneapolis, MN; ³Pharmacy, University of MN, Minneapolis, MN; ⁴Surgery, University of MN, Minneapolis, MN; ⁵Medicine, University of PA, Philadelphia, PA.
Introduction: In our effort to personalize immunosuppressive therapies we performed RNA sequencing (RNAseq) to identify differentially expressed genes (DEGs) after kidney transplant (tx) and the…