Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Barriers and Facilitators to Care for Patients with Failed Kidney Transplants
A. Huml¹, K. Berg², A. Perzynski², C. Sullivan², A. Sehgal²
¹Department of Kidney Medicine, Cleveland Clinic, Cleveland, OH, ²Population Health Research Institute, The MetroHealth System, Cleveland, OH
*Purpose: To understand the barriers and facilitators to care for patients with failed kidney transplants from the perspective of providers.*Methods: Qualitative study employed focus groups…
2022 American Transplant Congress
First-in-Human Clinical-Grade Porcine Kidney Xenotransplant
J. E. Locke¹, B. Orandi¹, V. Kumar¹, J. Houp¹, D. Anderson¹, V. Hauptfeld¹, D. Martin², C. Killian¹, S. Macedon¹, N. Budd¹, K. Stegner¹, A. Dandro³, M. Kokkinaki³, K. Kuravi³, R. Reed⁴, H. Fatima¹, G. Baker¹, J. Perry¹, E. Bryant¹, M. Cheung¹, E. Erman¹, K. Kraebber¹, T. Gamblin¹, L. Guy¹, D. Ayares³, P. Porrett¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Deakin University, Geelong, Australia, ³Revivicor, Incorporated, Blacksburg, VA, ⁴University of Alabama at Birmingham, Irondale, AL
*Purpose: Proof-of-concept xenotransplant work has been performed in pig to non-human primates (NHP), but it is unclear if outcomes can be recapitulated in humans. While…
2022 American Transplant Congress
Which is More Important for Predicting De Novo DSA Production, B Cell Epitope (EPLET) or T Cell Epitope (PIRCHE) Analysis ?
T. Kobayashi¹, T. Tomosugi², S. Sakamoto², S. Ashimine¹, K. Iwasaki¹, M. Niemann³, E. Spierings⁴, Y. Miwa¹, M. Okumura¹, K. Ishiyama¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³PIRCHE AG, Berlin, Germany, ⁴UMC Utrecht, Utrecht, Netherlands
*Purpose: De novo donor-specific antibodies (dnDSA) can cause chronic ABMR, resulting in poor prognosis. Recently, mismatch at B cell epitope level, i.e. EPLET mismatch, has…
2022 American Transplant Congress
Preoperative Antibiotics Administration is Important to Prevent Hand Port-Site Infection After Hand-Assisted Laparoscopic Donor Nephrectomy for Living-Donor Kidney Transplantation
T. Hiramitsu, T. Tomosugi, K. Futamura, M. Okada, N. Goto, T. Ichimori, S. Narumi, Y. Watarai
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan
*Purpose: Due to the profound organ shortage, the number of living donor kidney transplantation (LDKT) is increasing. Hand-assisted laparoscopic donor nephrectomy (HALDN) is widely performed…
2022 American Transplant Congress
Landscape of Attitudes Towards Living Kidney Donation During the SARS-CoV-2 Pandemic in the United States: Results of a Public Opinion Survey
K. Kaplow¹, J. Ruck¹, A. Thomas¹, D. Warren¹, D. Segev¹, C. Corlett², J. Sinacore³, M. Levan¹
¹Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, ²Brand Planning LLC, Williamsburg, VA, ³National Kidney Registry, Babylon, NY
*Purpose: Solid organ transplantation decreased during the SARS-CoV-2 pandemic largely due to temporary shutdowns. The pandemic revealed significant gaps in medical knowledge among the public;…
2022 American Transplant Congress
HLA-DRB1 and DQB1 Amino Acid Mismatches as Determinants of Kidney Allograft Failure
L. Gragert¹, K. P. McCullough², G. L. Wager³, R. Urbanowicz⁴, R. M. Merion², M. Kamoun⁴
¹Tulane Cancer Center, Tulane University, New Orleans, LA, ²Arbor Research Collaborative for Health, Ann Arbor, MI, ³Tulane University, New Orleans, LA, ⁴University of Pennsylvania, Philadelphia, PA
*Purpose: It was previously reported that HLA-DRB1 amino acid (AA) mismatches (MMs) at peptide-binding pockets of this molecule account for significant incremental risk of kidney…
2022 American Transplant Congress
Trends of Living Kidney Donor Characteristics in the United States from 2000-2019
N. K. Prabhu¹, V. Villani¹, K. P. Samy¹, D. Sudan¹, K. Ravindra¹, W. Irish²
¹Surgery, Duke University Medical Center, Durham, NC, ²Surgery, East Carolina University, Greenville, NC
*Purpose: While studies have been performed analyzing recipient outcomes after extended criteria living donor kidney transplantation (LDKT), the actual long-term trends of demographic and medical…
2022 American Transplant Congress
Area Deprivation Index is Associated with Worse Patient Survival Following Adult Kidney Transplantation
J. Hendele¹, J. Perkins², J. Nichols³, A. Dick⁴
¹Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA, ²Clinical and Bio-Analytics Transplant Laboratory (CBATL), University of Washington, Seattle, WA, ³University of Washington School of Medicine, Seattle, WA, ⁴University of Washington School of Medicine Seattle, Seattle, WA
*Purpose: Area Deprivation Index (ADI) has been utilized as a granular measure of local socioeconomic status for nearly two decades. This study is the first…
2022 American Transplant Congress
Study Of Matrix Metalloproteinase (mmp) And Tissue Inhibitors Of Metalloproteinase (timp) Gene Polymorphisms In Renal Allograft Outcome
J. P. Tom¹, J. Singh¹, A. Sharma², R. Aggarwal¹, R. Nada³, R. Ramachandran⁴, S. Anand¹, R. Minz¹
¹Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ²Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ³Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ⁴Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
*Purpose: Our study aimed to find a role, if any, of functional gene polymorphisms of MMP and their inhibitors- TIMP in renal allograft outcome.*Methods: The…
2022 American Transplant Congress
Outcome of Kidney Transplantation in the Elderly Compared with Dialysis
B. Shi¹, T. Ying², S. Chadban²
¹University of Sydney, Camperdown, Australia, ²Royal Prince Alfred Hospital, Camperdown, Australia
*Purpose: Although kidney transplantation offers improved survival and quality of life compared to remaining on dialysis for most recipients, outcomes for elderly patients (older than…

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