Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Outcomes of Live Kidney Donors Who Develop End Stage Renal Disease
A. Muzaale, A. Massie, L. Kucirka, D. Segev.
Johns Hopkins, Baltimore.
Kidney donors can develop ESRD after donation, but the outcomes of those who do remain poorly characterized.Methods: Using USRDS and SRTR data, we compared access…
2015 American Transplant Congress
ASKP1240 in De Novo Kidney Transplant Recipients
R. Harland,¹ G. Klintmalm,² H. Yang,³ S. Jensik,⁴ T. Shah,⁵ P. West-Thielke,⁶ F. Shihab,⁷ W. Zhang,⁸ V. Santos,⁸ R. Tainaka,⁸ X. Wang,⁸ R. First,⁸ J. Holman.⁸
¹East Carolina University, Greenville, NC; ²Baylor University Medical Center, Dallas, TX; ³Pinnacle Health System, Harrisburg, PA; ⁴Rush University, Chicago, IL; ⁵Transplant Research Institute, Los Angeles, CA; ⁶University of Illinois Chicago, Chicago, IL; ⁷University of Utah Health Science Center, Salt Lake City, UT; ⁸Astellas Pharma Global Development, Northbrook, IL.
Primary objective was to evaluate the efficacy and safety of ASKP1240, antagonistic anti-CD40 antibody, in either a CNI free regimen or a CNI minimization regimen…
2015 American Transplant Congress
Evaluation of the Use of Leflunomide for the Prevention of BK Nephropathy in Renal Transplant Recipients- A Single Center Experience
S. Jonchhe, E. Hollinger, S. Jensik, O. Olaitan, A. Hodowanec, M. Hertl, S. Fayek, E. Chan, C. Pullum, N. Alvey.
Rush University Medical Center, Chicago, IL.
Objective: The purpose of this study was to compare the efficacy of leflunomide in combination with reduced immunosuppression versus reduction of immunosuppression alone for the…
2015 American Transplant Congress
An Investigation of 12 Cases of Membranous Nephropathy of the Donor Origin Accidentally Detected by 0-h Renal Biopsy During Kidney Transplantation
K. Unagami,¹ D. Toki,¹ M. Okumi,¹ H. Ishigooka,¹ K. Tsujimura,¹ T. Kanzawa,¹ K. Omoto,¹ H. Ishida,¹ K. Nitta,² K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan; ²Nephrology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
Membranous Nephropathy (MN) is a type of glomerulonephritis characterized by thickening of the glomerular basement membrane with immunoglobulin deposition. Proteinuria is a primary symptom, and…
2015 American Transplant Congress
Are AT1R Antibodies as Dangerous as HLA-DSAs in Renal Allografts?
E. Cuevas, J. Arreola-Guerra, E. Hernandez-Mendez, I. Salcedo, M. Vilatoba, A. Contreras, A. Sanchez-Cedillo, J. Ramirez, D. de Rungs, J. Granados, L. Morales-Buenrostro, J. Alberu.
1Transplantation, 1aNephrology-Mineral Metabolism, Inst Nal de Ciencias Medicas y Nutricion SZ, Mexico City, Distrito Federal, Mexico.
Angiotensin II type 1 receptor antibodies (AT1Rab) have been associated with a significantly lower graft survival and a higher risk of acute rejection after kidney…
2015 American Transplant Congress
Eculizumab in the Treatment of Early Severe Acute Antibody Mediated Rejection Following HLA-Compatible Kidney Transplantation-Case Series
M. Singh,¹ N. Macias,² V. Tatapudi,¹ B. Lee.¹
¹Transplant Nephrology, UCSF Medical Center, San Francisco, CA; ²Nephrology, Hospital Gregorio Maranon, Madrid, Spain.
Severe early acute antibody-mediated rejection (AMR) is associated with poor allograft outcomes. Eculizumab is a humanized mouse monoclonal antibody against complement factor C5 that has…
2015 American Transplant Congress
A Novel Maintenance Regimen With Calcineurin Inhibitor, MMF and Everolimus Initiated By Dual Induction Therapy With Anti-CD20/25 Antibodies in Renal Transplantation
N. Masaki, K. Iwado, I. Nakagima, S. Fuchinoue.
Surgery III, Tokyo Women's Medical University Hospital, Shinjuku-ku,Tokyo, Japan.
【background】Calcineurin inhibitor (CNI), MMF and steroid has been the gold standard of maintenance regimen in renal transplantation (RTx). A line of new immunosuppressants has emerged…
2015 American Transplant Congress
Pre-Transplant Weight Change and New-Onset Diabetes After Kidney Transplantation
E. Huang, B. Abdalla, M. Andre, S. Bunnapradist.
Dept of Medicine, UCLA School of Medicine, Los Angeles, CA.
Background:We studied the association between pre-transplant weight change and new-onset diabetes after kidney transplant (NODAT).Methods:Using OPTN/UNOS data with follow-up to October, 2012, all adult (age>18…
2015 American Transplant Congress
Incidence, Determinants and Outcome of Kidney Transplantation for End Stage Renal Disease After Heart Transplantation
A. Grupper,¹ A. Grupper,¹ R. Daly,¹ M. Hathcock,² W. Kremers,² F. Cosio,¹ B. Edwards,¹ S. Kushwaha.¹
¹William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN; ²Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
Objectives: Progressive renal failure is a frequent complication following heart transplantation (HTx), is generally attributed to calcineurin inhibitor (CNI) based immunosuppression, and may result in…
2015 American Transplant Congress
Gradual Warming Up Perfusion Post Static Cold Storage Reduces Renal Injury
P. Mahboub,^3,1 P. Ottens,¹ R. Ploeg,² P. Martins,³ H. Leuvenink.¹
¹Surgery, UMCG, Groningen, Netherlands; ²Surgery, University of Oxford, Oxford, United Kingdom; ³Surgery, UMass, Worcester, MA.
We hypothesize that the sudden warm reperfusion after Cold Storage [CS] is detrimental for the graft and we therefore evaluated different warming-up procedures before reperfusion.Methods:Rat…