Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Everolimus with Low-Dose Tacrolimus vs. a Standard Immunosuppressive Regimen: Renal Histology at 6 Months in De Novo Renal Transplant Patients.
S. Yilmaz,¹ D. Shaffer,² F. Shihab,³ K. McCague,⁴ D. Patel,⁴ Y. Qazi,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Utah, Salt Lake City, UT; ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁵University of Southern California, Los Angeles, CA; ⁶University of California San Francisco, San Francisco, CA.
Morphologic changes in transplant protocol biopsies provide early evidence of renal damage. This study examined the renal histology of de novo patients 6 months post…
2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
L. Wijermars, A. Schaapherder, J. Lindeman.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…
2016 American Transplant Congress
Pre-Transplant Bariatric Surgery and One-Year Graft Loss Risk in Kidney Transplants.
G. Mour, J. Zhang, Z. Su, D. Taber, P. Mauldin, T. Srinivas.
MUSC, Charleston.
Background: Several centers recommend bariatric surgery (BS) pre-transplantation (pre-Tx) with arbitrary BMI cutoffs. The effects of BS on Tx outcome are unclear. We studied the…
2016 American Transplant Congress
Early Alloantibody Responses Against Donor MHC Class I and Class II Molecules Are Differentially Affected by Prolonged Cold Ischemia Storage of Renal Allografts.
V. Gorbacheva, R. Fan, W. Baldwin, A. Valujskikh.
Immunology, Cleveland Clinic Foundation, Cleveland, OH.
Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury. Despite strong clinical correlations between…
2016 American Transplant Congress
Circulating Angiotensin II Receptor: Possible Marker for Antibody Mediated Tissue Injury?
P. Kimball, F. McDougan, G. Gupta.
Transplant Surgery, VCU Health, Richmond, VA.
Background. Antibody mediated rejection is the leading cause of renal allograft failure. Membrane-bound angiotensin II receptor(AngII) in the renal allograft can be a target of…
2016 American Transplant Congress
Polyclonal Treg Adoptive Therapy for Control of Subclinical Kidney Transplant Inflammation (TASK Pilot Trial).
S. Chandran, Q. Tang, M. Sarwal, Z. Laszik, A. Putnam, T. Sigdel, E. Tavares, J. Bluestone, F. Vincenti.
UCSF, San Francisco, CA.
Purpose: Early renal graft inflammation is associated with progressive fibrosis & late dysfunction. Treg therapy can reverse established inflammation in animal models. We conducted a…
2016 American Transplant Congress
Short Term Changes in HRQOL Following Kidney Transplantation.
I. Olorundare, H. Ying, M. McAdams-DeMarco, D. Segev.
JHU, Baltimore.
Health-Related Quality of Life (HRQOL) is a patient-centered outcome that measures the impact of a disease and its treatment. This is particularly relevant to those…
2016 American Transplant Congress
Renal Outcome with Eculizumab in Patients with aHUS with Native and Transplanted Kidneys: Pooled Analysis of 100 Patients.
C. Legendre,¹ J. Campistol,² T. Feldkamp,³ J. Wang,⁴ G. Remuzzi,⁵ L. Weekers,⁶ N. Sheerin.⁷
¹Université Paris Descartes & Hôpital Necker, Paris, France; ²Hospital Clinic, University of Barcelona, Barcelona, Spain; ³University Hospital Schleswig-Holstein, Kiel, Germany; ⁴Alexion Pharmaceuticals, Inc., Cheshire, CT; ⁵IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy; ⁶CHU de Liège, Liège, Belgium; ⁷Newcastle University, Newcastle upon Tyne, United Kingdom.
Purpose: aHUS often progresses to ESRD and requires transplant (tx). Eculiumab (ECU), a terminal complement inhibitor, inhibits TMA irrespective of tx status. We evaluated outcomes…
2016 American Transplant Congress
De Novo Anti-HLA DSA Characteristics and Subclinical Antibody Mediated Kidney Allograft Injuries.
T. Yamamoto, Y. Watarai, A. Takeda, M. Okada, M. Tsujita, T. Hiramitsu, N. Goto, S. Narumi, K. Morozumi, K. Uchida, T. Kobayashi.
Nagoya daini red cross hospital, Nagoya, Japan.
Background It has been reported that de novo donor-specific HLA antibody (dn DSA) production is associated with chronic antibody-mediated rejection (CAMR) which leads to poor…
2016 American Transplant Congress
A Non-Invasive Blood Transcriptional Assay, Ksort, Monitors Alloimmune Response in the Sailor Randomized Multicenter Trial.
J. Ekberg,¹ B. Jespersen,² K. Skov,² M. Sarwal,³ T. Sigdel,³ S. Hsieh,³ P. Lindner.¹
¹Transplantation, Sahlgrenska University Hospital, Gothenburg, Sweden; ²Nephrology, Skejby Hospital, Aarhus, Denmark; ³Surgery, University of California, San Francisco.
Non-invasive diagnosis and prediction of acute rejection (AR) is a critical unmet need. A In a randomized multicenter trial of 222 renal transplant recipients a…