Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Outcomes of Pediatric en Bloc Kidney (PeB) Grafts After Loss of a Single Kidney.
C. Santhanakrishnan, R. Perez, J. McVicar, J. Sageshima, C. Troppmannn.
Division of Transplantation, Dept of Surgery, Univ of Calif Davis Medical Center, Sacramento, CA.
Background: Transplantation (Tx) of PeB kidney grafts has been shown to result in good long-term outcomes. However, the fate of PeB grafts that suffer loss…
2016 American Transplant Congress
Initial Experience with Donor Specific Tregs in Kidney Transplantation.
J. Markmann,¹ E. Guinan,² E. Geissler,³ G. Cole,² S. Germana,¹ J. Kim,¹ B. Sawitzki.⁴
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Hematology/Oncology, Dana-Farber Cancer Center, Boston, MA; ³Surgery, Universitätsklinikum Regensburg, Regensburg, Germany; ⁴Institute of Medical Immunology, Charite Universitätsmedizin, Berlin, Germany.
Systematic multicenter clinical evaluation of regulatory cells is being conducted by the EU supported ONE Study trial in which each site is administering a different…
2016 American Transplant Congress
Everolimus with Low-Dose Tacrolimus vs. a Standard Immunosuppressive Regimen: Renal Histology at 6 Months in De Novo Renal Transplant Patients.
S. Yilmaz,¹ D. Shaffer,² F. Shihab,³ K. McCague,⁴ D. Patel,⁴ Y. Qazi,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Utah, Salt Lake City, UT; ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁵University of Southern California, Los Angeles, CA; ⁶University of California San Francisco, San Francisco, CA.
Morphologic changes in transplant protocol biopsies provide early evidence of renal damage. This study examined the renal histology of de novo patients 6 months post…
2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
L. Wijermars, A. Schaapherder, J. Lindeman.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…
2016 American Transplant Congress
Pre-Transplant Bariatric Surgery and One-Year Graft Loss Risk in Kidney Transplants.
G. Mour, J. Zhang, Z. Su, D. Taber, P. Mauldin, T. Srinivas.
MUSC, Charleston.
Background: Several centers recommend bariatric surgery (BS) pre-transplantation (pre-Tx) with arbitrary BMI cutoffs. The effects of BS on Tx outcome are unclear. We studied the…
2016 American Transplant Congress
Early Alloantibody Responses Against Donor MHC Class I and Class II Molecules Are Differentially Affected by Prolonged Cold Ischemia Storage of Renal Allografts.
V. Gorbacheva, R. Fan, W. Baldwin, A. Valujskikh.
Immunology, Cleveland Clinic Foundation, Cleveland, OH.
Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury. Despite strong clinical correlations between…
2016 American Transplant Congress
Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.
J. Reeve,¹ P. Halloran.^1,2
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…
2016 American Transplant Congress
A Molecular Biopsy Test for Probability of Non-Adherence.
P. Halloran,^1,3 G. Einecke,² J. Reeve.¹
¹ATAGC, Edmonton, AB, Canada; ²Hannover Medical School, Hannover, Germany; ³Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
2016 American Transplant Congress
Association of Pre-Transplant Midodrine Use and Complications After Kidney Transplantation.
T. Alhamad,¹ D. Brennan,¹ Z. Brifkani,¹ H. Xiao,² M. Schnitzler,² V. Dharnidharka,¹ D. Axelrod,³ D. Segev,⁴ K. Lentine.²
¹Washington University, St. Louis; ²Saint Louis University, St. Louis; ³Dartmouth Hitchcock Medical Center, Hanover; ⁴Johns Hopkins University, Baltimore.
Background: Midodrine is increasingly prescribed to decrease the severity and complications of hypotension in dialysis patients. The impacts of midodrine use before kidney transplantation on…
2016 American Transplant Congress
Early Post Renal Transplant aHUS in Patients with Heterozygous CFHR3-CFHR1 Deletion.
S. Rhazouani, A. Malone, T. Alhamad, T. Maw, D. Brennan, R. Delos Santos.
Renal Division, Washington University, Saint Louis, MO.
Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease with a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Subjects homozygous for…