Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Deep Learning Identifies Arterial Intimal Fibrosis in Kidney Transplant Biopsies
K. Liu¹, Z. Yi², S. Ward³, F. Salem³, W. Zhang²
¹Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ³Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Arterial intimal fibrosis (AIF) is the excessive fibrotic tissue formation in the intima of arteries indicative of poor graft function after kidney transplant. Visual…
2022 American Transplant Congress
DCD and AKI Kidneys Experiencing DGF as a Platform for the Study of Adaptive Repair
B. Bussolati¹, S. Da Sacco², A. Asthana³, L. N. Byers³, L. Perin⁴, M. S. Garner³, B. Sharda³, A. C. Farney³, C. J. Jay³, R. J. Stratta³, S. J. Walker⁵, G. Orlando³
¹University of Turin, Turin, Italy, ²Children Hospital Los Angeles, Los Angeles, NC, ³Wake Forest Baptist Medical Center, Winston-Salem, NC, ⁴Children Hospital Los Angeles, Los Angeles, CA, ⁵WFIRM, Winston-Salem, NC
*Purpose: AKI and DCD renal allografts are at high risk for DGF, yet the majority of these kidneys will eventually recover and attain good function…
2022 American Transplant Congress
Interaction Between Financial Barriers and Other Motivators, Barriers, and Facilitators of Living Organ Donation
A. R. Smith¹, R. J. Mandell¹, M. E. Helmuth¹, N. P. Goodrich¹, J. B. Wiseman¹, K. A. Gifford², M. A. Fava¹, A. O. Ojo³, R. M. Merion¹, A. K. Mathur⁴
¹Arbor Research Collaborative for Health, Ann Arbor, MI, ²American Society for Transplant Surgeons, Arlington, VA, ³University of Kansas Medical Center, Kansas City, KS, ⁴Mayo Clinic, Phoenix, AZ
*Purpose: Our objective was to assess how financial barriers to living donation interact with other motivators, barriers, and facilitators during the decision-making process.*Methods: Data were…
2022 American Transplant Congress
Comparative Analysis of kSORT Assay for Predicting Acute Renal Allograft Rejection Under Belatacept-Based Immunosuppression
H. Hames¹, M. Sarwal², I. Damm², E. Yanqui¹, A. Burg¹, A. Christianson¹, A. R. Shields¹, D. Hildeman¹, R. R. Alloway¹, E. S. Woodle¹
¹University of Cincinnati, Cincinnati, OH, ²University of California San Francisco, San Francisco, CA
*Purpose: The kSORT (Kidney Solid Organ Response Test) assay uses transcriptomic profiling of peripheral blood to predict the presence of acute rejection (AR) in renal…
2022 American Transplant Congress
Association Between De Novo Donor Specific Antibody and Tacrolimus Trough Levels in Long Term Follow Up Renal Transplantation
N. Fujiyama¹, M. Saito², R. Yamamoto², R. Sagehashi², T. Saito², Y. Aoyama², K. Numakura², T. Habuchi², S. Satoh¹
¹Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan, ²Department of Urology, Akita University Graduate School of Medicine, Akita, Japan
*Purpose: In this study, we aimed to identify the risk factors contributing to the development of donor-specific anti-HLA antibody (DSA) during long-term follow-up of patients…
2022 American Transplant Congress
Variability of Serum Klotho and FGF-23 Levels During the First Two Years After Kidney Transplantation
T. Vazquez-Sanchez¹, M. Sanchez-Niño², P. Ruiz-Esteban¹, V. López¹, J. Delgado¹, A. Ortiz³, D. Hernández¹
¹Nephrology Department, Regional University Hospital (IBIMA), REDinREN (RD16/0009/0006), Malaga (España), Malaga, Spain, ²Nephrology Department, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid. REDINREN, Madrid, Spain, ³Nephrology Department, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid. REDINREN, Madrid, Spain, Madrid, Spain
*Purpose: Klotho is a protein produced in renal tubular cells with nephroprotective actions which acts as a co-receptor for phosphaturic factor FGF-23. The natural history…
2022 American Transplant Congress
Results Of The Ctot19 Trial: Infliximab (IFX) Induction Does Not Impact 2-year Outcomes In Deceased Donor Kidney Transplant Recipients
P. Heeger¹, B. Armstrong², T. Alhamad³, D. Brennan⁴, J. Bromberg⁵, S. Bunnapradist⁶, S. Chandran⁷, R. Fairchild⁸, D. Foley⁹, R. Formica¹⁰, I. W. Gibson¹¹, D. Hricik¹², K. Kesler², R. B. Mannon¹³, M. Menon¹⁰, K. Newell¹⁴, P. Nickerson¹¹, J. Odim¹⁵, E. Poggio⁸, R. Sung¹⁶, R. Shapiro¹, K. Tinckam¹⁷, F. Vincenti⁷
¹Mount Sinai, New York, NY, ²Rho, Durham, NC, ³Washington U, Saint Louis, MO, ⁴Johns Hopkins, Baltimore, MD, ⁵U Maryland, Baltimore, MD, ⁶UCLA, Los Angeles, CA, ⁷UCSF, San Francisco, CA, ⁸Cleveland Clinic, Cleveland, OH, ⁹U Wisconsin, Madison, WI, ¹⁰Yale, New Haven, CT, ¹¹U Manitoba, Winnipeg, MB, Canada, ¹²U Hosp Case, Cleveland, OH, ¹³U Nebraska, Omaha, NE, ¹⁴Emory, Atlanta, GA, ¹⁵NIAID NIH, Rockville, MD, ¹⁶U Michigan, Ann Arbor, MI, ¹⁷U Hlth Network, Toronto, ON, Canada
*Purpose: Ischemia-reperfusion (IR) of a kidney transplant (KTx) up-regulates tumor necrosis factor alpha (TNF) production within the allograft. IR-induced TNF amplifies post-KTx allograft inflammation and…
2022 American Transplant Congress
Longitudinal Mortality Risks and Renal Functional Outcomes in Living Kidney Donors
K. Hotta¹, T. Osawa¹, I. Yokota², T. Inao², T. Tanabe¹, N. Iwahara¹, N. Shinohara¹
¹Urology, Hokkaido University Hospital, Sapporo, Japan, ²Biostatistics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
*Purpose: Previous studies have suggested that living kidney donors do not have a higher risk of death or end-stage kidney disease (ESKD) than the general…
2022 American Transplant Congress
Pegloticase for Uncontrolled Gout in Kidney Transplant Recipients: Provisional Data Report of a Multicenter, Open-Label, Efficacy and Safety Study
A. Abdellatif¹, L. Zhao², K. Cherny², B. Marder², J. D. Scandling³, K. Saag⁴
¹Division of Nephrology, Baylor College of Medicine, Houston, TX, ²Horizon Therapeutics PLC, Deerfield, IL, ³Division of Nephrology, Stanford School of Medicine, Stanford, CA, ⁴Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Gout in kidney transplant (KT) recipients can be severe and particularly challenging to manage. Pegloticase co-therapy with immunomodulators improved urate lowering therapy (ULT) response…
2022 American Transplant Congress
Bisphosphonates for Fracture Prevention in Kidney Transplant Recipients
J. Kahwaji¹, S. Yang², J. Sim³
¹Nephrology/Transplant, Kaiser Los Angeles Medical Center, Los Angeles, CA, ²Research and Evaluation, Kaiser-Permanente, Pasadena, CA, ³Nephrology, Kaiser Los Angeles Medical Center, Los Angeles, CA
*Purpose: Kidney transplant recipients are at increased risk of fracture, however bisphosphonate use has not be shown to lower fracture risk in this population. We…