Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Cold Pulsatile Perfusion Preservation of Deceased Donor Kidneys Did Not Improve Delayed Graft Function Rates in Most Transplants Due to Longer Cold Ischemia Times Offsetting Much of the Benefit, Analysis of SRTR Database
D. S. Keith, E. Lessmann
Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL
*Purpose: To determine the impact of cold pulsatile perfusion preservation (CPPP) on delayed graft function (DGF) in a national cohort of US kidney transplants as…
2022 American Transplant Congress
Prediction of Delayed Graft Function After Deceased Donor Kidney Transplantation Using Machine Learning and Sequential Donor Data
J. Sageshima¹, J. Yu¹, H. Lala Gul¹, F. De Leon¹, N. Goussous¹, N. Mineyev¹, P. Than¹, K. Jen², R. Perez¹
¹Surgery, University of California Davis Health, Sacramento, CA, ²Pathology, University of California Davis Health, Sacramento, CA
*Purpose: Delayed graft function (DGF) has been associated with adverse kidney transplant outcomes. Accurate prediction of DGF before surgery will help select organs and candidates…
2022 American Transplant Congress
Deep Learning Identifies Arterial Intimal Fibrosis in Kidney Transplant Biopsies
K. Liu¹, Z. Yi², S. Ward³, F. Salem³, W. Zhang²
¹Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ³Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Arterial intimal fibrosis (AIF) is the excessive fibrotic tissue formation in the intima of arteries indicative of poor graft function after kidney transplant. Visual…
2022 American Transplant Congress
DCD and AKI Kidneys Experiencing DGF as a Platform for the Study of Adaptive Repair
B. Bussolati¹, S. Da Sacco², A. Asthana³, L. N. Byers³, L. Perin⁴, M. S. Garner³, B. Sharda³, A. C. Farney³, C. J. Jay³, R. J. Stratta³, S. J. Walker⁵, G. Orlando³
¹University of Turin, Turin, Italy, ²Children Hospital Los Angeles, Los Angeles, NC, ³Wake Forest Baptist Medical Center, Winston-Salem, NC, ⁴Children Hospital Los Angeles, Los Angeles, CA, ⁵WFIRM, Winston-Salem, NC
*Purpose: AKI and DCD renal allografts are at high risk for DGF, yet the majority of these kidneys will eventually recover and attain good function…
2022 American Transplant Congress
Interaction Between Financial Barriers and Other Motivators, Barriers, and Facilitators of Living Organ Donation
A. R. Smith¹, R. J. Mandell¹, M. E. Helmuth¹, N. P. Goodrich¹, J. B. Wiseman¹, K. A. Gifford², M. A. Fava¹, A. O. Ojo³, R. M. Merion¹, A. K. Mathur⁴
¹Arbor Research Collaborative for Health, Ann Arbor, MI, ²American Society for Transplant Surgeons, Arlington, VA, ³University of Kansas Medical Center, Kansas City, KS, ⁴Mayo Clinic, Phoenix, AZ
*Purpose: Our objective was to assess how financial barriers to living donation interact with other motivators, barriers, and facilitators during the decision-making process.*Methods: Data were…
2022 American Transplant Congress
Comparative Analysis of kSORT Assay for Predicting Acute Renal Allograft Rejection Under Belatacept-Based Immunosuppression
H. Hames¹, M. Sarwal², I. Damm², E. Yanqui¹, A. Burg¹, A. Christianson¹, A. R. Shields¹, D. Hildeman¹, R. R. Alloway¹, E. S. Woodle¹
¹University of Cincinnati, Cincinnati, OH, ²University of California San Francisco, San Francisco, CA
*Purpose: The kSORT (Kidney Solid Organ Response Test) assay uses transcriptomic profiling of peripheral blood to predict the presence of acute rejection (AR) in renal…
2022 American Transplant Congress
No Difference in Graft Survival Among Low Socioeconomic Kidney Allograft Recipients
A. Desai¹, S. Akkina¹, K. Cmunt², D. Jain¹, R. Garcia-Roca³
¹Transplant Nephrology, Loyola University Medical Center, Maywood, IL, ²Gift Of Hope Community Foundation, Itasca, IL, ³Transplant Surgery, Loyola University Medical Center, Maywood, IL
*Purpose: Low socioeconomic status remains a barrier in access and equity in kidney transplantation with limited data assessing post-transplant outcomes. Alternative options to transplantation include…
2022 American Transplant Congress
A Novel Mismatch That Modulates the Innate Alloresponse Risk Stratifies Renal Transplant Patients
H. Dai, K. Abou Daya, M. Oberbarnscheidt, R. Mehta, C. Macedo, D. Metes, Q. Xu, A. Zeevi, P. Randhawa, F. Lakkis, A. Cherukuri
Thomas E. Starzl Transplantation Institute, UPMC, Pittsburgh, PA
*Purpose: Donor polymorphism in the gene encoding signal regulatory protein alpha (SIRPα) is a key modulator of the recipient’s innate alloresponse. Here, we investigated the…
2022 American Transplant Congress
Results Of The Ctot19 Trial: Infliximab (IFX) Induction Does Not Impact 2-year Outcomes In Deceased Donor Kidney Transplant Recipients
P. Heeger¹, B. Armstrong², T. Alhamad³, D. Brennan⁴, J. Bromberg⁵, S. Bunnapradist⁶, S. Chandran⁷, R. Fairchild⁸, D. Foley⁹, R. Formica¹⁰, I. W. Gibson¹¹, D. Hricik¹², K. Kesler², R. B. Mannon¹³, M. Menon¹⁰, K. Newell¹⁴, P. Nickerson¹¹, J. Odim¹⁵, E. Poggio⁸, R. Sung¹⁶, R. Shapiro¹, K. Tinckam¹⁷, F. Vincenti⁷
¹Mount Sinai, New York, NY, ²Rho, Durham, NC, ³Washington U, Saint Louis, MO, ⁴Johns Hopkins, Baltimore, MD, ⁵U Maryland, Baltimore, MD, ⁶UCLA, Los Angeles, CA, ⁷UCSF, San Francisco, CA, ⁸Cleveland Clinic, Cleveland, OH, ⁹U Wisconsin, Madison, WI, ¹⁰Yale, New Haven, CT, ¹¹U Manitoba, Winnipeg, MB, Canada, ¹²U Hosp Case, Cleveland, OH, ¹³U Nebraska, Omaha, NE, ¹⁴Emory, Atlanta, GA, ¹⁵NIAID NIH, Rockville, MD, ¹⁶U Michigan, Ann Arbor, MI, ¹⁷U Hlth Network, Toronto, ON, Canada
*Purpose: Ischemia-reperfusion (IR) of a kidney transplant (KTx) up-regulates tumor necrosis factor alpha (TNF) production within the allograft. IR-induced TNF amplifies post-KTx allograft inflammation and…
2022 American Transplant Congress
Longitudinal Mortality Risks and Renal Functional Outcomes in Living Kidney Donors
K. Hotta¹, T. Osawa¹, I. Yokota², T. Inao², T. Tanabe¹, N. Iwahara¹, N. Shinohara¹
¹Urology, Hokkaido University Hospital, Sapporo, Japan, ²Biostatistics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
*Purpose: Previous studies have suggested that living kidney donors do not have a higher risk of death or end-stage kidney disease (ESKD) than the general…