Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Validation of a Simplified Cost-Effective Clinical Risk Stratification That Predicts Myocardial Ischemic Events in Kidney Transplant Candidates.
T. Jiamjariyapon,^1,2 N. Townamchai,^2,3 N. Garg,² M. Pavlakis,² A. Chandraker.²
¹Bhumirajanagarindra Kidney Institute, Bangkok, Thailand; ²Division of Nephrology, Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; ³Division of Nephrology, Chulalongkorn University, Bangkok, Thailand.
Background: Diagnosis of coronary artery disease before kidney transplantation is crucial in decreasing morbidity and mortality & avoiding the need for angiography in kidney transplant…
2016 American Transplant Congress
Early Conversion to Everolimus in De Novo Renal Transplant Recipients: Incidence of Viral Infections in the Randomized-Controlled ELEVATE Study.
H. Hirsch,¹ J. De Fijter,¹ M. van der Giet,¹ M. Zeier,¹ J. Pascual,¹ Y. Avihingsanon,¹ P. Lopez,² J. Aguilar-Sanchez,² J. Kochuparampil,² Z. Wang,³ H. Holdaas,¹ J. Cruzado.¹
¹ELEVATE Study Group, Basel, Switzerland; ²Novartis, Basel, Switzerland; ³Novartis Pharmaceutical Corporation, East Hanover.
BackgroundCytomegalovirus (CMV) and BK polyomavirus (BKPyV) infections are independent risk factors for acute rejection and graft loss. Early conversion from calcineurin inhibitors (CNIs) to everolimus…
2016 American Transplant Congress
Early Hospital Readmission Following Pediatric Kidney Transplantation.
E. King, L. Kucirka, M. McAdams-DeMarco, S. Bae, D. Segev.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: Approximately 31% of all adult kidney transplant (KT) recipients experience early hospital readmission and it is associated with inferior post-KT survival. Given the significant…
2016 American Transplant Congress
Mycophenolic Acid Product Discontinuation Prior to Conception: Analysis of Pregnancies in Kidney Transplant Recipients.
S. Constantinescu,^1,2 L. Coscia,² D. Armenti,² M. Moritz.^2,3
¹Medicine, Temple University, Philadelphia, PA; ²Gift of Life Institute, National Transplantation Pregnancy Registry (NTPR), Philadelphia, PA; ³Surgery, Lehigh Valley Health Network, Allentown, PA.
Mycophenolic acid (MPA) products are considered teratogenic and transplant centers report discontinuing MPA in female kidney recipients anticipating pregnancy. Data were collected by the National…
2016 American Transplant Congress
The Impact of Body Mass Index > 35 on Kidney Transplant Outcomes: A Systematic Review.
D. Walczak, E. Benedetti.
Organ Transplant, University of Illinois Hospital and Health Sciences System, Chicago, IL.
Background: The increased prevalence of obesity (BMI > 30) among adults in the United States over the last two decades is reflected in the number…
2016 American Transplant Congress
Understanding the Initial Rise in Kidney Discard Rates Observed Post-KAS.
D. Stewart,¹ A. Kucheryavaya,¹ R. Brown,¹ D. Klassen,¹ N. Turgeon,² M. Aeder.³
¹UNOS, Richmond, VA; ²Emory Univ, Atlanta, GA; ³Univ Hosp Case Med Ctr, Cleveland, OH.
Background: Kidney discard rates increased by 10% -- from 18.3% to 20.2% (p=0.001) -- during the first 7 months of KAS but returned to pre-KAS…
2016 American Transplant Congress
99% and 100% CPRA Patients Since KAS: A Substantial Increase in Transplants with Strong Evidence of a Bolus Effect.
A. Kucheryavaya,¹ M. Aeder,² N. Turgeon,³ D. Klassen,¹ D. Stewart.¹
¹UNOS, Richmond, VA; ²Univ Hosp Case Med Ctr, Cleveland, OH; ³Emory Univ Hosp, Atlanta, GA.
Background: The Kidney Allocation System (KAS), implemented on 12/4/14, increased allocation priority for candidates with CPRA of 99-100%. Analyses performed on behalf of the OPTN…
2016 American Transplant Congress
A Pathway to Belatacept Monotherapy: Alemtuzumab, Belatacept and Rapamycin for Kidney Transplantation.
A. Guasch,¹ H. Xu,² A. Mehta,¹ A. Ghali,¹ S. Mead,¹ H. Gebel,¹ R. Bray,¹ C. Larsen,¹ T. Pearson,¹ A. Kirk.²
¹Emory Transplant Center, Atlanta, GA; ²Duke University, Durham, NC.
Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative delivered by monthly intravenous infusion, but…
2016 American Transplant Congress
Better Never Than Late: Differences in Outcomes and Risk Factors for Early and Late Rejection After Kidney Transplantation.
A. Liu, N. Sarabu, A. Joshua.
Medicine, University Hospitals Case Medical Center, Cleveland, OH.
Background: Late acute rejection (AR) is associated with inferior outcomes relative to early AR after kidney transplantation. We sought to examine the differences in risk…
2016 American Transplant Congress
Is C3d-fixing Donor Specific HLA Antibody Detection Really Necessary?
P. Malvezzi,¹ M. Villemaire,¹ A. Bourdin,² T. Jouve,¹ R. Tetaz,¹ B. Janbon,¹ N. Terrier,³ D. Masson.²
¹Service de Néphrologie, Grenoble University Hospital, Grenoble, France; ²Laboratoire d'Histocompatibilité, EFS, Grenoble, France; ³Service d'Urologie, Grenoble University Hospital, Grenoble, France.
Introduction: Chronic antibody–mediated rejection is the main cause of late kidney graft loss. The identification of donor-specific antibodies (DSA) in the serum is one of…