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American Transplant Congress abstracts

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Articles tagged "Kidney transplantation"

  • 2016 American Transplant Congress

    U.S. Dialysis Facility Characteristics Associated with Racial Disparities in Access to the Kidney Deceased Donor Transplant Waiting List.

    J. Gander, L. Plantinga, S. Paul, S. Pastan, R. Patzer.

    Emory University, Atlanta.

    BACKGROUND Dialysis facility characteristics have been significantly associated with variation in U.S. transplant rates but facility characteristics associated with disparities in access to the kidney…
  • 2016 American Transplant Congress

    HLA Antibody in Transplant Recipients During Transition from Paediatrics.

    S. Kaki,1 A. Lunn,2 J. Goodwin,3 T. Key,3 W. McKane.1

    1Renal, Sheffield Kidney Institute, Sheffield, United Kingdom; 2Renal, Queens Medical Centre, Sheffield, United Kingdom; 3Histocompatibility and Immunogenetics, National Health Service blood and transplantation, Sheffield, United Kingdom.

    Objective:Adolescent transplant recipients in transition from paediatric to adult units are known to be at high risk of graft failure. Detection of HLA antibody is…
  • 2016 American Transplant Congress

    Mining the Human Proteome for Monitoring Renal Transplant Injury.

    T. Sigdel,1 Y. Gao,2 J. He,2 A. Wang,1 C. Nicora,2 D. Smith,2 W. Qian,2 D. Camp,2 M. Sarwal.1

    1Surgery, University of California-San Francisco, San Francisco; 2Pacific Northwest National Laboratory, Richland.

    The human urinary proteome reflects systemic and inherent renal injury perturbations and can be harnessed to define biomarkers for different kidney transplant injury states. Through…
  • 2016 American Transplant Congress

    Accumulation of Highly Sensitized Patients in a KPD Registry.

    S. Stepkowski, B. Mierzejewska, D. Bekbolsynow, M. Rees.

    University of Toledo, Toledo, OH.

    Objectives: We analyzed sensitization against HLA among patients in a kidney paired donation (KPD) registry. In particular, three groups of patients were included: 1) all…
  • 2016 American Transplant Congress

    Angiotensin II Type-1 Receptor Antibodies in Renal Transplant Recipients Associated with Ventricular and Endothelial Dysfunction: Preliminary Results.

    L. Figuerola-Chaparro,1 F. Davila-Radilla,1 E. Cuevas,2 L. Castillo-Martínez,1 A. Orea-Tejeda,1 J. Arreola-Guerra,2 J. Alberu.2

    1Cardiology, Inst Nal Ciencias Medicas y Nutricion SZ, Mexico City, Mexico; 2Transplantation, Inst Nal Ciencias Medicas y Nutricion SZ, Mexico City, Mexico.

    Previous studies demonstrated the significance of angiotensin II type-1 receptor antibodies (AT1Rabs) in processes including hypertension, cardiac hypertrophy and renal fibrosis; information regarding ventricular and…
  • 2016 American Transplant Congress

    End-Stage Renal Disease Does Not Impair the Large-Scale Generation of Potent Alloantigen-Specific Regulatory T Cells for Immunotherapy.

    N. Litjens, K. Boer, J. Zuijderwijk, M. Klepper, A. Peeters, W. Verschoor, R. Kraaijeveld, C. Baan, M. Betjes.

    Internal Medicine, Nephrology and Transplantation, Erasmus University Medical Centre, Rotterdam, Netherlands.

    Background Alloantigen-specific natural occurring regulatory T cells (nTregs) have the potential to offer a more targeted approach of immunosuppression and are the cell type of…
  • 2016 American Transplant Congress

    Donor HLA Specific IgM Antibody Measured on Day 14 Post-Transplantation Predicts Poor Graft Survival in HLA-Incompatible Renal Transplantation.

    A. Babu, A. Androeu, S. Daga, R. Higgins, D. Mitchell, D. Briggs, N. Khovanova, N. Krishnan.

    Renal Medicine, University Hospital Coventry and Warwickshire, Coventry, West Midlands, United Kingdom; Life Sciences, University of Warwick, Coventry, West Midlands, United Kingdom; Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, West Midlands, United Kingdom; School of Engineering, University of Warwick, Coventry, United Kingdom.

    Introduction: Role of IgG antibodies against donor human leucocyte antigens (HLA) is established in renal transplant monitoring. Role of IgM donor HLA specific antibodies (DSA)…
  • 2016 American Transplant Congress

    Biopsies for Delayed Graft Function After Alemtuzumab Induction in Kidney Transplantation: The Incidence of Early Rejection After Alemtuzumab Is Very Low but Not Negligible.

    E. McGuire, C. Roufosse, T. Cook, D. Ashby, T. Cairns, J. Galliford, M. Willicombe, D. Taube, A. McLean.

    Imperial Kidney & Transplant Centre, Hammersmith Hospital, Imperial College Healthcare, London, United Kingdom.

    IntroductionUK practice advocates transplant biopsy (Bx) at day 7, then weekly in the presence of delayed graft function (DGF) because if missed, early rejection adversely…
  • 2016 American Transplant Congress

    Urinary Expression of miRNA-155, miRNA-210, miRNA-142 and CXCL-10 Production Predicts the Risk of Acute Rejection and Graft Outcome in Renal Transplant Recipients.

    O. Millan,1 K. Budde,2 C. Sommerer,3 I. Aliart,1 O. Rissling,2 B. Bardaji,4 M. Matz,2 M. Zeier,3 I. Silva,4 L. Guirado,4 M. Brunet.1

    1Pharmacology Laboratory, CDB, IDIBAPS, Hospital Clinic Barcelona, Barcelona University, Barcelona, Spain; 2Medizinische Klinik mit Schwerpunkt Nephrologie, Charité Universitätsmedizin, Berlin, Germany; 3Department of Nephrology, University Hospital Heidelberg and Mannheim, Heidelberg, Germany; 4Renal Transplant Unit, Fundació Puigvert, Barcelona, Spain.

    MicroRNAs (miRs) have been reported to play a role in immune system response. The results of several clinical trials have suggested that these molecules might…
  • 2016 American Transplant Congress

    Do Highly Sensitized Recipients Benefit from the Immunological Advantages of Zero Mismatched (0MM) Deceased Donors (DD) Kidney Allografts?

    N. Elfadawy,1 S. Flechner,2 J. Schold.2

    1Internal Medicine, Case Western Reserve University, Cleveland, OH; 2Glickman urological and kidney institute, Cleveland Clinic, Cleveland, OH.

    HLA 0MM DD transplants have superior outcomes compared with outcomes for grafts with ≥1 HLA mismatches, but when past reports analyzed 0MM outcomes in DD,…
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