Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Phenotype and Outcome of Antibody-Mediated Rejection Due to Pre-Existing and De Novo DSA in Kidney Recipients.
O. Aubert,¹ A. Loupy,¹ L. Hidalgo,² J. Reeve,³ D. Glotz,¹ C. Legendre,¹ C. Lefaucheur,¹ P. Halloran.³
¹Paris Research Center for Organ Transplantation, Paris, France; ²University of Alberta, Edmonton, Canada; ³ATAGC, Edmonton, Canada.
Antibody-mediated rejection (ABMR) presents with either pre-existing or de novo DSA. The aim of the study was to compare the two ABMR phenotypes and their…
2016 American Transplant Congress
mRNA Expression of BAFF and APRIL Receptors Increases in Acute Rejection in Kidney Transplant Recipients.
M. Minz,¹ R. Dhital,¹ R. Minz,² A. Sharma,¹ R. Nada,³ S. Singh,¹ D. Kenwar.¹
¹Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India; ²Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; ³Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Introduction:BAFF and APRIL are known survival and growth of B- cells.BAFF and APRIL share two receptors i-TACI and ii- BCMA. Additionally, BAFF has strong affinity…
2016 American Transplant Congress
Analysis of Broken Chains in Kidney Paired Donation During an 8 Year Period within the National Kidney Registry.
N. Cowan,¹ J. Sinacore,² H. Gritsch,¹ J. Veale.¹
¹Department of Urology, University of California - Los Angeles Medical Center, Los Angeles, CA; ²National Kidney Registry, Babylon, NY.
Purpose: Chain transplantation in kidney paired donation (KPD) offers the ability to facilitate multiple kidney transplants between incompatible pairs using a non-directed donor (NDD) to…
2016 American Transplant Congress
Predictors of Postoperative Cardiovascular Complications Until Three Months After Kidney Transplantation.
M. Slot,^1,2 J. van de Wetering,¹ M. Kho,¹ M. Betjes,¹ J. Roodnat.¹
¹Nephrology, Erasmus Medical Center, Rotterdam, Netherlands; ²Nephrology, VU Medical Center, Amsterdam, Netherlands.
Purpose: To identify factors involved in cardiac events within three months after renal transplantation.Methods: We conducted a chart review for all renal transplants (RT) performed…
2016 American Transplant Congress
IL2 and IL-15 Rescue TEMRA CD8 T Cells from Mitochondrial Dysfunction Associated Senescence Through a p38MAPK Dependent Pathway and Foster Their Pathogenic Potential.
G. Tilly,^1,2 M. Yap,^1,2 M. Giral,^1,2,3 C. Pecqueur,⁴ S. Brouard,^1,3 N. Degauque.^1,3
¹UMR1064, INSERM, Nantes, France; ²Université de Nantes, Nantes, France; ³ITUN, CHU de Nantes, Nantes, France; ⁴UMR892, INSERM, Nantes, France.
Background & Study Aim. We recently showed that an accumulation of highly differentiated TEMRA CD8 T cells in kidney transplant recipients with a stable graft…
2016 American Transplant Congress
Successful Transplantation in ABO- and HLA-Incompatible Kidney-Transplant Patients.
L. Rostaing, N. Congy, A. Allal, L. Esposito, F. Sallusto, N. Congy, X. Doumerc, B. Debiol, N. Kamar.
Néphrologie et Transplantation d'Organes, CHU Rangueil, Toulouse, France; INSERM U 563, CHU Purpan, Toulouse, France; Faculté de Médecine de Rangueil, Université Toulouse III Paul Sabatier, Toulouse, France; INSERM U1043 CNRS UMR 5282, CHU Purpan, Toulouse, France.
Introduction: ABO-incompatible (ABOi) and HLA-incompatible (HLAi) kidney transplantation using living donors is common place; however, few data have reported on the outcomes of ABOi/HLAi living-kidney…
2016 American Transplant Congress
Pre-Formed AT1R Antibodies Are Associated with Rejection After Kidney Transplantation.
D. Kim, P. Warner, K. Nelson, I. Gimferrer, C. Johnson, C. Blosser, R. Bakthavatsalam, N. Leca.
Nephrology, University of Washington, Seattle.
Antibody mediated injury is a significant contributor to rejection and allograft damage. Non-HLA antibodies have been increasingly recognized in association with graft dysfunction. Our goal…
2016 American Transplant Congress
The Impact of Allograft Rejection on DNA Methylation After Kidney Transplantation.
K. Boer, E. de Wit, D. Hesselink, L. Hofland, M. Betjes, C. Baan.
ErasmusMC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Introduction DNA methylation is a well-known epigenetic mechanism which plays a critical role in cell function by regulating gene expression. Variations in DNA methylation are…
2016 American Transplant Congress
Arteriolar Hyalinosis on Renal Transplant Protocol Biopsies Is Not Associated with Tacrolimus Exposure.
S. Yilmaz,¹ D. Shaffer,² Y. Qazi,³ F. Shihab,⁴ K. McCague,⁵ D. Patel,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Southern California, Los Angeles, CA; ⁴University of Utah, Salt Lake City, UT; ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁶University of California San Francisco, San Francisco, CA.
Previous studies have implicated the development of arteriolar hyalinosis (AH) following kidney transplantation to chronic calcineurin inhibitor nephrotoxicity. Here, we examined the association between tacrolimus…
2016 American Transplant Congress
Association Between Pretransplant Body Mass Index and Outcomes in Patients Undergoing Living Kidney Transplantation: A Consideration of Gender Differences.
M. Okumi,¹ K. Unagami,¹ M. Furusawa,¹ T. Hirai,¹ Y. Okabe,² K. Masutani,³ T. Shimizu,¹ K. Omoto,⁴ H. Ishida,¹ T. Kitazono,³ K. Tanabe,¹ The Japan Academic Consortium of Kidney Transplantation (JACK).
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Surgery, Kyusyu University, Fukuoka, Japan; ³Medicine and Clinical Science, Kyusyu University, Fukuoka, Japan; ⁴Urology, Todachuo General Hospital, Saitama, Japan.
[lsaquo]Background[rsaquo]There is epidemiologic evidence of an association between elevated body mass index (BMI), the progression of cardiovascular disease (CVD), and end-stage renal disease (ESRD). For…