Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Successful Treatment of Hepatitis C in Renal Transplant Recipients with Directly Acting Antiviral Agents.
M. Lubetzky,¹ S. Chun,¹ A. Joelson,¹ E. Akalin,¹ P. Gaglio,² G. DeBoccardo.¹
¹Transplantation, Albert Einstein College of Medicine, Bronx, NY; ²Hepatology, Columbia Universtiy, New York, NY.
Background: Hepatitis C infection (HCV) in kidney transplant (KTx) recipients has been shown to be a risk factor for decreased patient and allograft survival. With…
2016 American Transplant Congress
Relationship Between Mean Fluorescence Intensity and C1q/C3d-Fixing Capacities of Anti-HLA Antibodies.
G. Claisse,¹ L. Absi,² E. Alamartine,¹ N. Maillard,¹ C. Mariat.¹
¹Centre Hospitalier Universitaire - Hôpital Nord, Saint-Etienne, France; ²Laboratoire EFS Loire-Auvergne, Saint-Etienne, France.
The capacity of anti-HLA antibodies (Abs) to activate complement is thought to be an informative property susceptible to facilitate outcome prediction. Two different tests, C1q-…
2016 American Transplant Congress
Molecular Assessment of Kidney Transplant Biopsies Performs Similarly in Medulla and Cortex.
K. Madill-Thomsen,¹ J. Reeve,¹ G. Bohmig,² F. Eskandary,² P. Halloran.^1,3
¹Alberta Transplant Applied Genomics Center, Edmonton, AB, Canada; ²Department of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; ³Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada.
Histologic assessment of kidney biopsies is usually unable to interpret medulla, but molecular changes associated with rejection likely occur in both medulla and cortex. Analysis…
2016 American Transplant Congress
Many Discarded Kidneys Are Similar to Kidneys Accepted for Transplantation as Judged by Their Histologic Lesions and Molecular AKI Scores.
K. Famulski,¹ J. Reeve,¹ O. Aubert,² A. Loupy,² S. Niderhaus,³ J. Bromberg,³ P. Halloran.¹
¹University of Alberta, Edmonton, Canada; ²Necker Hospital, Paris, France; ³University of Maryland, Baltimore.
There is an increase in the number kidneys from older brain dead donors (DBD). Many are discarded based on conventional features (clinical or histology). Thus…
2016 American Transplant Congress
Standardized Pre-Implantation Kidney Biopsies of Expanded Criteria Donors to Improve the Kidney Donor Profile Index (KDPI) for the Evaluation of Marginal Donors.
A. Sánchez-Escuredo,¹ A. Sagasta,² F. Diekmann,¹ I. Revuelta,¹ L. Rodas,¹ D. Paredes,³ M. Musquera,⁴ N. Esforzado,¹ M. Ricart,¹ F. Cofan,¹ V. Torregrosa,¹ J. Campistol,¹ M. Sole,² F. Oppenheimer.¹
¹Nephrology and Renal Transplant, Hospital Clínic, Barcelona, Spain; ²Pathology, Hospital Clínic, Barcelona, Spain; ³Transplant Foundation, Hospital Clínic, Barcelona, Spain; ⁴Urology, Hospital Clínic, Barcelona, Spain.
There is no consensus of selection criteria used to allocate renal transplants from expanded criteria donors (ECD). The Kidney Donor Profile Index (KDPI) has been…
2016 American Transplant Congress
Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Dept. of Medicine, University of Alberta, Edmonton, AB, Canada; ²Dept. of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: CD16α mediates NK cell responses to donor-specific IgG antibodies (DSA), and shares mechanisms with effector T cell receptor (TCR) stimulation. Whether CD16α-inducible transcripts are…
2016 American Transplant Congress
Early Hospital Readmission Among Immunologically Vulnerable Kidney Transplantation Recipients.
E. King, B. Orandi, S. Bae, X. Luo, D. Segev.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: We previously established that 31% of all kidney transplant (KT) recipients experience early hospital readmission (EHR), or readmission within 30 days of discharge following…
2016 American Transplant Congress
Reduced Incidence of Rejection in AB0-incompatible Kidney Transplantation – Five Year Follow-Up in a Single Center.
A. Weidemann, F. Karpf, T. Dienemann, K. Birkner, J. Jacobi, K.-U. Eckardt.
Nephrology and Hypertension, Universitaet Erlangen-Nuernberg, Erlangen, Germany.
Introduction:Living kidney donation is the method of choice to expand the donor pool in times of severe organ shortage. In many centers, AB0-incompatible kidney transplantation…
2016 American Transplant Congress
Exposure Analysis for the Composite Efficacy Endpoints in the US92 Phase 3 Kidney Transplantation Trial to Understand Center Effects.
F. Shihab, B. Kaplan, K. McCague, D. Patel, F. Vincenti.
University of Utah, Salt Lake City; Mayo Clinic, Phoenix; Novartis Pharmaceuticals Corporation, East Hanover; University of California, San Francisco.
The US92 study determined whether, in de novo renal transplant patients, concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®, (mycophenolate…
2016 American Transplant Congress
Endoscopic Polydimethylsiloxane Injection in Prevention of Recurrent Graft Pyelonephritis for Transplanted Kidney with Vesicoureteral Reflux.
L. Nison,¹ M. Hazzan,² P. Puech,³ S. Bouye.¹
¹Urology, University of Lille, Lille, France; ²Nephrology, University of Lille, Lille, France; ³Radiology, University of Lille, Lille, France.
Reccurent acute graft pyelonephritis (AGPN) with vesicoureteral reflux (GVUR) can have a deleterious impact on graft outcome. The objective of this study was to evaluate…