Articles tagged "Kidney transplantation"

2017 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Quantifies and Differentiates Kidney Transplant Injury.
T. Sigdel,¹ J. Yang,¹ O. Bestard,² S.-C. Hsieh,¹ S. Roedder,² I. Damm,¹ J. Liberto,¹ S. Nandoe,¹ M. Sarwal.¹
¹University of California San Francisco, San Francisco; ²Immucor Inc, Atlanta
We sought to investigate the use of the common rejection module (CRM) genes in the discrimination of AR, BKVN, and stable transplant phenotypes in urine…
2017 American Transplant Congress
Lower Incidence of DSA-Induced Chronic Antibody-Mediated Rejection in Abo-Incompatible Renal Transplantation.
M. Okada,¹ Y. Watarai,¹ K. Iwasaki,² K. Futamura,¹ T. Hiramitsu,¹ M. Tsujita,¹ N. Goto,¹ S. Narumi,¹ T. Kobayashi.²
¹Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ²Transplant Surgery, Aichi Medical University, Nagakute, Japan
<INTRODUCTION>Current progress in immunosuppressive therapy has successfully controlled ABO-incompatibility in renal transplantation, although donor specific HLA antibody (DSA) is still insurmountable. Our in vitro experiments…
2017 American Transplant Congress
Assessment and Transplantation of Declined Human Kidneys Using Ex-Vivo Normothermic Kidney Perfusion.
S. Hosgood,¹ M. Hamed,¹ A. Sawpaul,² R. Figueiredo,² K. Saeb-Parsy,¹ C. Wilson,² M. Nicholson.¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Transplantation, Transplant Institute, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom
PurposeThe aim of this study was to make more kidneys available for transplantation by using ex-vivo normothermic kidney perfusion (EVKP) technology to assess the quality…
2017 American Transplant Congress
The Associations Between Body Mass Index and Kidney Transplant Outcomes Are Mediated by Weight-Adjusted Immunosuppression Dosing.
K. Flabouris,^1,2 S. Chadban,^1,3,4 M. Ladhani,^1,3,5 M. Cervelli,⁶ P. Clayton.^1,2,6
¹Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, Adelaide, Australia; ²School of Medicine, University of Adelaide, Adelaide, Australia; ³Sydney Medical School, University of Sydney, Sydney, Australia; ⁴Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ⁵Department of Renal Medicine, Lyell McEwin Hospital, Adelaide, Australia; ⁶Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia
Purpose: High body mass index (BMI) is associated with acute rejection after kidney transplantation. We hypothesised that weight-adjusted immunosuppression dosing is a contributing factor. We…
2017 American Transplant Congress
Inferior Graft and Patient Survival After Living Donor Renal Transplantation of Negatively Selected Right Kidneys.
S. Yamanaga,^1,2,3 A. Posselt,¹ C. Freise,¹ C. Niemann,¹ A. Rosario,¹ D. Fernandez,¹ T. Kobayashi,³ A. Ahearn,⁴ M. Tavakol,¹ S.-M. Kang.¹
¹Department of Surgery, UCSF, San Francisco, CA; ²Department of General Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan; ³Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; ⁴Department of Transplant Surgery, UMass Memorial Medical Center, Worcester, MA
Purpose: In living donor renal transplantation, the left kidney is usually chosen for anatomical reasons. The right kidney is sometimes chosen if it is believed…
2017 American Transplant Congress
Using Donors with False Positive HIV Tests – An Unexpected Benefit of the HOPE Act.
C. Durand,¹ S. Halpern,¹ G. Bismut,¹ B. Doby,¹ N. Desai,¹ A. Cameron,¹ S. Florman,² S. Lerner,² S. Huprikar,² J. Locke,³ S. Mehta,³ P. Stock,⁴ N. Neidlinger,⁵ D. Brown,¹ B. Haydel,² A. Redd,^1,6 A. Massie,¹ A. Tobian,¹ D. Segev.¹
¹JHU, Baltimore, MD; ²Mount Sinai, New York, NY; ³UAB, Birmingham, AL; ⁴UCSF, San Francisco, CA; ⁵Donor Network West, San Ramon, CA; ⁶NIH, Bethesda, MD
Deceased donors are screened for HIV infection using anti-HIV antibody (Ab) and nucleic acid testing (NAT). Historically, organs were discarded in cases of a suspected…
2017 American Transplant Congress
Cultural Competency of a Mobile, Customized Patient Education Tool for Improving Potential Kidney Transplant Recipients' Knowledge and Decision-Making.
D. Axelrod,¹ C. Kynard-Amerson,² D. Wojciechowski,³ K. Lentine,⁴ M. Schnitzler,⁴ J. Peipert,² A. Waterman.²
¹Surgery, East Carolina University, Greenville, NC; ²Medicine, UCLA, Los Angeles, CA; ³Medicine, Massachusetts General Hospital, Boston, MA; ⁴Transplant, Saint Louis University, St. Louis, MO
Patients with ESRD face a complex array of treatment options as a result of the revised kidney allocation system. Decision aids improve patient care through…
2017 American Transplant Congress
A Phase-Two, Randomised, Placebo-Controlled Trial: Belimumab in Renal Transplantation Targets Naïve, Activated Memory and Antibody Producing B Cells Whilst Sparing Regulatory B Cells.
G. Banham,^1,2 S. Flint,³ N. Torpey,² P. Lyons,¹ D. Shanahan,³ A. Gibson,³ A.-M. O'Sullivan,² R. Jones,^1,2,3 L. Devey,³ A. Richards,³ L. Erwig,³ C. Savage,³ K. Smith,^1,2 R. Henderson,³ M. Clatworthy.^1,2
¹Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; ²Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom; ³GlaxoSmithKline, Stevenage, United Kingdom
This phase 2, double-blind, randomised controlled study (BEL114424) explores the safety and potential efficacy of addition of belimumab to standard of care in renal transplantation…
2017 American Transplant Congress
Identification of Antibody-Mediated Rejection After Kidney Transplantation by Specific MicroRNAs.
M. Matz,¹ F. Heinrich,² P. Durek,² C. Lorkowski,¹ K. Wu,³ N. Lachmann,⁴ K. Budde,¹ M.-F. Mashreghi.²
¹University Medicine Charité-Nephrology, Berlin, Germany; ²German Rheumatism Research Centre DRFZ, Berlin, Germany; ³University Medicine Charité-Pathology, Berlin, Germany; ⁴University Medicine Charité-Transfusion Medicine, Berlin, Germany
Antibody-mediated rejection (ABMR) is the major cause for allograft failure, since a curative therapy is lacking. There are also still challenges in ABMR diagnosis. The…
2017 American Transplant Congress
Outcomes of 100 ABO Incompatible Kidney Transplants: A Single US Center Experience.
S. Sethi, A. Vo, E. Huang, L. Varanasi, J. Choi, A. Peng, R. Najjar, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
IntroductionAcceptable patient and graft outcomes of ABO incompatible (ABOi) living donor kidney transplantation (LDKT) have been reported with the use of desensitization strategies. Data on…