2017 American Transplant Congress
Single Kidney Transplantation from DCD Maastricht Category 3 Donors ≥ 60 Years: Is It Safe?
Aim. Compared to DBD, DCD kidneys show higher rates of primary non function (PNF), DGF, rejection, and premature transplant (Tx) loss. Some authors have advised…2017 American Transplant Congress
Evolution of Lipid Profile and Major Adverse Cardiac Events in Kidney Transplant Recipients Converted from Calcineurin Inhibitor to Everolimus: 24-Month Subanalysis from Elevate Study.
1ELEVATE Study Group, Berlin, Germany; 2Novartis Pharma AG, Basel, Switzerland
PURPOSE: Posttransplant (post-Tx) lipid abnormalities may increase risk of cardiovascular (CV) events in kidney transplant recipients (KTxR). Previous analysis from ELEVATE (NCT01114529) study confirmed that…2017 American Transplant Congress
Pre-Transplant HLA-Specific B Cell Breadth of Reactivity in a Novel Multiplex Bead-Based Assay Predicts Rejection in Kidney Transplant Recipients.
1Northwestern University, Chicago; 2Icahn School of Medicine at Mount Sinai, New York
Introduction: Recipients with broad sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) are at higher immunologic risk for poor graft…2017 American Transplant Congress
Proteomic Profiles of Deceased Donor Kidney Biopsies Obtained Prior to Transplantation Correlate with Allograft Function at One Year.
Introduction:Cerebral injury during Donation after Brain Death (DBD) will induce a systemic inflammatory response affecting immediate kidney function and survival posttransplantation. Assessment of donor organ…2017 American Transplant Congress
Utility of Weighted Composite Endpoints in Kidney Transplantation.
Cleveland Clinic, Cleveland, OH
IntroductionAdvances in therapeutic development and innovation are stifled in transplantation based on difficulties demonstrating efficacy of novel interventions using standard endpoints. Current RCTs are constrained…2017 American Transplant Congress
A Phase-Two, Randomised, Placebo-Controlled Trial: Belimumab in Renal Transplantation Targets Naïve, Activated Memory and Antibody Producing B Cells Whilst Sparing Regulatory B Cells.
This phase 2, double-blind, randomised controlled study (BEL114424) explores the safety and potential efficacy of addition of belimumab to standard of care in renal transplantation…2017 American Transplant Congress
Identification of Antibody-Mediated Rejection After Kidney Transplantation by Specific MicroRNAs.
Antibody-mediated rejection (ABMR) is the major cause for allograft failure, since a curative therapy is lacking. There are also still challenges in ABMR diagnosis. The…2017 American Transplant Congress
Outcomes of 100 ABO Incompatible Kidney Transplants: A Single US Center Experience.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
IntroductionAcceptable patient and graft outcomes of ABO incompatible (ABOi) living donor kidney transplantation (LDKT) have been reported with the use of desensitization strategies. Data on…2017 American Transplant Congress
Outcome of Kidney Transplantation from Deceased Octogenarian Donors.
Kidney and Pancreas Transplantation Uniti, Padua University Hospital, Padua, Italy
In order to expand the donor pool, the utilization of kidneys otherwise discarded because of extremely old age or comorbidities has been evaluated.We retrospectively analyzed…2017 American Transplant Congress
Plasma Extracellular Vesicles MicroRNA Signatures Associate with Graft Function Recovery Post-Acute Renal Allograft Injury.
Background: Early host-allograft cell-to-cell communications have been reported to occur via extracellular vesicles (EVs)/protein-miRNA complexes that might determine early allograft outcomes like delayed graft function…
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