Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Development of an M2 Macrophage Signature in Spontaneously Accepted Kidney Allografts
M. T. Guinn¹, E. S. Szuter¹, T. Yokose¹, J. Ge², B. Kwon¹, I. Rosales³, P. S. Russell¹, A. G. Cuenca², J. C. Madsen⁴, R. B. Colvin³, A. Alessandrini¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Boston Children's Hospital, Boston, MA, ³Department of Pathology, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁴Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted. We have recently shown that novel regulatory Tertiary Lymphoid…
2022 American Transplant Congress
Effectiveness of a Targeted Media Campaign on Engagement and Interest in Living Donation
L. A. Davis¹, A. Livingston², A. Waterman³
¹Houston Methodist Hospital, J.C. Walter Jr Transplant Center, Houston, TX, ²Multiview, Irving, TX, ³Transplant Research and Education Center, Houston, TX
*Purpose: Living donation rates have continued to decline. Research has suggested that disseminating living donation education and information more broadly to larger audiences outside of…
2022 American Transplant Congress
Ureteral Management for Kidney Transplantation in Patients with Ileal Conduit: Finger Technique
Y. Lin, M. Eltemamy, H. Kerr, V. Krishnamurthi, D. Goldfarb, A. Wee
Cleveland Clinic, Cleveland, OH
*Purpose: Kidney transplantation in patients with previous urinary diversion is a surgical challenge. In patients with ileal conduit, ureteral anastomosis is not standardized.*Methods: The technique…
2022 American Transplant Congress
Regulatory T Cells Suppress Memory IFN-Gamma Production in Highly Sensitised Patients
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitized patients (HS) present worse long-term outcome after transplantation compared to those without donor-specific antibodies (DSA). It has been suggested that desensitisation using…
2022 American Transplant Congress
Long Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Kidney Transplant Recipients
J. Leventhal¹, J. Galvin², J. Mathew³, L. Gallon³, D. Belshe⁴, M. Gibson⁴, K. Ravindra⁵, M. Horwitz⁶, S. Ildstad⁷
¹Feinberg School of Medicine, Northwestern University, Chicago, IL, ²University of Illinois Chicago, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁵Department of Surgery, Duke University Medical Center, Durham, NC, ⁶Adult Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC, ⁷Talaris Therapeutics Inc, Louisville, KY
*Purpose: 37 subjects were transplanted in a phase 2 protocol based upon tolerogenic CD8+/TCR-facilitating cells (FCR001) to induce tolerance in recipients of living donor kidney…
2022 American Transplant Congress
Utility of a Holistic Molecular Paradigm for Kidney Biopsy in the Clinic
S. Anand¹, J. Sanchez-Garcia¹, K. Qui², K. Pinney², A. Raza¹, T. Srinivas², D. Morris¹
¹Intermountain Medical Center, Murray, UT, ²CareDX, South San Francisco, CA
*Purpose: We report on the clinical utility of a serial dd-cfDNA (donor derived cell free DNA) monitoring coupled with Tissue Transcriptomics (Tr) and Histology (Hx)…
2022 American Transplant Congress
Association of Psychosocial Clearance and Race in the Kidney Transplant Evaluation Process
V. S. Valbuena¹, C. Satarino², M. S. Anderson¹, J. Obayemi¹, T. J. Iwashyna³, R. Sung¹
¹Department of Surgery, University of Michigan, Ann Arbor, MI, ²Department of Social Work, University of Michigan, Ann Arbor, MI, ³Department of Internal Medicine, University of Michigan, Ann Arbor, MI
*Purpose: The psychosocial evaluation of transplant candidates is a comprehensive assessment of the (Fig 1). Psychosocial risk factors can be the only basis for not…
2022 American Transplant Congress
Evaluation of Hepatitis C Positive Donor to Hepatitis C Negative Recipient Kidney Transplant in a Highly Sensitized Patient Population
A. T. Iaria, M. Martin, A. Hietpas, I. Tang, S. Koppe, I. Tzvetanov, E. Benedetti, C. Muran
University of Illinois at Chicago, Chicago, IL
*Purpose: This study assessed outcomes of hepatitis C virus (HCV) donor positive to recipient negative (D+/R-) kidney transplants (KT) in high immunologic risk patients. Literature…
2022 American Transplant Congress
Histologic Borderline Reflects Molecular Injury Not Rejection: Results from the Trifecta Study
P. F. Halloran¹, K. S. Madill-Thomsen¹, Z. Demko², A. Prewett², P. Billings², P. Gauthier², .. and the Trifecta Investigators³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Natera Inc., San Carlos, CA, ³., ., AB, Canada
*Purpose: In the Trifecta study (NCT04239703), we recently compared indication biopsy diagnoses (MMDx and histology) and plasma %dd-cfDNA levels for indication biopsies (JASN in press…
2022 American Transplant Congress
Implementation of Infectious Disease Surveillance in Recently Deceased Human Xenograft Study
S. J. Cawthon, E. P. Weldon, N. S. Lawson, B. E. Lonze, R. A. Montgomery, S. A. Mehta
NYU Langone Transplant Institute, New York, NY
*Purpose: Xenotransplantation is a promising solution for the ongoing organ shortage but has been slow to develop because of both immunological challenges and potential risk…