Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.
W. Zhang,¹ Z. Yi,¹ E. Stahl,² M. Menon,¹ K. Keung,³ K. Hao,² P. O'Connell,³ B. Murphy.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ²Department of Genetics and Genomic Science, Ichan School of Medicine at Mount Sinai, New York, NY; ³Renal Unit, University of Sydney at Westmead Hospital, Sydney, Australia
Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
2017 American Transplant Congress
Down but Not Out: Leucopenia Can Be Safely Treated with Reduction in Immunosuppression without Increasing Risk to the Kidney Allograft.
A. Gilbert,¹ A. Vergottini,¹ A. Karabala,¹ M. Grafals,¹ B. Javaid,¹ J. Moore,¹ J. Verbesey,² P. Abrams,² S. Ghasemian,² M. Cooper.²
¹Department of Medicine, Medstar Georgetown Transplant Institute, Washington, DC; ²Department of Surgery, Medstar Georgetown Transplant Institute, Washington, DC
IntroductionLeucopenia is a growing problem with increasing immunosuppression (IS) in kidney transplantation. Reducing IS in the face of leucopenia is a concern due to the…
2017 American Transplant Congress
Outcome of Adult Living Donor Renal Transplants in Different Era: Analysis of UNOS Database.
V. Whittaker, R. Gruessner, M. Laftavi, Z. Acun, A. Gruessner.
Surgery, State University New York, Syracuse, NY
Background:Living donation is the potential solution to increasing donor donor shortage. This retrospective analysis of UNOS database analyses the outcome of living donor transplantation across…
2017 American Transplant Congress
Lack of Specificity of LC-MS/MS Based Urinary Biomarkers for Polyomavirus BK Nephropathy (BKPyVN).
G. Zeng,¹ L. Pan,² Z. Lyu,² Y. Huang,¹ P. Randhawa.¹
¹Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; ²Departments of Nephrology & Pathology, Guangxi Medical University, Nanning, Guangxi, China
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) based studies have suggested that BKPyVN leads to the excretion of virus-specific urinary peptides which can serve as diagnostic markers…
2017 American Transplant Congress
TGF-β1 Induces Transplant Kidney Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition via TGF-β/Smad and Akt/mTOR/p70S6K Pathways.
Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Chronic allograft dysfunction (CAD) induced by kidney interstitial fibrosis is the main cause of allograft failure in kidney transplantation. Studies suggested that endothelial-to-mesenchymal transition…
2017 American Transplant Congress
Prospective Monitoring of De Novo Donor-Specific Antibodies: Incidence, Clinical Outcomes and Dynamic Changes Over 5 Years After Kidney Transplantation.
M. Ajaimy, A. Colovai, N. Hayde, J. Graham, M. Lubetzky, L. Kamal, G. De Bocardo, E. Akalin.
Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx
Background: We aimed to investigate the incidence and dynamic changes of de novo donor-specific-antibodies (dnDSA) after kidney transplantation and clinical outcomes.Methods: This is a prospective…
2017 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Improves Function of Extreme Marginal Renal Grafts Subjected to Prolonged Ischemia.
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ C. Cassol,² R. John,² P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,³ D. Grant,¹ L. Robinson,⁴ M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Laboratory Medicine and Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ³Departments of Surgery (Urology) and Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁴Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
Background: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could promote improved marginal graft function compared…
2017 American Transplant Congress
Significance of Thrombotic Microangiopathy in Renal Allografts.
B. Ozdemir,¹ A. Ok Atilgan,¹ M. Haberal.²
¹Pathology, Baskent University, Ankara, Turkey; ²Transplant Surgery, Baskent University, Ankara, Turkey
Thrombotic microangiopathy (TMA) in the renal allograft is a form of renal capillary injury that may associate with many disorders including calcineurin inhibitor (CI) toxicity,…
2017 American Transplant Congress
A Comparison of Medical Costs Among ABO-Compatible, -Incompatible, and -Minor Mismatched Living Kidney Transplantation: A Single-Center Study.
D. Fujimori, M. Okumi, K. Ungami, H. Ishida, K. Tanabe.
Urology, Tokyo Women's Medical University, Tokyo, Japan
[Background]ABO-incompatible living kidney transplantation (ABO-ILKT) is considered an effective alternative to deceased kidney transplantation. Although ABO-ILKT required extra strategies and suffered extra risks across ABO…
2017 American Transplant Congress
Effects of Anti-HLA Antibodies on Endothelial Expression and Serum Levels of Thrombomodulin in Kidney Recipients.
S. Beland, O. Desy, P. Valin, S. De Serres.
Medicine, Universite Laval, Quebec, QC, Canada
Background: Thrombomodulin (TBM) is an anticoagulant and anti-inflammatory protein expressed on endothelial cells (ECs). Mutations of TBM are seen in thrombotic microangiopathies due to aHUS.…