Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Eight Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.
J. Leventhal,¹ J. Galvin,¹ J. Mathew,¹ L. Gallon,¹ D. Stare,¹ A. Sweeney,¹ J. Miller,¹ M. Abecassis,¹ S. Ildstad.²
¹Northwestern University, Chicago; ²U of Louisville, Louisville
36 subjects have been transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts (KTx). The protocol…
2017 American Transplant Congress
Impact of Cold Ischemia Time on Outcomes in Kidney Paired Donation (KPD).
R. Redfield,¹ D. Vock,² R. Hayes,¹ A. Matas.²
¹UWHealth, Madison; ²UMN, Minneapolis
Cold ischemic time (CIT) is an established risk factor for delayed graft function (DGF) in DD kidney tx. Impact of prolonged CIT, in the context…
2017 American Transplant Congress
Composite Prognostic Score Improves Clinical Benefit in Kidney Recipients Receiving Standard of Care Therapy for Antibody-Mediated Rejection.
D. Viglietti, A. Loupy, O. Aubert, E. Pillebout, C. Legendre, D. Glotz, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France
There is a marked heterogeneity in AMR patients' prognosis after SOC treatment including plasma exchange (PE) and intravenous immunoglobulins (IVIG). We investigated whether the use…
2017 American Transplant Congress
A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.
M. Xu,¹ B. Banan,¹ X. Wang,¹ D. Chirumbole,¹ B. Rabe,¹ S. Garcia-Aroz,¹ D. Nayak,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ J. Gaut,² P. Manning,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Washington University School of Medicine, St. Louis; ²Department of Pathology and Immunology, Washington University School of Medicine, St. Louis; ³Tioma Therapeutics, Inc, St. Louis
PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…
2017 American Transplant Congress
Neutropenia in Kidney Transplantation: A Hidden Threat to Graft Survival.
A. Vergottini, A. Karabala, P. Abrams, J. Verbesey, S. Ghasemian, J. Moore, M. Grafals, B. Javaid, M. Cooper, A. Gilbert.
Medstar Georgetown Transplant Institute, Washington, DC
IntroductionNeutropenia is a common complication after kidney transplantation resulting in a reduction of immunosuppression and the use of granulocyte colony-stimulating factors (G-CSF) which can increase…
2017 American Transplant Congress
Early Evolution and Immunopathologic Phenotype of Treg-Rich Organized Lymphoid Structures (TOLS) Associated with Immunological Tolerance in Accepted Mouse Kidney Allografts.
C. Yang,¹ I. Rosales,² E. Farkash,³ D. Ndishabandi,^1,3 R. White,³ P. Russell,¹ J. Madsen,¹ A. Alessandrini,^1,3 R. Colvin.^1,3
¹Center for Transplantation Sciences, Mass General Hospital, Boston, MA; ²Department of Pathology, Mass General Hospital, Boston, MA; ³Department of Pathology, University of Michigan, Ann Arbor, MI
Introduction: Lymphoid neogenesis has been found in allografts after organ transplant. We previously reported that spontaneously accepted DBA/2 to B6 kidney allografts developed distinctive, peri-arterial…
2017 American Transplant Congress
Procurement Kidney Biopsy versus KDRI for Predicting Graft Survival.
I. Hall,¹ C. Parikh,² B. Schröppel,³ F. Weng,⁴ Y. Jia,² H. Thiessen-Philbrook,² P. Reese,⁵ M. Doshi.⁶
¹University of Utah, Salt Lake City, UT; ²Yale University, New Haven, CT; ³University Hospital, Ulm, Germany; ⁴Saint Barnabas Medical Center, Livingston, NJ; ⁵University of Pennsylvania, Philadelphia, PA; ⁶Wayne State University, Detroit, MI
Background: The kidney donor risk index (KDRI) incorporates 10 variables to match organ quality with expected recipient survival. Though controversial, procurement biopsies are often performed…
2017 American Transplant Congress
Donation After Circulatory Death (DCD) Kidneys Are More Likely to Be Discarded than Kidneys from Neurologically Brain Dead Donors (NBD).
J. Gill,¹ C. Rose,¹ J. Lesage,¹ Y. Joffres,¹ J. Gill,¹ K. O'Connor.²
¹UBC, Vancouver, Canada; ²LifeCenter, Seattle
Strategies to decrease organ discard are needed. We determined the adj odds of discard of DCD vs NBD kidneys in kidney donor profile index (KDPI)…
2017 American Transplant Congress
Nephrectomy of the Failed First Kidney Allograft Predisposes Kidney Transplant Recipients to Presensitization with Alloreactive T-Cells and Inferior Allograft Survival After Retransplantation.
T. Schachtner,^1,2 M. Stein,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany
During the last two decades the number of recipients (KTRs) of a previous kidney transplantation being evaluated and waitlisted for a subsequent kidney transplantation has…
2017 American Transplant Congress
Complement Binding Activity (C3d, C1q) of De Novo Donor-Specific HLA Antibody Is Associated with Increased Risk of Antibody-Mediated Rejection in Non-Sensitized Kidney Transplant Recipients.
H. Lee,¹ E. Han,¹ A.-R. Choi,¹ K. Park,² J. Ryu,² B. Chung,³ C. Yang,³ E.-J. Oh.¹
¹Laboratory Medicine, The Catholic University of Korea, Seoul, South Korea (KOR), Korea; ²Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, South Korea (KOR), Korea; ³Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea (KOR), Korea
Despite advances in therapeutic strategies and medicine, antibody mediated rejection (AMR) is a leading cause of kidney graft loss. The complement binding activity of donor-specific…