2017 American Transplant Congress
A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.
PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…2017 American Transplant Congress
Neutropenia in Kidney Transplantation: A Hidden Threat to Graft Survival.
Medstar Georgetown Transplant Institute, Washington, DC
IntroductionNeutropenia is a common complication after kidney transplantation resulting in a reduction of immunosuppression and the use of granulocyte colony-stimulating factors (G-CSF) which can increase…2017 American Transplant Congress
Early Evolution and Immunopathologic Phenotype of Treg-Rich Organized Lymphoid Structures (TOLS) Associated with Immunological Tolerance in Accepted Mouse Kidney Allografts.
Introduction: Lymphoid neogenesis has been found in allografts after organ transplant. We previously reported that spontaneously accepted DBA/2 to B6 kidney allografts developed distinctive, peri-arterial…2017 American Transplant Congress
Procurement Kidney Biopsy versus KDRI for Predicting Graft Survival.
Background: The kidney donor risk index (KDRI) incorporates 10 variables to match organ quality with expected recipient survival. Though controversial, procurement biopsies are often performed…2017 American Transplant Congress
Donation After Circulatory Death (DCD) Kidneys Are More Likely to Be Discarded than Kidneys from Neurologically Brain Dead Donors (NBD).
1UBC, Vancouver, Canada; 2LifeCenter, Seattle
Strategies to decrease organ discard are needed. We determined the adj odds of discard of DCD vs NBD kidneys in kidney donor profile index (KDPI)…2017 American Transplant Congress
Nephrectomy of the Failed First Kidney Allograft Predisposes Kidney Transplant Recipients to Presensitization with Alloreactive T-Cells and Inferior Allograft Survival After Retransplantation.
During the last two decades the number of recipients (KTRs) of a previous kidney transplantation being evaluated and waitlisted for a subsequent kidney transplantation has…2017 American Transplant Congress
Complement Binding Activity (C3d, C1q) of De Novo Donor-Specific HLA Antibody Is Associated with Increased Risk of Antibody-Mediated Rejection in Non-Sensitized Kidney Transplant Recipients.
Despite advances in therapeutic strategies and medicine, antibody mediated rejection (AMR) is a leading cause of kidney graft loss. The complement binding activity of donor-specific…2017 American Transplant Congress
Naïve and Interferon-gamma Activated Mesenchymal Stem Cells Differentially Affect Immune Responses In Vitro and In Vivo.
We have observed interferon gamma-treated autologous mesenchymal stem cells (MSC) to rapidly ex vivo expand CD3+CD4+CD25- T cells to >80% CD3+CD4+C25+FoxP3+ T regulatory cells with…2017 American Transplant Congress
A Multistate Modeling Analysis of Time-Varying CPRA States and Its Impact on Kidney Transplant: A Focus on KAS Implementation.
Background: Highly sensitized kidney transplant candidates are at higher risk of death on the waiting list(WL). OPTN policy change 8(Kidney Allocation System(KAS)) aimed to improve…2017 American Transplant Congress
Zero-Time Biopsy of Potential Donor Kidneys to Aid Decision-Making: A 9-Year Single-Center Experience.
Necker-Enfants Malades, Tenon and European Georges Pompidou Hospitals, Paris, France
The added benefits of zero-time biopsy of a potential donor kidney on top of standard donor biological and clinical data to aid in the decision…
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