ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Kidney transplantation"

  • 2017 American Transplant Congress

    Efficacy and Safety of Everolimus with Reduced-Exposure Tacrolimus and Corticosteroid Withdrawal in De Novo Pediatric Renal Transplant Recipients: 12-Month Results from the CRADLE Study.

    R. Ettenger,1 B. Tönshoff,1 H. Tedesco,1 L. Dello Strologo,1 S. Marks,1 L. Pape,1 E. Martzloff,2 B. Rauer,2 J. Ng,3 P. Lopez.2

    1A2314 Study Group, Los Angeles; 2Novartis Pharma AG, Basel, Switzerland; 3Novartis Pharmaceutical Corporation, East Hanover

    PURPOSE: We present 12-month (M) results from the CRADLE study (NCT01544491) that assessed efficacy and safety of everolimus (EVR) with reduced-exposure tacrolimus (rTAC) and early…
  • 2017 American Transplant Congress

    Gene Expression Signature of Subclinical Allograft Kidney ABMR Compared to Clinical ABMR.

    O. Aubert,1 C. Lefaucheur,1 S. Higgins,1 L. Hidalgo,2 J. Duong Van Huyen,1 D. Viglietti,1 X. Jouven,1 D. Glotz,1 C. Legendre,1 P. Halloran,2 A. Loupy.1

    1Paris Translational Research Center for Organ Transplantation, Paris, France; 2ATAGC, Edmonton, France

    BackgroundAntibody-mediated rejection (ABMR) is characterized by a heterogeneous presentation. It occurs in clinically stable patients (sABMR) or in patients with allograft dysfunction (ABMR), but only…
  • 2017 American Transplant Congress

    Complement Markers in Immunoadsorption Combined with Membrane Filtration.

    P. Malvezzi,1 F. Defendi,2 F. Eskandary,3 T. Jouve,1 L. Rostaing,1 C. Dumestre-Perard,2 G. Böhmig.3

    1Clinique de Néphrologie, CHUGA, Grenoble, France; 2Laboratoire d'Immunologie, CHUGA, Grenoble, France; 3Department of Medicine III, Medical University, Vienna, Austria

    Introduction: In HLA incompatible transplantation pretransplant desensitization is mandatory in order to eliminate the donor-specific alloantibody that might fix complement (C). In a randomized crossover…
  • 2017 American Transplant Congress

    The Use of Kidneys from Deceased Donors Over 80 Years in Kidney Transplantation.

    M. Pérez-Sáez,1 E. Arcos,2 J. Comas,2 J. Pascual.1

    1Nephrology, Hospital del Mar, Barcelona, Spain; 2Organització Catalana de Trasplantaments, Barcelona, Spain

    Patient survival is longer after kidney transplantation (KT) compared with remaining in the waiting list on dialysis. We have questioned if this is true also…
  • 2017 American Transplant Congress

    The Role of Urinary Chemokines in Distinguishing Causes of Renal Allograft Dysfunction.

    S. Chong,1 R. Fernando,2 M. Harber,1 C. Magee.1

    1UCL Centre for Nephrology, Royal Free Hospital, London, United Kingdom; 2Anthony Nolan Laboratories, Royal Free Hospital, London, United Kingdom

    The aetiology of renal transplant dysfunction is varied, and diagnosis often relies upon transplant biopsy, an invasive procedure that carries significant risk. Availability of a…
  • 2017 American Transplant Congress

    Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.

    W. Zhang,1 Z. Yi,1 E. Stahl,2 M. Menon,1 K. Keung,3 K. Hao,2 P. O'Connell,3 B. Murphy.1

    1Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; 2Department of Genetics and Genomic Science, Ichan School of Medicine at Mount Sinai, New York, NY; 3Renal Unit, University of Sydney at Westmead Hospital, Sydney, Australia

    Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
  • 2017 American Transplant Congress

    Down but Not Out: Leucopenia Can Be Safely Treated with Reduction in Immunosuppression without Increasing Risk to the Kidney Allograft.

    A. Gilbert,1 A. Vergottini,1 A. Karabala,1 M. Grafals,1 B. Javaid,1 J. Moore,1 J. Verbesey,2 P. Abrams,2 S. Ghasemian,2 M. Cooper.2

    1Department of Medicine, Medstar Georgetown Transplant Institute, Washington, DC; 2Department of Surgery, Medstar Georgetown Transplant Institute, Washington, DC

    IntroductionLeucopenia is a growing problem with increasing immunosuppression (IS) in kidney transplantation. Reducing IS in the face of leucopenia is a concern due to the…
  • 2017 American Transplant Congress

    Outcome of Adult Living Donor Renal Transplants in Different Era: Analysis of UNOS Database.

    V. Whittaker, R. Gruessner, M. Laftavi, Z. Acun, A. Gruessner.

    Surgery, State University New York, Syracuse, NY

    Background:Living donation is the potential solution to increasing donor donor shortage. This retrospective analysis of UNOS database analyses the outcome of living donor transplantation across…
  • 2017 American Transplant Congress

    Lack of Specificity of LC-MS/MS Based Urinary Biomarkers for Polyomavirus BK Nephropathy (BKPyVN).

    G. Zeng,1 L. Pan,2 Z. Lyu,2 Y. Huang,1 P. Randhawa.1

    1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Departments of Nephrology & Pathology, Guangxi Medical University, Nanning, Guangxi, China

    Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) based studies have suggested that BKPyVN leads to the excretion of virus-specific urinary peptides which can serve as diagnostic markers…
  • 2017 American Transplant Congress

    Mechanisms of Fibrosis in the Allograft Kidney: RNA-seq Based Analysis Using Formalin Fixed Biopsies.

    G. Zeng,2 L. Pan,1 Z. Lyu,1 Y. Huang,2 P. Randhawa.2

    1Department of Nephrology, Guangxi Medical University, Nanning, Guangxi, China; 2Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    Development of allograft fibrosis determines long term graft survival but our understanding of this important complication is incomplete. To gain further insight into this problem…
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