Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Prevalence of CYP3A Genomic Variances and Impact on Tacrolimus Dosing Requirements in Kidney Transplant Recipients in Eastern North Carolina.
T. Asempa,¹ S. Hudson,² L. Rebellato,² A. Maldonado.¹
¹Vidant Medical Center, Greenville, NC; ²East Carolina University, Greenville, NC
BACKGROUND: African American (AA) patients are substantially more likely to express CYP3A5. Presence of CYP3A5 polymorphisms is an important pharmacotherapeutic consideration due to the extensive…
2017 American Transplant Congress
Steroid Free Maintenance Immunosupression in Kidney Transplantation: Indiana University Experience.
S. Hussain, T. Taber, A. Sharfuddin, M. Yaqub, W. Goggins, D. Mishler, O. Adebiyi.
Renal Transplant, Indiana University School of Medicine, Indianapolis, IN
Background: Steroid based maintenance Immunosuppression (IS) regimen is the standard protocol for many kidney transplant(tx) centers. However, concerns for chronic steroid impact on patients remains…
2017 American Transplant Congress
Detection of Shared and Distinct Gene Expression Signatures in Tissue and Urine During Acute Rejection of Kidney Grafts.
K. Keslar,¹ A. Zmijewska,² J. Chen,² K. Newell,³ P. Heeger,⁴ R. Mannon,² R. Fairchild.¹
¹Department of Immunology, Cleveland Clinic, Cleveland, OH; ²Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Department of Surgery, Emory University, Atlanta, GA; ⁴Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY
A major goal of the Clinical Trials in Organ Transplantation (CTOT) studies is the identification of biomarkers that predict or diagnose acute graft rejection in…
2017 American Transplant Congress
Pulse Pressure After Renal Transplantation – Influence on Outcome: Results from the Collaborative Transplant Study.
B. Krüger,¹ B. Döhler,² B. Krämer,¹ C. Süsal.²
¹V. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Baden-Württemberg, Germany; ²Institut für Immunologie, Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg, Germany
Systolic blood pressure (SBP) and diastolic blood pressure (DBP) are important predictors of graft and patient survival in renal transplant recipients. Pulse pressure (PP), the…
2017 American Transplant Congress
Pediatric Recipients of Deceased Adult Donor Kidneys Have Equivalent Outcomes Compared with Pediatric Donors.
D. Mikhail,¹ H. Sharma,^3,4 J. Chen,² M. Cooper,⁴ A. Sener,^1,3 P. Luke.^1,3
¹Urology, Western University, London, ON, Canada; ²Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Multi-Organ Transplant Surgery, Western University, London, ON, Canada; ⁴Transplant Surgery, Georgetown University, Washington, DC
INTRODUCTION:Efforts are made to transplant paediatric deceased donor kidneys into pediatric recipients. To our knowledge, data does not support better graft outcomes with matched pediatric…
2017 American Transplant Congress
Optimizing Support for Living Kidney Donors: Insights from a Prospective Study.
D. Dobosz,¹ C. Thiessen,¹ S. Li,¹ K. Yu,¹ J. Gannon,¹ K. Kennedy,³ D. Gray,² A. Mussell,² P. Reese,² E. Gordon,³ S. Kulkarni.¹
¹Yale U, New Haven; ²U Pennsylvania, Philadelphia; ³Northwestern U, Chicago
PurposeTo assess how potential living kidney donors (LKDs) perceived support from the transplant team and areas for improvement.MethodsWe conducted a prospective, longitudinal study of individuals…
2017 American Transplant Congress
Predictors of Graft Loss in an Urban Predominantly Minority Cohort of Kidney Transplant Recipients.
N. Hayde, L. Kamal, M. Ajaimy, M. Lubetzky, P. Bedi, G. de Boccardo, E. Akalin.
Monterfiore/Einstein Center for Transplantation, Bronx, NY
BackgroundWe aimed to determine the demographic and clinical characteristics associated with graft loss in a cohort of kidney transplant recipients with a high African-American and…
2017 American Transplant Congress
Transplantation of Hepatitis C Kidneys to Hepatitis C Recipients Confers Significantly Shorter Waiting Times in the Era of the New Kidney Allocation System.
B. Concepcion, A. Langone, B. Edmundson, J. Johnson, A. Rajput, T. Johnson, D. Rybacki, D. Hale, R. Forbes.
Nashville VA Medical Center, Nashville, TN
Background: Prior to the new KAS, transplantation with HCV+ compared to HCV- kidneys provided shorter waiting times on the deceased donor list. In the current…
2017 American Transplant Congress
Manning the Gap: Using Technology to Reduce Barriers in Access to Renal Transplantation Waiting List Across Dialysis Facilities.
G. Ferreira,¹ K. Bastos,² E. Barbeta,² B. Pereira,² G. Souza,¹ M. de Souza,¹ V. Colares.¹
¹Kideny Transplant UPI, Santa Casa de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil; ²Nephrology, CTDR, Juiz de Fora, Minas Gerais, Brazil
Background:Pervasive disparities in access to kidney transplantation persist despite decades of recognition and efforts to improve equity in transplant access. Using technology to reduce the…
2017 American Transplant Congress
De Novo, Non-Donor Specific HLA Antibodies Are Associated with Inferior Allograft Outcomes After Kidney and Simultaneous Kidney-Pancreas Transplantation.
S. Hassan,¹ G. Lucisano,¹ E. Santos,² D. McKeown,³ D. Goodall,¹ A. Gueret-Wardle,¹ A. McLean,¹ P. Brooks,² M. Willicombe,¹ D. Taube.¹
¹Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom; ³Blood Transfusion, Imperial College Healthcare NHS Trust, London, United Kingdom
Introduction: Donor specific antibodies [DSAs] occurring after transplantation are associated with poorer outcomes. However the significance of non-donor directed HLA antibodies [ndHLAs] after transplantation in…