Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Successful Utilization of Deceased Donor Kidney Allografts with KDPI>85: A Single Center Experience.
A. Agarwal, W. Ally, K. Brayman.
University of Virginia, Charlottesville, VA
In December 2014, UNOS implemented broad changes in the new Kidney Allocation System (KAS). Recent UNOS summary reports suggest that nationally, organ discard rates have…
2017 American Transplant Congress
Validation of a Novel Computational Approach for Predicting HLA Immunogenicity Based on Quantification of Structural and Surface Electrostatic Potential Differences Between Donor and Recipient HLA.
V. Kosmoliaptsis,¹ C. Kling,² M. Robb,³ D. Collett,³ J. Bradley,¹ C. Taylor,¹ D. Kabelitz,² D. Mallon.¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²University of Kiel, Kiel, Germany; ³NHS Blood and Transplant, Bristol, United Kingdom
Background: Our preliminary work indicates that donor HLA immunogenicity in kidney and haematopoietic stem cell transplantation can be predicted by comparative assessment of donor and…
2017 American Transplant Congress
Impact of Cytokine Gene Polymorphism on Clinical Outcome of Renal Transplantation.
I. Pérez-Flores,¹ J. Santiago,² A. Moreno Dela Higuera,¹ N. Calvo,¹ B. Rodriguez-Cubillo,¹ E. Urcelay,² A. Shabaka,¹ M. Calvo,¹ A. Sanchez-Fructuoso.¹
¹Nephrologist, Hospital Clinico San Carlos, Madrid, Spain; ²UGC Immunology, Hospital Clinico San Carlos and Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain
Cytokine production is subject to genetic regulation, in such a way that gene polymorphisms at the level of promoter or coding regions can alter their…
2017 American Transplant Congress
Cost Effectiveness of Post-Prophylaxis Screening Strategies for Cytomegalovirus Viremia in CMV D+R- Kidney Transplant Recipients.
C. Puttarajappa,¹ S. Hariharan,¹ K. Smith.²
¹Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA; ²Section of Decision Sciences, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
Purpose: To assess cost-effectiveness(CE) of screening for CMV after 6 months of valganciclovir prophylaxis in CMV high-risk (D+R-) kidney transplant recipients.Methods: A Markov model was…
2017 American Transplant Congress
Impact of Race on Selection of the Living Donor Candidate.
D. Bohorquez, A. Thomasson, P. Porrett.
Surgery, University of Pennsylvania, Philadelphia, PA
Background It has been reported that African-Americans (AA) living kidney donors have an increased risk of ESRD versus non-Hispanic whites (NHW). To date, it is…
2017 American Transplant Congress
Immediate vs Delayed Initiation of CMV Prophylaxis…Safe and Cost Beneficial?
L. Cotiguala, A. Carlson, C. Truax, B. Sirandas, I. Hall, L. Smith.
University of Utah Health Care, Salt Lake City, UT
Background: Recommendations differ on when to initiate valganciclovir (VGCV) for CMV prophylaxis (ppx) after tx. Current labeling states within 10 days of tx. We evaluated…
2017 American Transplant Congress
RAS Inhibition Attenuates Urine Angiotensin II-Regulated Proteins Associated with Interstitial Fibrosis and Tubular Atrophy in Kidney Transplant Recipients.
Z. Mohammed-Ali,¹ S. Reid,³ P. Yip,¹ H. Cardinal,² M.-J. Hébert,² Y. Li,⁴ S. Kim,^1,3,4 A. Konvalinka.^1,3
¹University Health Network, Toronto, ON, Canada; ²Centre de Recherche du Centre Hospitalier de l'Université de Montréal - CRCHUM, Montréal, QC, Canada; ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁴Institute of Health Policy, University of Toronto, Toronto, ON, Canada
Angiotensin-II (AngII), the main effector of the renin-angiotensin system (RAS), can lead to interstitial fibrosis/ tubular atrophy (IFTA) in kidney transplant recipients, mainly through AT-1R…
2017 American Transplant Congress
Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.
A. Colovai, M. Ajaimi, N. Hayde, L. Kamal, S. Chan, C. Savchik, J. Rocca, E. Akalin.
Surgery, Montefiore Medical Center, Bronx, NY
The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…
2017 American Transplant Congress
Extended Ex Vivo Kidney Perfusion Using Hemopure as an Oxygen Carrier: A Method to Preserve, Assess and Repair Discarded Organs.
F. Fontan, M. Aburawi, N. Karimian, K. Uygun, F. Delmonico, H. Yeh, J. Markmann.
Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background: Hypothermic non-oxygenated machine perfusion (HMP) is commonly used in kidney preservation, providing some advantage over static cold storage, as well as flow and resistance…
2017 American Transplant Congress
Recurrent Lupus Nephritis in a Multi-Ethnic Kidney Transplant Population.
I. Tang,¹ A. Koganti,¹ S. Setty,² S. Akkina.³
¹Medicine, University of Illinois at Chicago, Chicago, IL; ²Pahology, University of Illinois at Chicago, Chicago, IL; ³Medicine, Loyola University, Chicago, IL
The incidence of recurrent lupus nephritis varies among different ethnic groups. We performed a single center retrospective analysis of recurrent lupus nephritis in kidney transplant…