2017 American Transplant Congress
Urinary Type III Procollagen (PIIINP) Is Associated with Chronic Allograft Dysfunction and Predicts Graft Survival.
Background: Chronic allograft dysfunction (CAD) is the most important clinical problem in solid organ transplantation. Interstitial fibrosis and tubular atrophy contribute to long term renal…2017 American Transplant Congress
Potential Living Kidney Donors (LKD) Concerns About Opting Out and Preferences for an 'Alibi'.
1Yale U, New Haven; 2Northwestern U, Chicago; 3U Pennyslvania, Philadelphia
PurposeTo evaluate potential LKDs comfort discussing opting out with their intended recipient (IR) and preferences for alibisMethodsWe conducted a prospective, longitudinal study of potential LKDs…2017 American Transplant Congress
A Novel KPD Mechanism to Increase Transplants When Some Candidates Have Multiple Willing Donors.
1Carnegie Mellon U, Pittsburgh; 2U of Maryland, College Park; 3UNOS, Richmond; 4Yale U, New Haven
Purpose: Current kidney exchanges such as the OPTN Kidney Paired Donation (KPD) program allow candidates to list multiple willing donors, but only one will donate…2017 American Transplant Congress
Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients [THINKER] Trial.
University of Pennsylvania, Philadelphia
Background: More than 500 kidneys from HCV+ deceased donors are discarded each year, even though direct acting antiviral therapies have cure rates exceeding 95%. We…2017 American Transplant Congress
Blood Transfusion Induced Donor Specific Antibodies Are Associated with Rejection and Graft Failure.
Introduction: Although it is well known that blood transfusions post-transplant are associated with the development of both HLA and donor specific antibodies [DSAs] and a…2017 American Transplant Congress
Impact of Antihypertensive (AHT) Choice and Advagraf® Dose on Immunologic Events in Renal Allografts 24 Months Post-Transplantation (Tx).
Renal allograft inflammation may be modulated by ACEi- or ARB-type AHTs (renin-angiotensin system (RAS)-targeting drugs that may inhibit calcineurin) or by optimizing tacrolimus (TAC) exposure.…2017 American Transplant Congress
Geographic Disparity in Kidney Transplantation After KAS.
1JHU, Baltimore; 2USNA, Annapolis; 3CDRG, Minneapolis
The Kidney Allocation System (KAS), implemented in 12/2014, increased regional and national sharing of kidneys. Ideally, broader sharing would also reduce some of the stark…2017 American Transplant Congress
Tracking the In Vitro Phenotype and Proliferative Capacity of CD57+ CD4 T Cells.
1Duke University, Durham; 2Bristol-Meyers Squibb, Princeton
CD57+PD1- CD4 T cells are primed effectors with increased expression of adhesion molecules capable of infiltrating allografts and mediating belatacept-resistant rejection (BRR). Whether CD57 is…2017 American Transplant Congress
Factors Predicting 30-Day Hospital Readmission After Kidney Transplant.
Rush University Medical Center, Chicago, IL
Background: Hospital readmissions after kidney transplant have been associated with increased morbidity, mortality, decreased quality of life, and increased healthcare costs. The objective of this…2017 American Transplant Congress
Saftey & Long Term Outcomes of Tocilizumab (Anti-IL6R, TCZ) Therapy in Treatment of Chronic Antibody Mediated Rejection (CABMR) & Transplant Glomerulopathy (TG) in Highly-HLA Sensitized (HS) Patients (PTs).
Introduction: DSAs in HS pts lead to poor allograft survival & return to a dialysis. Treatment options for CABMR and TG are limited. IL-6 appears…
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